Reduced P300 amplitude in relation to family history of alcoholism and antisocial personality disorder among young men at risk for alcoholism.
- Authors
- Hesselbrock, V; Bauer, L; O'Connor, S; Gillen, R
- Year
- 1993
- Journal
- Alcohol and alcoholism (Oxford, Oxfordshire). Supplement
- PMID
- 7748355
Both a family history of alcoholism (FH+) and a personal history of Antisocial Personality Disorder (ASP) increase the risk for developing alcoholism, particularly among males. Previous studies suggest that a reduced P300 event-related potential (ERP) amplitude is a marker of the presence of a family history of alcoholism. The present study examined the effects of both a FH+ and a personal history of ASP in relation to the P300 amplitude in a sample of 79 nonalcoholic young men. Reduced P300 ERP amplitudes elicited by a visual oddball task were found at the frontal electrode sites for both the FH+ and ASP groups, but not their interaction. There were no group differences in P300 latencies. P300 amplitude at Pz was associated with behavioral measures of figural memory, while P300 at F8 was associated with behavioral measures of cognitive flexibility.
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Variants of the P3 event-related potential operate as indicators of distinct mechanisms contributing to problematic alcohol use. | Joyner KJ et al. | — | 2024 | → |
| Cognitive Control Deficits in Alcohol Dependence Are a Trait- and State-Dependent Biomarker: An ERP Study. | Liu X et al. | — | 2020 | → |
| Heritability and molecular-genetic basis of the P3 event-related brain potential: a genome-wide association study. | Malone SM et al. | — | 2014 | → |
| Neural circuitry associated with risk for alcohol use disorders. | Tessner KD et al. | — | 2010 | → |
| Electrophysiological evidence for cortical abnormalities in obsessive-compulsive disorder - a replication study using auditory event-related P300 subcomponents. | Gohle D et al. | — | 2008 | → |
| Genes mediate the association between P3 amplitude and externalizing disorders. | Hicks BM et al. | — | 2007 | → |
| Auditory and visual P300 evoked potentials do not predict response to valproate treatment of aggression in patients with borderline and antisocial personality disorders. | Reeves RR et al. | — | 2005 | → |
| Spatial-anatomical mapping of NoGo-P3 in the offspring of alcoholics: evidence of cognitive and neural disinhibition as a risk for alcoholism. | Kamarajan C et al. | — | 2005 | → |
| The utility of neurophysiological markers in the study of alcoholism. | Porjesz B et al. | — | 2005 | → |
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