Alcohol challenge with sons of alcoholics: a critical review and analysis.
paper
Cited
Public
Unavailable
- Authors
- Newlin, D B; Thomson, J B
- Year
- 1990
- Journal
- Psychological bulletin
- PMID
- 2270234
- DOI
- 10.1037/0033-2909.108.3.383
Studies are reviewed in which response to acute administration of alcohol was compared between individuals with and without family histories of alcoholism (FH+, FH-). This research represents a search for a psychobiological marker for alcoholism. A methodological critique of the procedures reported in this literature is then presented. Finally, a conceptual model is suggested in which differences in the response to alcohol between FH+ individuals and FH- individuals must be understood in relation to time after drinking alcohol. This Newtonian differentiator model proposes that sons of alcoholics exhibit acute sensitization as blood alcohol level rises and acute tolerance as blood alcohol level falls, compared with sons of nonalcoholics. Therefore, FH+ subjects find alcohol more rewarding because they accentuate the pleasurable, excitatory aspects of initial intoxication and attenuate the feelings of anxiety and depression that predominate as blood alcohol levels drop.
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| Across the spectrum: Acute alcohol responses in young adults with mild, moderate, and severe alcohol use disorder. | Thomas R et al. | β | 2025 | β |
| Alcohol and cannabis co-use: Probing subjective response in eliciting cross-substance craving. | McManus KR et al. | β | 2025 | β |
| A pilot study of impulsivity and subjective alcohol response in the lab and moment. | Stamates AL et al. | β | 2025 | β |
| Are you feeling what I'm feeling? Momentary interactions between personal and perceived peer subjective response predict craving and continued drinking in young adults. | King SE et al. | β | 2025 | β |
| Mapping acute alcohol effects on bodily sensations: A cross-dimensional interoceptive approach. | Leganes-Fonteneau M et al. | β | 2025 | β |
| The Dopamine System in Mediating Alcohol Effects in Humans. | Beck A et al. | β | 2025 | β |
| Alcohol consumption questionnaire: Scale development in a sample of Mexican American young adults and association with ADH7. | Ehlers CL et al. | β | 2024 | β |
| Genetic influences on alcohol sensitivity: A critical review. | Yeung EW et al. | β | 2024 | β |
| High-intensity sweet taste as a predictor of subjective alcohol responses to the ascending limb of an intravenous alcohol prime: an fMRI study. | Alessi J et al. | β | 2024 | β |
| Identification of Phosphodiesterase-7A (PDE7A) as a Novel Target for Reducing Ethanol Consumption in Mice. | Wei R et al. | β | 2024 | β |
| Retrospective self-reports of sensitivity to the effects of alcohol: Trait-like stability and concomitant changes with alcohol involvement. | Kohen CB et al. | β | 2024 | β |
| The PDE4 inhibitor apremilast modulates ethanol responses in Gabrb1-S409A knock-in mice via PKA-dependent and independent mechanisms. | Blednov YA et al. | β | 2024 | β |
| A preliminary investigation of salivary Ξ±-amylase as a novel biomarker of subjective response to alcohol: A brief report. | King SE et al. | β | 2023 | β |
| Cognitive preoccupation with drinking and behavioral effects of alcohol as predictors of current consumption patterns. | Allen HC et al. | β | 2023 | β |
| Drinking context, alcohol use, and subjective responses during binge drinking episodes measured by high-resolution ecological momentary assessment (HR-EMA). | Fischer AM et al. | β | 2023 | β |
| Heightened motor impairment as a protective factor against heavy drinking in individuals with high alcohol-induced disinhibition. | Allen HC et al. | β | 2023 | β |
| Self-report assessment of alcohol sensitivity: An examination of the effects of different probes. | Boness CL et al. | β | 2023 | β |
| Stimulant-like subjective effects of alcohol are not related to resting-state connectivity in healthy men. | Han J et al. | β | 2023 | β |
| Acute alcohol rewarding effects as a risk factor for hangover frequency. | Chavarria J et al. | β | 2022 | β |
| Binge and high-intensity drinking-Associations with intravenous alcohol self-administration and underlying risk factors. | Plawecki MH et al. | β | 2022 | β |
| Craving, stimulation, and sedation as predictors of alcohol demand under intoxication. | Motschman CA et al. | β | 2022 | β |
| Genome-wide association mapping of ethanol sensitivity in the Diversity Outbred mouse population. | Parker CC et al. | β | 2022 | β |
| Modeling Aversion Resistant Alcohol Intake in Indiana Alcohol-Preferring (P) Rats. | Katner SN et al. | β | 2022 | β |
| Moderators of subjective response to alcohol in the human laboratory. | Nieto SJ et al. | β | 2022 | β |
| Momentary subjective responses to alcohol as predictors of continuing to drink during daily-life drinking episodes. | Wycoff AM et al. | β | 2022 | β |
| The prospective interactive effects of alcohol expectancies and subjective response on future drinking behavior. | Waddell JT et al. | β | 2022 | β |
| Acute rewarding and disinhibiting effects of alcohol as indicators of drinking habits. | Allen HC et al. | β | 2021 | β |
| Common Factors Underlying Diverse Responses in Alcohol Use Disorder. | Chebolu E et al. | β | 2021 | β |
| Deletion of Tlr3 reduces acute tolerance to alcohol and alcohol consumption in the intermittent access procedure in male mice. | Blednov YA et al. | β | 2021 | β |
| Genome-wide association mapping of ethanol sensitivity in the Diversity Outbred mouse population | Parker CC et al. | β | 2021 | β |
| High Recreational Gamblers Show Increased Stimulatory Effects of an Acute Laboratory Gambling Challenge. | Miller L et al. | β | 2021 | β |
| Relationship between level of response to alcohol and acute tolerance. | Anthenelli RM et al. | β | 2021 | β |
| Subjective response to alcohol: Associated alcohol use and orbitofrontal gray matter volume in bipolar disorder. | Tretyak V et al. | β | 2021 | β |
| The Etiologic, Theory-Based, Ontogenetic Hierarchical Framework of Alcohol Use Disorder: A Translational Systematic Review of Reviews. | Boness CL et al. | β | 2021 | β |
| Translating preclinical models of alcohol seeking and consumption into the human laboratory using intravenous alcohol self-administration paradigms. | Cyders MA et al. | β | 2021 | β |
| Alcohol Sensitivity as an Endophenotype of Alcohol Use Disorder: Exploring Its Translational Utility between Rodents and Humans. | Parker CC et al. | β | 2020 | β |
| Alcohol sensitivity in women after undergoing bariatric surgery: a cross-sectional study. | Acevedo MB et al. | β | 2020 | β |
| Alcohol Tolerance in Human Laboratory Studies for Development of Medications to treat Alcohol Use Disorder. | Haass-Koffler CL et al. | β | 2020 | β |
| An Exploratory Factor Analysis of the Stimulant, Sedative, and Affective Responses to Alcohol. | Grodin EN et al. | β | 2020 | β |
| Context, acute tolerance, and subjective response affect alcohol-impaired driving decisions. | Motschman CA et al. | β | 2020 | β |
| Getting to the Heart of Low Sensitivity to Alcohol: Context Moderates Low Cardiovascular Response to Alcohol in Persons With a Family History of Alcohol Use Disorder. | Bates ME et al. | β | 2020 | β |
| Is craving a risk factor for substance use among treatment-seeking individuals with alcohol and other drugs use disorders? A meta-analytic review. | Cavicchioli M et al. | β | 2020 | β |
| Systems genetics analysis of the LXS recombinant inbred mouse strains:Genetic and molecular insights into acute ethanol tolerance. | Radcliffe RA et al. | β | 2020 | β |
| Translational dynamics of alcohol tolerance of preclinical models and human laboratory studies. | Haass-Koffler CL et al. | β | 2020 | β |
| Comparison of Subjective Responses to Oral and Intravenous Alcohol Administration Under Similar Systemic Exposures. | Plawecki MH et al. | β | 2019 | β |
| Complex interactions between the subject factors of biological sex and prior histories of binge-drinking and unpredictable stress influence behavioral sensitivity to alcohol and alcohol intake. | Quadir SG et al. | β | 2019 | β |
| Does Self-Reported or Behavioral Impulsivity Predict Subjective Response to Low-Dose Alcohol? | Berey BL et al. | β | 2019 | β |
| Evidence for incentive salience sensitization as a pathway to alcohol use disorder. | CofresΓ RU et al. | β | 2019 | β |
| Increased Alcohol-Drinking Induced by Manipulations of mGlu5 Phosphorylation within the Bed Nucleus of the Stria Terminalis. | Campbell RR et al. | β | 2019 | β |
| Interactive Effects of Naturalistic Drinking Context and Alcohol Sensitivity on Neural Alcohol Cue-Reactivity Responses. | Martins JS et al. | β | 2019 | β |
| Long-term exposure to daily ethanol injections in DBA/2J and Swiss mice: Lessons for the interpretation of ethanol sensitization. | Didone V et al. | β | 2019 | β |
| Mobile alcohol biosensors and pharmacotherapy development research. | Roberts W et al. | β | 2019 | β |
| Relationships between generalized impulsivity and subjective stimulant and sedative responses following alcohol administration. | Berey BL et al. | β | 2019 | β |
| The role of alcohol response phenotypes in the risk for alcohol use disorder. | King AC et al. | β | 2019 | β |
| Comparison of subjective response to alcohol in Caucasian and Hispanic/Latino samples. | Richner KA et al. | β | 2018 | β |
| Differences in the subjective and motivational properties of alcohol across alcohol use severity: application of a novel translational human laboratory paradigm. | Bujarski S et al. | β | 2018 | β |
| Interactions between TLR4 methylation and alcohol consumption on subjective responses to an alcohol infusion. | Karoly HC et al. | β | 2018 | β |
| Polymorphism study of nine SNPs associated with subjective response to alcohol in Chinese Han, Hui, Tibetan, Mongolian and Uygur populations. | Wei Q et al. | β | 2018 | β |
| Striatal activity correlates with stimulant-like effects of alcohol in healthy volunteers. | Weafer J et al. | β | 2018 | β |
| The Arf6 activator Efa6/PSD3 confers regional specificity and modulates ethanol consumption in Drosophila and humans. | Gonzalez DA et al. | β | 2018 | β |
| The Cerebellar GABA<sub>A</sub>R System as a Potential Target for Treating Alcohol Use Disorder. | Rossi DJ et al. | β | 2018 | β |
| A cis-eQTL in OPRM1 is Associated with Subjective Response to Alcohol and Alcohol Use. | Otto JM et al. | β | 2017 | β |
| A prospective study of genetic factors, human laboratory phenotypes, and heavy drinking in late adolescence. | Hendershot CS et al. | β | 2017 | β |
| Association of Anticipated and Laboratory-Derived Alcohol Stimulation, Sedation, and Reward. | Fridberg DJ et al. | β | 2017 | β |
| Craving and acute effects of alcohol in youths' daily lives: Associations with alcohol use disorder severity. | Treloar H et al. | β | 2017 | β |
| Does familial risk for alcohol use disorder predict alcohol hangover? | Stephens R et al. | β | 2017 | β |
| Effects of the serotonin transporter gene, sensitivity of response to alcohol, and parental monitoring on risk for problem alcohol use. | Cope LM et al. | β | 2017 | β |
| Functional significance of subjective response to alcohol across levels of alcohol exposure. | Bujarski S et al. | β | 2017 | β |
| Impulsivity Moderates Subjective Responses to Alcohol in Alcohol-Dependent Individuals. | Westman JG et al. | β | 2017 | β |
| Inhalation of Alcohol Vapor: Measurement and Implications. | MacLean RR et al. | β | 2017 | β |
| Longitudinal influence of alcohol and marijuana use on academic performance in college students. | Meda SA et al. | β | 2017 | β |
| Rat animal models for screening medications to treat alcohol use disorders. | Bell RL et al. | β | 2017 | β |
| Recreational concentrations of alcohol enhance synaptic inhibition of cerebellar unipolar brush cells via pre- and postsynaptic mechanisms. | Richardson BD et al. | β | 2017 | β |
| Relationships of Impulsivity and Subjective Response to Alcohol Use and Related Problems. | Berey BL et al. | β | 2017 | β |
| Subjective alcohol responses in a cross-sectional, field-based study of adolescents and young adults: Effects of age, drinking level, and dependence/consequences. | Treloar H et al. | β | 2017 | β |
| Test-retest reliability of the underlying latent factor structure of alcohol subjective response. | Lutz JA et al. | β | 2017 | β |
| Alcohol-Induced Stimulation Mediates the Effect of a GABRA2 SNP on Alcohol Self-Administrated among Alcohol-Dependent Individuals. | Boyd SJ et al. | β | 2016 | β |
| Effect of Alcohol on Encoding and Consolidation of Memory for Alcohol-Related Images. | Weafer J et al. | β | 2016 | β |
| Experimental psychopathology paradigms for alcohol use disorders: Applications for translational research. | Bujarski S et al. | β | 2016 | β |
| Genome characterization of the selected long- and short-sleep mouse lines. | Dowell R et al. | β | 2016 | β |
| Homer2 regulates alcohol and stress cross-sensitization. | Quadir SG et al. | β | 2016 | β |
| Identification of quantitative trait loci and candidate genes for an anxiolytic-like response to ethanol in BXD recombinant inbred strains. | Putman AH et al. | β | 2016 | β |
| Individual differences in subjective alcohol responses and alcohol-related disinhibition. | Quinn PD et al. | β | 2016 | β |
| Persisting Differences in the Sensitivity to the Effects of Alcohol: What We Know and Where to Go From Here. | Pedersen SL | β | 2016 | β |
| Subjective Response to Alcohol as a Research Domain Criterion. | Ray LA et al. | β | 2016 | β |
| The Alcohol Sensitivity Questionnaire: Evidence for Construct Validity. | Fleming KA et al. | β | 2016 | β |
| The natural expression of individual differences in self-reported level of response to alcohol during ecologically assessed drinking episodes. | Trela CJ et al. | β | 2016 | β |
| Adaptation of Subjective Responses to Alcohol is Affected by an Interaction of GABRA2 Genotype and Recent Drinking. | Kosobud AE et al. | β | 2015 | β |
| Alcohol-induced changes in conflict monitoring and error detection as predictors of alcohol use in late adolescence. | Korucuoglu O et al. | β | 2015 | β |
| A multilevel structural equation model of within- and between-person associations among subjective responses to alcohol, craving, and laboratory alcohol self-administration. | Wardell JD et al. | β | 2015 | β |
| An Assay for Measuring the Effects of Ethanol on the Locomotion Speed of Caenorhabditis elegans. | Davies AG et al. | β | 2015 | β |
| A novel cholinergic action of alcohol and the development of tolerance to that effect in Caenorhabditis elegans. | Hawkins EG et al. | β | 2015 | β |
| Application of an alcohol clamp paradigm to examine inhibitory control, subjective responses, and acute tolerance in late adolescence. | Hendershot CS et al. | β | 2015 | β |
| Attentional bias to alcohol-related stimuli as an indicator of changes in motivation to drink. | Roberts W et al. | β | 2015 | β |
| BK Channel Ξ²1 Subunit Contributes to Behavioral Adaptations Elicited by Chronic Intermittent Ethanol Exposure. | Kreifeldt M et al. | β | 2015 | β |
| Differences in subjective response to alcohol by gender, family history, heavy episodic drinking, and cigarette use: refining and broadening the scope of measurement. | Morean ME et al. | β | 2015 | β |
| Differences in subjective response to alcohol in heavy- and light-drinking Chinese men versus Caucasian American men. | Rueger SY et al. | β | 2015 | β |
| Endophenotypes for Alcohol Use Disorder: An Update on the Field. | Salvatore JE et al. | β | 2015 | β |
| Factor Structure of Subjective Responses to Alcohol in Light and Heavy Drinkers. | Bujarski S et al. | β | 2015 | β |
| S6 Kinase Reflects and Regulates Ethanol-Induced Sedation. | Acevedo SF et al. | β | 2015 | β |
| Subjective response as a consideration in the pharmacogenetics of alcoholism treatment. | Roche DJ et al. | β | 2015 | β |
| SWI/SNF chromatin remodeling regulates alcohol response behaviors in Caenorhabditis elegans and is associated with alcohol dependence in humans. | Mathies LD et al. | β | 2015 | β |
| Alcohol challenge responses predict future alcohol use disorder symptoms: a 6-year prospective study. | King AC et al. | β | 2014 | β |
| Are we drunk yet? Motor versus cognitive cues of subjective intoxication. | Celio MA et al. | β | 2014 | β |
| A social-attributional analysis of alcohol response. | Fairbairn CE et al. | β | 2014 | β |
| Attention-deficit/hyperactivity disorder and risk of substance use disorder: developmental considerations, potential pathways, and opportunities for research. | Molina BS et al. | β | 2014 | β |
| Differential striatal dopamine responses following oral alcohol in individuals at varying risk for dependence. | Setiawan E et al. | β | 2014 | β |
| Drinking consequences and subsequent drinking in college students over 4 years. | Martinez JA et al. | β | 2014 | β |
| Genetic influences on response to alcohol and response to pharmacotherapies for alcoholism. | Enoch MA | β | 2014 | β |
| Genetic relationship between predisposition for binge alcohol consumption and blunted sensitivity to adverse effects of alcohol in mice. | Fritz BM et al. | β | 2014 | β |
| High drinking in the dark mice: a genetic model of drinking to intoxication. | Barkley-Levenson AM et al. | β | 2014 | β |
| Influence of sensation seeking on response to alcohol versus placebo: implications for the acquired preparedness model. | Scott C et al. | β | 2014 | β |
| Paternal alcohol exposure reduces alcohol drinking and increases behavioral sensitivity to alcohol selectively in male offspring. | Finegersh A et al. | β | 2014 | β |
| Relationships between impulsivity and subjective response in an IV ethanol paradigm. | Leeman RF et al. | β | 2014 | β |
| Stimulant and motivational effects of alcohol: lessons from rodent and primate models. | Brabant C et al. | β | 2014 | β |
| Subjective response to alcohol and associated craving in heavy drinkers vs. alcohol dependents: an examination of Koob's allostatic model in humans. | Bujarski S et al. | β | 2014 | β |
| The answer you get depends on the question you ask. | Schuckit MA | β | 2014 | β |
| The effect of prior alcohol consumption on the ataxic response to alcohol in high-alcohol preferring mice. | Fritz BM et al. | β | 2014 | β |
| The omega-3 fatty acid eicosapentaenoic acid is required for normal alcohol response behaviors in C. elegans. | Raabe RC et al. | β | 2014 | β |
| Understanding alcohol use disorders with neuroelectrophysiology. | Rangaswamy M et al. | β | 2014 | β |
| Variation in AKR1C3, which encodes the neuroactive steroid synthetic enzyme 3Ξ±-HSD type 2 (17Ξ²-HSD type 5), moderates the subjective effects of alcohol. | Milivojevic V et al. | β | 2014 | β |
| Determining the heritability of ethanol-induced locomotor sensitization in mice using short-term behavioral selection. | Linsenbardt DN et al. | β | 2013 | β |
| Differences in acute response to alcohol between African Americans and European Americans. | Pedersen SL et al. | β | 2013 | β |
| Effects of family history of alcohol dependence on the subjective response to alcohol using the intravenous alcohol clamp. | Kerfoot K et al. | β | 2013 | β |
| GABRA2 markers moderate the subjective effects of alcohol. | Uhart M et al. | β | 2013 | β |
| Genetic studies of acute tolerance, rapid tolerance, and drinking in the dark in the LXS recombinant inbred strains. | Radcliffe RA et al. | β | 2013 | β |
| Inattention, impulsive action, and subjective response to D-amphetamine. | Weafer J et al. | β | 2013 | β |
| Modeling the diagnostic criteria for alcohol dependence with genetic animal models. | Crabbe JC et al. | β | 2013 | β |
| Psychophysiological responses to stress following alcohol intake in social drinkers who are at risk of hazardous drinking. | Nakajima M et al. | β | 2013 | β |
| Selection for high alcohol preference drinking in mice results in heightened sensitivity and rapid development of acute functional tolerance to alcohol's ataxic effects. | Fritz BM et al. | β | 2013 | β |
| Simultaneous use of non-medical ADHD prescription stimulants and alcohol among undergraduate students. | Egan KL et al. | β | 2013 | β |
| The amphetamine response moderates the relationship between negative emotionality and alcohol use. | Allen KJ et al. | β | 2013 | β |
| The developmental psychopathology of alcohol use and alcohol disorders: research achievements and future directions. | Chassin L et al. | β | 2013 | β |
| The dopamine system in mediating alcohol effects in humans. | Charlet K et al. | β | 2013 | β |
| The Subjective Effects of Alcohol Scale: development and psychometric evaluation of a novel assessment tool for measuring subjective response to alcohol. | Morean ME et al. | β | 2013 | β |
| Validation of the brief Biphasic Alcohol Effects Scale (B-BAES). | Rueger SY et al. | β | 2013 | β |
| Alcohol exposure rate control through physiologically based pharmacokinetic modeling. | Plawecki MH et al. | β | 2012 | β |
| Bridging Animal and Human Models: Translating From (and to) Animal Genetics. | Barkley-Levenson AM et al. | β | 2012 | β |
| Does family history of alcohol problems influence college and university drinking or substance use? A meta-analytical review. | Elliott JC et al. | β | 2012 | β |
| Do initial responses to drugs predict future use or abuse? | de Wit H et al. | β | 2012 | β |
| Ethanol sensitivity in high drinking in the dark selectively bred mice. | Crabbe JC et al. | β | 2012 | β |
| Ethanol tolerance and withdrawal severity in high drinking in the dark selectively bred mice. | Crabbe JC et al. | β | 2012 | β |
| Gene Expression Under the Influence: Transcriptional Profiling of Ethanol in the Brain. | Contet C | β | 2012 | β |
| Human laboratory paradigms in alcohol research. | Plebani JG et al. | β | 2012 | β |
| Intracranial self-stimulation in FAST and SLOW mice: effects of alcohol and cocaine. | Fish EW et al. | β | 2012 | β |
| Levels of explanation in psychiatric and substance use disorders: implications for the development of an etiologically based nosology. | Kendler KS | β | 2012 | β |
| Quantitative trait loci for sensitivity to ethanol intoxication in a C57BL/6JΓ129S1/SvImJ inbred mouse cross. | Chesler EJ et al. | β | 2012 | β |
| Reduced subjective response to acute ethanol administration among young men with a broad bipolar phenotype. | Yip SW et al. | β | 2012 | β |
| Subjective Effects of Thiopental in Young Adults with and without a Family History of Alcoholism. | Petrakis IL et al. | β | 2012 | β |
| Subjective perceptions associated with the ascending and descending slopes of breath alcohol exposure vary with recent drinking history. | Wetherill L et al. | β | 2012 | β |
| The negative effects of alcohol hangover on high-anxiety phenotype rats are influenced by the glutamate receptors of the dorsal midbrain. | Ezequiel Leite L et al. | β | 2012 | β |
| Translational behaviour-genetic studies of alcohol: are we there yet? | Crabbe JC | β | 2012 | β |
| A genetic determinant of the striatal dopamine response to alcohol in men. | Ramchandani VA et al. | β | 2011 | β |
| A Heuristic for Developing Transdiagnostic Models of Psychopathology: Explaining Multifinality and Divergent Trajectories. | Nolen-Hoeksema S et al. | β | 2011 | β |
| A novel role for PSD-95 in mediating ethanol intoxication, drinking and place preference. | Camp MC et al. | β | 2011 | β |
| arouser reveals a role for synapse number in the regulation of ethanol sensitivity. | Eddison M et al. | β | 2011 | β |
| Healthy subjects with a family history of alcoholism show increased stimulative subjective effects of alcohol. | SΓΆderpalm Gordh AH et al. | β | 2011 | β |
| Predictors and outcomes of variability in subjective alcohol intoxication among college students: an event-level analysis across 4 years. | Quinn PD et al. | β | 2011 | β |
| Response inhibition impairments predict alcohol-induced sedation. | Shannon EE et al. | β | 2011 | β |
| Rewarding, stimulant, and sedative alcohol responses and relationship to future binge drinking. | King AC et al. | β | 2011 | β |
| Role of GABRA2 in moderating subjective responses to alcohol. | Roh S et al. | β | 2011 | β |
| Stress and consumption of alcohol in humans with a Type 1 family history of alcoholism in an experimental laboratory setting. | Gordh AH et al. | β | 2011 | β |
| Subjective responses to alcohol: a paradigm shift may be brewing. | King AC et al. | β | 2011 | β |
| Subjective response to alcohol challenge: a quantitative review. | Quinn PD et al. | β | 2011 | β |
| The genetic relationships between ethanol preference, acute ethanol sensitivity, and ethanol tolerance in Drosophila melanogaster. | Devineni AV et al. | β | 2011 | β |
| Tolerance to ethanol's ataxic effects and alterations in ethanol-induced locomotion following repeated binge-like ethanol intake using the DID model. | Linsenbardt DN et al. | β | 2011 | β |
| Binge drinking effects on EEG in young adult humans. | Courtney KE et al. | β | 2010 | β |
| Electrophysiological evidence of alcohol-related attentional bias in social drinkers low in alcohol sensitivity. | Shin E et al. | β | 2010 | β |
| Genome-wide scan for self-rating of the effects of alcohol in American Indians. | Ehlers CL et al. | β | 2010 | β |
| Hangover and risk for alcohol use disorders: existing evidence and potential mechanisms. | Piasecki TM et al. | β | 2010 | β |
| High risk groups often have higher levels of alcohol response than low risk: the other side of the coin. | Newlin DB et al. | β | 2010 | β |
| Human and laboratory rodent low response to alcohol: is better consilience possible? | Crabbe JC et al. | β | 2010 | β |
| Initial evidence of an association between OPRM1 and adolescent alcohol misuse. | Miranda R et al. | β | 2010 | β |
| Neuronal nicotinic acetylcholine receptors as pharmacotherapeutic targets for the treatment of alcohol use disorders. | Chatterjee S et al. | β | 2010 | β |
| Reward sensitivity: issues of measurement, and achieving consilience between human and animal phenotypes. | Stephens DN et al. | β | 2010 | β |
| Sensitivity to ethanol and other hedonic stimuli in an animal model of adolescence: implications for prevention science? | Spear LP et al. | β | 2010 | β |
| Subjective responses to alcohol consumption as endophenotypes: advancing behavioral genetics in etiological and treatment models of alcoholism. | Ray LA et al. | β | 2010 | β |
| Subjective response to alcohol: a critical review of the literature. | Morean ME et al. | β | 2010 | β |
| The comprehensive alcohol expectancy questionnaire: confirmatory factor analysis, scale refinement, and further validation. | Nicolai J et al. | β | 2010 | β |
| A major QTL for acute ethanol sensitivity in the alcohol tolerant and non-tolerant selected rat lines. | Radcliffe RA et al. | β | 2009 | β |
| An examination of subjective response to alcohol in African Americans. | Pedersen SL et al. | β | 2009 | β |
| Binge drinking in young adults: Data, definitions, and determinants. | Courtney KE et al. | β | 2009 | β |
| Catching the alcohol buzz: an examination of the latent factor structure of subjective intoxication. | Ray LA et al. | β | 2009 | β |
| Combined scopolamine and ethanol treatment results in a locomotor stimulant response suggestive of synergism that is not blocked by dopamine receptor antagonists. | Scibelli AC et al. | β | 2009 | β |
| Effects of alcohol and blood alcohol concentration limb on sexual risk-taking intentions. | Davis KC et al. | β | 2009 | β |
| Effects of topiramate and other anti-glutamatergic drugs on the acute intoxicating actions of ethanol in mice: modulation by genetic strain and stress. | Chen YC et al. | β | 2009 | β |
| Ethanol administration dampens the prolactin response to psychosocial stress exposure in sons of alcohol-dependent fathers. | Zimmermann US et al. | β | 2009 | β |
| Expanding the utility of the Biphasic Alcohol Effects Scale (BAES) and initial psychometric support for the Brief-BAES (B-BAES). | Rueger SY et al. | β | 2009 | β |
| Offspring of parents with an alcohol use disorder prefer higher levels of brain alcohol exposure in experiments involving computer-assisted self-infusion of ethanol (CASE). | Zimmermann US et al. | β | 2009 | β |
| Subjective responses to alcohol prime event-specific alcohol consumption and predict blackouts and hangover. | Wetherill RR et al. | β | 2009 | β |
| Subjective stimulant and sedative effects of alcohol during early drinking experiences predict alcohol involvement in treated adolescents. | Chung T et al. | β | 2009 | β |
| Young Investigator Award symposium. | Witkiewitz K et al. | β | 2009 | β |
| Anticipating problem alcohol use developmentally from childhood into middle adulthood: what have we learned? | Zucker RA | β | 2008 | β |
| Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians. | Ehlers CL et al. | β | 2008 | β |
| Blunted psychotomimetic and amnestic effects of delta-9-tetrahydrocannabinol in frequent users of cannabis. | D'Souza DC et al. | β | 2008 | β |
| Effects of chronic swim stress on EtOH-related behaviors in C57BL/6J, DBA/2J and BALB/cByJ mice. | Boyce-Rustay JM et al. | β | 2008 | β |
| Genomic insights into acute alcohol tolerance. | Hu W et al. | β | 2008 | β |
| Later that night: descending alcohol intoxication and men's sexual arousal. | George WH et al. | β | 2008 | β |
| Overview of mouse assays of ethanol intoxication. | Crabbe JC et al. | β | 2008 | β |
| Relationship between ethanol's acute locomotor effects and ethanol self-administration in male Long-Evans rats. | Chappell AM et al. | β | 2008 | β |
| Stimulant alcohol effects prime within session drinking behavior. | Corbin WR et al. | β | 2008 | β |
| Subjective alcohol effects and drinking behavior: the relative influence of early response and acquired tolerance. | Morean ME et al. | β | 2008 | β |
| Acute functional tolerance to ethanol mediated by protein kinase Cepsilon. | Wallace MJ et al. | β | 2007 | β |
| An investigation of the behavioral actions of ethanol across adolescence in mice. | Hefner K et al. | β | 2007 | β |
| Automatic and controlled processes and the development of addictive behaviors in adolescents: a review and a model. | Wiers RW et al. | β | 2007 | β |
| Chronic swim stress alters sensitivity to acute behavioral effects of ethanol in mice. | Boyce-Rustay JM et al. | β | 2007 | β |
| Effect of mu-opioid receptor gene polymorphisms on heroin-induced subjective responses in a Chinese population. | Zhang D et al. | β | 2007 | β |
| How gene-stress-behavior interactions can promote adolescent alcohol use: the roles of predrinking allostatic load and childhood behavior disorders. | Zimmermann US et al. | β | 2007 | β |
| Relationship between the cardiac response to acute intoxication and alcohol-induced subjective effects throughout the blood alcohol concentration curve. | Brunelle C et al. | β | 2007 | β |
| Short-term selection for acute ethanol tolerance and sensitization from an F2 population derived from the high and low alcohol-sensitive selectively bred rat lines. | Radcliffe RA et al. | β | 2007 | β |
| The biphasic effects of alcohol: comparisons of subjective and objective measures of stimulation, sedation, and physical activity. | Addicott MA et al. | β | 2007 | β |
| Candidate genes and their regulatory elements: alcohol preference and tolerance. | Saba L et al. | β | 2006 | β |
| Confirmation of quantitative trait loci for ethanol sensitivity and neurotensin receptor density in crosses derived from the inbred high and low alcohol sensitive selectively bred rat lines. | Radcliffe RA et al. | β | 2006 | β |
| Enhanced sensitivity to the euphoric effects of alcohol in schizophrenia. | D'Souza DC et al. | β | 2006 | β |
| Gelatin "shots" as a new method for alcohol administration in a laboratory setting. | Ralevski E et al. | β | 2006 | β |
| Heart rate response to alcohol and intoxicated aggressive behavior. | Assaad JM et al. | β | 2006 | β |
| Patterns of simultaneous polysubstance use in drug using university students. | Barrett SP et al. | β | 2006 | β |
| Preliminary data on the association among the serotonin transporter polymorphism, subjective alcohol experiences, and drinking behavior. | Corbin WR et al. | β | 2006 | β |
| Psychiatric morbidity and parental substance use disorder. | Westermeyer J et al. | β | 2006 | β |
| Rapid ethanol tolerance mediated by adaptations in acute tolerance in inbred mouse strains. | Radcliffe RA et al. | β | 2006 | β |
| Tolerance and withdrawal in goldfish exposed to ethanol. | Crawshaw LI et al. | β | 2006 | β |
| Tonic and phasic processes in the acute effects of alcohol. | Martin CS et al. | β | 2006 | β |
| Family history of alcoholism and response to amphetamine: sex differences in the effect of risk. | Gabbay FH | β | 2005 | β |
| GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride. | Pierucci-Lagha A et al. | β | 2005 | β |
| Genetic dissociation between ethanol sensitivity and rapid tolerance in mouse and rat strains selectively bred for differential ethanol sensitivity. | Radcliffe RA et al. | β | 2005 | β |
| Hangover frequency and risk for alcohol use disorders: evidence from a longitudinal high-risk study. | Piasecki TM et al. | β | 2005 | β |
| Individual differences in initial sensitivity and acute tolerance predict patterns of chronic drug tolerance to nitrous-oxide-induced hypothermia in rats. | Ramsay DS et al. | β | 2005 | β |
| Introduction to the special issue on ''relations between gambling and alcohol use''. | Stewart SH et al. | β | 2005 | β |
| Regulation of drug taking by sensitization and habituation. | McSweeney FK et al. | β | 2005 | β |
| Scheduled access to ethanol results in motor impairment and tolerance in female C57BL/6J mice. | Cronise K et al. | β | 2005 | β |
| The utility of neurophysiological markers in the study of alcoholism. | Porjesz B et al. | β | 2005 | β |
| Adenosine A1 receptors modulate the anxiolytic-like effect of ethanol in the elevated plus-maze in mice. | Prediger RD et al. | β | 2004 | β |
| Anxiety as a predictor of alcohol preference in rats? | Langen B et al. | β | 2004 | β |
| Arginine vasopressin and adrenocorticotropin secretion in response to psychosocial stress is attenuated by ethanol in sons of alcohol-dependent fathers. | Zimmermann U et al. | β | 2004 | β |
| Biological and behavioral markers of alcohol sensitivity. | Fromme K et al. | β | 2004 | β |
| Differential response to alcohol in light and moderate female social drinkers. | Evans SM et al. | β | 2004 | β |
| Effect of ethanol on hypothalamic-pituitary-adrenal system response to psychosocial stress in sons of alcohol-dependent fathers. | Zimmermann U et al. | β | 2004 | β |
| Motor impairing effects of ethanol and diazepam in rats selectively bred for high and low ethanol consumption in a limited-access paradigm. | Shram MJ et al. | β | 2004 | β |
| Pharmacogenetic insights to monoaminergic dysfunction in alcohol dependence. | Heinz A et al. | β | 2004 | β |
| Aggressiveness, family history of alcoholism, and the heart rate response to alcohol intoxication. | Assaad JM et al. | β | 2003 | β |
| Alcohol affects executive cognitive functioning differentially on the ascending versus descending limb of the blood alcohol concentration curve. | Pihl RO et al. | β | 2003 | β |
| Behavioral undercontrol and subjective stimulant and sedative effects of alcohol intoxication: independent predictors of drinking habits? | Erblich J et al. | β | 2003 | β |
| Biphasic stimulant and sedative effects of ethanol: are children of alcoholics really different? | Erblich J et al. | β | 2003 | β |
| Bivalent effects of MK-801 on ethanol-induced sensitization do not parallel its effects on ethanol-induced tolerance. | Meyer PJ et al. | β | 2003 | β |
| Hypothalamic-pituitary-adrenal system adaptation to detoxification in alcohol-dependent patients is affected by family history of alcoholism. | Zimmermann U et al. | β | 2003 | β |
| NMDA receptors in alcoholism. | Hoffman PL | β | 2003 | β |
| Regional CNS densities of serotonin 1A and dopamine D2 receptors in periadolescent alcohol-preferring P and alcohol-nonpreferring NP rat pups. | Strother WN et al. | β | 2003 | β |
| Response to alcohol in females with a paternal history of alcoholism. | Evans SM et al. | β | 2003 | β |
| Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors. | Tabakoff B et al. | β | 2003 | β |
| Acute effect of ethanol on anxiety and 5-HT in the prefrontal cortex of rats. | Langen B et al. | β | 2002 | β |
| Biphasic alcohol response differs in heavy versus light drinkers. | King AC et al. | β | 2002 | β |
| Implicit and explicit alcohol-related cognitions. | Wiers RW et al. | β | 2002 | β |
| Mecamylamine modifies the pharmacokinetics and reinforcing effects of alcohol. | Blomqvist O et al. | β | 2002 | β |
| Self-reported subjective perception of intoxication reflects family history of alcoholism when breath alcohol levels are constant. | Morzorati SL et al. | β | 2002 | β |
| The effects of alprazolam and buspirone in light and moderate female social drinkers. | Evans SM et al. | β | 2002 | β |
| The self-perceived survival ability and reproductive fitness (SPFit) theory of substance use disorders. | Newlin DB | β | 2002 | β |
| Association of the ADH2*3 allele with a negative family history of alcoholism in African American young adults. | Ehlers CL et al. | β | 2001 | β |
| Evidence that the Lore-1 region specifies ethanol-induced activation in addition to sedative/hypnotic sensitivity to ethanol. | Owens JC et al. | β | 2001 | β |
| Experimental mood inductions in persons at high and low risk for alcohol problems. | Randall DM et al. | β | 2001 | β |
| Finding paradigms for the future of alcoholism research: an interdisciplinary perspective. | Meyer RE | β | 2001 | β |
| Mismatch negativity in subjects at high risk for alcoholism. | Zhang XL et al. | β | 2001 | β |
| Parental alcoholism and the effects of alcohol on mediated semantic priming. | Sayette MA et al. | β | 2001 | β |
| Responsivity and development of tolerance to the motor impairing effects of moderate doses of ethanol in alcohol-preferring (P) and -nonpreferring (NP) rat lines. | Bell RL et al. | β | 2001 | β |
| Serotonergic dysfunction, negative mood states, and response to alcohol. | Heinz A et al. | β | 2001 | β |
| Visual p3 in female alcoholics. | Prabhu VR et al. | β | 2001 | β |
| Biological phenotypes associated with individuals at high risk for developing alcohol-related disorders. Part 2. | Schuckit MA | β | 2000 | β |
| Developmental sources of variation in liability to adolescent substance use disorders. | Dawes MA et al. | β | 2000 | β |
| Does the increase in locomotion induced by ethanol indicate its stimulant or anxiolytic properties? | Boerngen-Lacerda R et al. | β | 2000 | β |
| Genetics of the risk for alcoholism. | Schuckit MA | β | 2000 | β |
| Role of the GABA(A)beta2, GABA(A)alpha6, GABA(A)alpha1 and GABA(A)gamma2 receptor subunit genes cluster in drug responses and the development of alcohol dependence. | Loh EW et al. | β | 2000 | β |
| Smoking and the genetic contribution to alcohol-dependence risk. | Madden PA et al. | β | 2000 | β |
| Subjective and objective responses to ethanol in moderate/heavy and light social drinkers. | Holdstock L et al. | β | 2000 | β |
| The adolescent brain and age-related behavioral manifestations. | Spear LP | β | 2000 | β |
| Approaching avoidance. A step essential to the understanding of craving. | Breiner MJ et al. | β | 1999 | β |
| A preliminary study of acute responses to clamped alcohol concentration and family history of alcoholism. | Ramchandani VA et al. | β | 1999 | β |
| Children of alcoholics exhibit attenuated cognitive impairment during an ethanol challenge. | Erblich J et al. | β | 1999 | β |
| Electroencephalographic responses to alcohol challenge in Native American Mission Indians. | Ehlers CL et al. | β | 1999 | β |
| Event-related potentials elicited by a visual continuous performance task in children of alcoholics. | RodrΓguez HolguΓn S et al. | β | 1999 | β |
| Selective genotyping for the role of 5-HT2A, 5-HT2C, and GABA alpha 6 receptors and the serotonin transporter in the level of response to alcohol: a pilot study. | Schuckit MA et al. | β | 1999 | β |
| What is inherited in the predisposition toward alcoholism? A proposed model. | Begleiter H et al. | β | 1999 | β |
| Do young children of alcoholics hold more positive or negative alcohol-related expectancies than controls? | Wiers RW et al. | β | 1998 | β |
| Effects of ethanol on temporal recovery of auditory-evoked potentials in individuals at risk for alcoholism. | Cohen HL et al. | β | 1998 | β |
| Effects of moderate alcohol consumption on the central nervous system. | Eckardt MJ et al. | β | 1998 | β |
| Functional magnetic resonance imaging of alprazolam-induced changes in humans with familial alcoholism. | Streeter CC et al. | β | 1998 | β |
| Is a mild deficit in executive functions in boys related to childhood ADHD or to parental multigenerational alcoholism? | Wiers RW et al. | β | 1998 | β |
| Biphasic effects of alcohol on heart rate are influenced by alcoholic family history and rate of alcohol ingestion. | Conrod PJ et al. | β | 1997 | β |
| Event-related potentials in COA's. | Porjesz B et al. | β | 1997 | β |
| Prepulse inhibition of the startle reflex: preliminary study of the effects of a low dose of alcohol in humans. | Hutchison KE et al. | β | 1997 | β |
| Ethanol-induced change in cardiac and endogenous opiate function and risk for alcoholism. | Peterson JB et al. | β | 1996 | β |
| Initiation of ethanol self-administration by the sucrose-substitution method with HAS and LAS rats. | Files FJ et al. | β | 1996 | β |
| Alcoholism: the role of different motivational systems. | Pihl RO et al. | β | 1995 | β |
| Alcohol sensitivity and smoking history in men and women. | Madden PA et al. | β | 1995 | β |
| Is alcohol-related flushing a protective factor for alcoholism in Caucasians? | Slutske WS et al. | β | 1995 | β |
| Task persistence after alcohol consumption among children of alcoholics. | Baer JS et al. | β | 1995 | β |
| Variability of ethanol absorption and breath concentrations during a large-scale alcohol administration study. | Friel PN et al. | β | 1995 | β |
| Adrenocorticotropin responses following administration of ethanol and ovine corticotropin-releasing hormone in the sons of alcoholics and control subjects. | Waltman C et al. | β | 1994 | β |
| Anticipated biphasic effects of alcohol vary with risk for alcoholism: a preliminary report. | Earleywine M | β | 1994 | β |
| Confirming the factor structure of the anticipated biphasic alcohol effects scale. | Earleywine M | β | 1994 | β |
| Differential expression of guanosine triphosphate binding proteins in men at high and low risk for the future development of alcoholism. | Wand GS et al. | β | 1994 | β |
| Eye movement effects of diazepam in sons of alcoholic fathers and male control subjects. | Cowley DS et al. | β | 1994 | β |
| Personality risk for alcoholism and alcohol expectancies. | Earleywine M | β | 1994 | β |
| What for, alcohol research? | Meyer RE | β | 1994 | β |
| Acute and chronic alcohol tolerance in humans: effects of dose and consecutive days of exposure. | Bennett RH et al. | β | 1993 | β |
| Anticipated stimulant and sedative effects of alcohol vary with dosage and limb of the blood alcohol curve. | Earleywine M et al. | β | 1993 | β |
| Heart-rate reactivity and alcohol consumption among sons of male alcoholics and sons of non-alcoholics. | Peterson JB et al. | β | 1993 | β |
| Postural sway in children from pedigrees exhibiting a high density of alcoholism. | Hill SY et al. | β | 1993 | β |
| The effects of ethanol on EEG activity in males at risk for alcoholism. | Cohen HL et al. | β | 1993 | β |
| Meta-analysis of subjective sensitivity to alcohol in sons of alcoholics. | Pollock VE | β | 1992 | β |
| Response to diazepam in sons of alcoholics. | Cowley DS et al. | β | 1992 | β |
| Chronic tolerance and sensitization to alcohol in sons of alcoholics. | Newlin DB et al. | β | 1991 | β |
| Diazepam preference in males with and without an alcoholic first-degree relative. | de Wit H | β | 1991 | β |
| Nonassociative mechanisms in preferences for alcoholic flavors: differences between sons of alcoholics and sons of nonalcoholics. | Newlin DB et al. | β | 1991 | β |