Event-related potentials in COA's.
- Authors
- Porjesz, B; Begleiter, H
- Year
- 1997
- Journal
- Alcohol health and research world
- PMID
- 15706775
- PMCID
- PMC6826815
Evidence suggests that people at risk for developing alcoholism can be distinguished from those not at risk by measuring the electrical activity of the brain. Event-related potentials (ERP's) are brain electrical signals produced in response to specific sensory stimuli. Reduced voltage of an ERP called P300, or P3, appears to characterize offspring of alcoholic families, regardless of whether the offspring are themselves alcoholic. Reduced P3 may indicate susceptibility to alcoholism and may elucidate mechanisms of alcohol's effects on the nervous system.
Average event-related potential (ERP) responses (i.e., electrical responses to sensory stimulation of the brain) of male (left) and female (right) offspring of male alcoholics (i.e., high-risk subjects) compared with ERP responses of male and female offspring of nonalcoholics (i.e., low-risk subjects). Electrodes placed against the scalp record ERP’s from specific locations at the front (FZ), center (CZ), and rear (PZ) of the head. The height of the peak, or the amplitude, is measured in terms of the strength of the electrical signal (i.e., microvolts). The P300 component, which is the large positive peak occurring between 300–500 milliseconds after the stimulus, is reduced in voltage in both the male and female offspring of male alcoholics.
No entities extracted from this document yet.
No uploaded files.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Association of lifetime major depressive disorder with enhanced attentional sensitivity measured with P3 response in young adult twins. | Koskinen SM et al. | — | 2022 | → |
| Advances in Electrophysiological Research. | Kamarajan C et al. | — | 2015 | → |
| Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task. | Kamarajan C et al. | — | 2015 | → |
| A longitudinal twin study of effects of adolescent alcohol abuse on the neurophysiology of attention and orienting. | Koskinen SM et al. | — | 2011 | → |
| Dysfunctional reward processing in male alcoholics: an ERP study during a gambling task. | Kamarajan C et al. | — | 2010 | → |
| A functional MRI study of visual oddball: evidence for frontoparietal dysfunction in subjects at risk for alcoholism. | Rangaswamy M et al. | — | 2004 | → |
| Theta power in the EEG of alcoholics. | Rangaswamy M et al. | — | 2003 | → |
| What is inherited in the predisposition toward alcoholism? A proposed model. | Begleiter H et al. | — | 1999 | → |