Alcohol challenges in young men from alcoholic pedigrees and control families: a report from the COGA project.
paper
Primary
Public
Unavailable
- Authors
- Schuckit, M A; Tsuang, J W; Anthenelli, R M; Tipp, J E; Nurnberger, J I
- Year
- 1996
- Journal
- Journal of studies on alcohol
- PMID
- 8776678
- DOI
- 10.15288/jsa.1996.57.368
OBJECTIVE: Alcoholism is a complex disorder that demonstrates genetic heterogeneity. Genetic linkage studies of alcohol dependence also suffer from the probability that many individuals who inherit an enhanced risk never develop the clinical syndrome. Thus, studies of genetic influences in alcohol abuse or dependence would benefit from the identification of characteristics of an individual that are associated with the probability of developing the disorder. A reduced responsivity to alcohol has been reported to characterize almost 40% of sons of alcoholics and to predict future alcohol abuse or dependence a decade later. This study explores the existence of this characteristic in a more heterogeneous sample that is part of a genetic pedigree study of families of alcoholics. METHOD: Eighteen to 30 year old subjects who were sons of alcohol dependent fathers and who were drinkers but not alcohol dependent were selected from pedigrees of alcoholics at all six sites of the Collaborative Study on the Genetics of Alcoholism (COGA) study. Family history negative controls matched on demography and substance use histories were selected for each subject. Data were obtained on 20 pairs of high-risk and low-risk men (40 subjects) following a challenge with 0.72 g/kg (0.9 ml/kg) of ethanol. Evaluations included measures of subjective feelings of intoxication and body sway, and changes in cortisol, ACTH and prolactin. RESULTS: The data corroborate a lower level of intensity of response to alcohol in the sons of alcoholics especially as measured by changes in cortisol, with similar but less robust changes in subjective feelings and other measures. CONCLUSIONS: The results expand upon earlier studies by using a more heterogeneous population of men at high alcoholism risk. The data highlight the possible usefulness of the reduced response to alcohol as an adjunct to future linkage analyses.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Reliable variability in subjective responses to parenteral hydromorphone administration: empirical confirmation of an opioid non-responder phenotype. | Ellis JD et al. | β | 2026 | β |
| Genetic influences on alcohol sensitivity: A critical review. | Yeung EW et al. | β | 2024 | β |
| Self-report assessment of alcohol sensitivity: An examination of the effects of different probes. | Boness CL et al. | β | 2023 | β |
| Subjective response to alcohol: Interactive effects of early life stress, parental risk for mood and substance use disorders, and drinking context. | Kosted R et al. | β | 2023 | β |
| Paternal alcohol exposure reduces acquisition of operant alcohol self-administration and affects Bdnf DNA methylation in male and female offspring. | Nieto SJ et al. | β | 2022 | β |
| Comparison of Subjective Responses to Oral and Intravenous Alcohol Administration Under Similar Systemic Exposures. | Plawecki MH et al. | β | 2019 | β |
| Convergent Evidence From Humans and Drosophila melanogaster Implicates the Transcription Factor MEF2B/Mef2 in Alcohol Sensitivity. | Schmitt RE et al. | β | 2019 | β |
| Drug-induced stress responses and addiction risk and relapse. | Wemm SE et al. | β | 2019 | β |
| Genetics of alcohol use disorder: a review. | Deak JD et al. | β | 2019 | β |
| Ethanol Regulates Presynaptic Activity and Sedation through Presynaptic Unc13 Proteins in <i>Drosophila</i>. | Xu S et al. | β | 2018 | β |
| Meta-Analysis of Genetic Influences on Initial Alcohol Sensitivity. | Edwards AC et al. | β | 2018 | β |
| The Cerebellar GABA<sub>A</sub>R System as a Potential Target for Treating Alcohol Use Disorder. | Rossi DJ et al. | β | 2018 | β |
| Alcohol, stress, and glucocorticoids: From risk to dependence and relapse in alcohol use disorders. | Blaine SK et al. | β | 2017 | β |
| Recreational concentrations of alcohol enhance synaptic inhibition of cerebellar unipolar brush cells via pre- and postsynaptic mechanisms. | Richardson BD et al. | β | 2017 | β |
| Limitations of lifetime alcohol use disorder assessments: A criterion-validation study. | Haeny AM et al. | β | 2016 | β |
| Ethanol-Induced Cerebellar Ataxia: Cellular and Molecular Mechanisms. | Dar MS | β | 2015 | β |
| Hypothalamic-pituitary-adrenal axis and behavioral dysfunction following early binge-like prenatal alcohol exposure in mice. | Wieczorek L et al. | β | 2015 | β |
| Effects of Ξ9-tetrahydrocannabinol in individuals with a familial vulnerability to alcoholism. | Ranganathan M et al. | β | 2014 | β |
| Externalizing disorders in adolescence mediate the effects of maternal depression on substance use disorders. | Tartter M et al. | β | 2014 | β |
| False negatives in the assessment of lifetime alcohol use disorders: a serious but unappreciated problem. | Haeny AM et al. | β | 2014 | β |
| Gender, history of alcohol use and number of drinks consumed predict craving among drinkers in a field setting. | Day AM et al. | β | 2014 | β |
| Genetic influences on response to alcohol and response to pharmacotherapies for alcoholism. | Enoch MA | β | 2014 | β |
| Initial subjective reward: single-exposure conditioned place preference to alcohol in mice. | Grisel JE et al. | β | 2014 | β |
| Association between Alcoholism Family History and Alcohol Screening Scores among Alcohol-dependent Patients. | Lee SH et al. | β | 2013 | β |
| Consensus paper of the WFSBP task force on biological markers: biological markers for alcoholism. | Hashimoto E et al. | β | 2013 | β |
| Opposite actions of alcohol on tonic GABA(A) receptor currents mediated by nNOS and PKC activity. | Kaplan JS et al. | β | 2013 | β |
| Primate cerebellar granule cells exhibit a tonic GABAAR conductance that is not affected by alcohol: a possible cellular substrate of the low level of response phenotype. | Mohr C et al. | β | 2013 | β |
| Recreational gamblers with and without parental addiction. | Schreiber LR et al. | β | 2012 | β |
| Glypican Gene GPC5 Participates in the Behavioral Response to Ethanol: Evidence from Humans, Mice, and Fruit Flies. | Joslyn G et al. | β | 2011 | β |
| Role of GABRA2 in moderating subjective responses to alcohol. | Roh S et al. | β | 2011 | β |
| Self-Rating of the Effects of Alcohol (SRE): Predictive utility and reliability across interview and self-report administrations. | Ray LA et al. | β | 2011 | β |
| Addictions and their familiality in Iceland. | Tyrfingsson T et al. | β | 2010 | β |
| Alcohol and aldehyde dehydrogenase polymorphisms in Chinese and Indian populations. | Tan EC et al. | β | 2010 | β |
| Aversive effects of ethanol in adolescent versus adult rats: potential causes and implication for future drinking. | Schramm-Sapyta NL et al. | β | 2010 | β |
| Genome-wide scan for self-rating of the effects of alcohol in American Indians. | Ehlers CL et al. | β | 2010 | β |
| Human and laboratory rodent low response to alcohol: is better consilience possible? | Crabbe JC et al. | β | 2010 | β |
| Human variation in alcohol response is influenced by variation in neuronal signaling genes. | Joslyn G et al. | β | 2010 | β |
| Neural circuitry associated with risk for alcohol use disorders. | Tessner KD et al. | β | 2010 | β |
| Subjective responses to alcohol consumption as endophenotypes: advancing behavioral genetics in etiological and treatment models of alcoholism. | Ray LA et al. | β | 2010 | β |
| Subjective response to alcohol: a critical review of the literature. | Morean ME et al. | β | 2010 | β |
| Subjective effects to cannabis are associated with use, abuse and dependence after adjusting for genetic and environmental influences. | Scherrer JF et al. | β | 2009 | β |
| Subjective responses to alcohol prime event-specific alcohol consumption and predict blackouts and hangover. | Wetherill RR et al. | β | 2009 | β |
| The overlap in predicting alcohol outcome for two measures of the level of response to alcohol. | Schuckit MA et al. | β | 2009 | β |
| Blunted psychotomimetic and amnestic effects of delta-9-tetrahydrocannabinol in frequent users of cannabis. | D'Souza DC et al. | β | 2008 | β |
| Chromosome 15q25.1 genetic markers associated with level of response to alcohol in humans. | Joslyn G et al. | β | 2008 | β |
| Ethnic differences in level of response to alcohol between Chinese Americans and Korean Americans. | Duranceaux NC et al. | β | 2008 | β |
| Mediators and moderators of parental alcoholism effects on offspring self-esteem. | Rangarajan S | β | 2008 | β |
| Impulsivity and chronic stress are associated with amphetamine-induced striatal dopamine release. | Oswald LM et al. | β | 2007 | β |
| Neurexin 3 polymorphisms are associated with alcohol dependence and altered expression of specific isoforms. | Hishimoto A et al. | β | 2007 | β |
| Rates of ethanol metabolism decrease in sons of alcoholics following a priming dose of ethanol. | Bradford BU et al. | β | 2007 | β |
| Attenuated cortisol response to alcohol in heavy social drinkers. | King A et al. | β | 2006 | β |
| Enhanced sensitivity to the euphoric effects of alcohol in schizophrenia. | D'Souza DC et al. | β | 2006 | β |
| Linkage disequilibrium, haplotype and association studies of a chromosome 4 GABA receptor gene cluster: candidate gene variants for addictions. | Drgon T et al. | β | 2006 | β |
| Preliminary data on the association among the serotonin transporter polymorphism, subjective alcohol experiences, and drinking behavior. | Corbin WR et al. | β | 2006 | β |
| A cross-generational comparison of alcohol challenges at about age 20 in 40 father-offspring pairs. | Schuckit MA et al. | β | 2005 | β |
| Alcohol and aldehyde dehydrogenase polymorphisms in men with type I and Type II alcoholism. | Chai YG et al. | β | 2005 | β |
| Alcoholism: the dissection for endophenotypes. | Hines LM et al. | β | 2005 | β |
| GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride. | Pierucci-Lagha A et al. | β | 2005 | β |
| Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease. | Liu QR et al. | β | 2005 | β |
| Relationships among ventral striatal dopamine release, cortisol secretion, and subjective responses to amphetamine. | Oswald LM et al. | β | 2005 | β |
| The level of response to alcohol in daughters of alcoholics and controls. | Eng MY et al. | β | 2005 | β |
| The role of alcohol and steroid hormones in human aggression. | von der Pahlen B | β | 2005 | β |
| A polymorphism of the mu-opioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humans. | Ray LA et al. | β | 2004 | β |
| Biological and behavioral markers of alcohol sensitivity. | Fromme K et al. | β | 2004 | β |
| Invertebrate models of drug abuse. | Wolf FW et al. | β | 2003 | β |
| Level of response to alcohol measured on the self-rating of the effects of alcohol questionnaire in a group of 40-year-old women. | Schuckit MA et al. | β | 2003 | β |
| NMDA receptor antagonism and the ethanol intoxication signal: from alcoholism risk to pharmacotherapy. | Krystal JH et al. | β | 2003 | β |
| Open field activity and EtOH activation of gamma-PKC null mutants. | Hix DM et al. | β | 2003 | β |
| Subjective intoxication in response to alcohol challenge: heritability and covariation with personality, breath alcohol level, and drinking history. | Viken RJ et al. | β | 2003 | β |
| Biphasic alcohol response differs in heavy versus light drinkers. | King AC et al. | β | 2002 | β |
| A genome-wide search for genes that relate to a low level of response to alcohol. | Schuckit MA et al. | β | 2001 | β |
| Ethanol and neurosteroid interactions in the brain. | Morrow AL et al. | β | 2001 | β |
| Impact of acute and chronic ethanol exposure on prolactin in both male and female rats. | Emanuele NV et al. | β | 2001 | β |
| Analysis of heritability of hormonal responses to alcohol in twins: beta-endorphin as a potential biomarker of genetic risk for alcoholism. | Froehlich JC et al. | β | 2000 | β |
| An etiologic model of alcoholism from a developmental ecological perspective. | Simoneau H et al. | β | 2000 | β |
| Ascertainment of families for a linkage study of alcoholism. | Cook CC et al. | β | 2000 | β |
| Biological phenotypes associated with individuals at high risk for developing alcohol-related disorders. Part 2. | Schuckit MA | β | 2000 | β |
| Children of alcoholics: an update. | Lieberman DZ | β | 2000 | β |
| Genetic control of acute ethanol-induced behaviors in Drosophila. | Singh CM et al. | β | 2000 | β |
| Genetics of the risk for alcoholism. | Schuckit MA | β | 2000 | β |
| Platelet adenylyl cyclase activity as a trait marker of alcohol dependence. WHO/ISBRA Collaborative Study Investigators. International Society for Biomedical Research on Alcoholism. | Menninger JA et al. | β | 2000 | β |
| Subjective and objective responses to ethanol in moderate/heavy and light social drinkers. | Holdstock L et al. | β | 2000 | β |
| Adrenocorticotropin responses to naloxone in sons of alcohol-dependent men. | Wand GS et al. | β | 1999 | β |
| Alcohol, aging, and the stress response. | Spencer RL et al. | β | 1999 | β |
| Issues in the recovery of physicians from addictive illnesses. | Mansky PA | β | 1999 | β |
| Periadolescent nicotine exposure reduces cocaine reward in adult mice. | Kelley BM et al. | β | 1999 | β |
| Postural control and lifetime alcohol consumption in alcohol-dependent patients. | WΓΆber C et al. | β | 1999 | β |
| Treatment interventions-looking towards the millennium. | Crome IB | β | 1999 | β |
| Physiological responses in sons of alcoholics. | Finn PR et al. | β | 1997 | β |
| The Self-Rating of the Effects of alcohol (SRE) form as a retrospective measure of the risk for alcoholism. | Schuckit MA et al. | β | 1997 | β |
| A Long-Term Study of Sons of Alcoholics. | Schuckit MA | β | 1995 | β |
| The Collaborative Study on the Genetics of Alcoholism. | β | β | 1995 | β |