Subjective intoxication in response to alcohol challenge: heritability and covariation with personality, breath alcohol level, and drinking history.
paper
Cited
Public
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- Authors
- Viken, Richard J; Rose, Richard J; Morzorati, Sandra L; Christian, Joe C; Li, Ting-Kai
- Year
- 2003
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 12766624
- DOI
- 10.1097/01.ALC.0000067974.41160.95
BACKGROUND: Numerous studies have identified differences in subjective response to alcohol in subjects differentiated by family history of alcoholism. Results suggest that genetic influences on individual variation in subjective response to alcohol may be a mechanism for genetic effects on alcohol problems. However, direct evidence for genetic effects on subjective response to alcohol is very limited. METHODS: In a sample of 99 adult twin pairs, we studied genetic influences on subjective intoxication after alcohol challenge. The twins ingested a standard dose of ethanol (0.70 g/kg for men/0.65 g/kg for women), and two measures of subjective response to alcohol were assessed. RESULTS: Genetic effects on variation in subjective intoxication reported 1 hr after drinking were significant and substantial: heritability was 0.60 for a 22-item scale and 0.48 for a brief 2-item measure. Self-report measures of neuroticism, psychasthenia, hostility, and family problems shared significant genetic covariation with subjective intoxication. Achieved breath alcohol level, rate of change in breath alcohol on the descending limb, and individual drinking history all shared familial variation with subjective intoxication. No significant genetic effects for subjective intoxication were found 2 hr after drinking, but familial influences remained present, and many of the same personality, drinking history, and breath alcohol variables were predictive of intoxication. CONCLUSIONS: Subjective response to alcohol is heritable, and genetic effects on subjective intoxication are partly shared with genetic effects on personality.
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|---|---|---|---|---|
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| Association Between GABRG2 and Self-Rating of the Effects of Alcohol in a French Young Adult Sample. | Moe JS et al. | — | 2025 | → |
| Inhibitory control in the sober state as a function of alcohol sensitivity: a pilot functional magnetic resonance imaging (fMRI) study. | Cofresí RU et al. | — | 2025 | → |
| The Continuing Challenges of Studying Parallel Behaviours in Humans and Animal Models. | Crombag HS et al. | — | 2025 | → |
| Genetic influences on alcohol sensitivity: A critical review. | Yeung EW et al. | — | 2024 | → |
| Mesocorticolimbic system reactivity to alcohol use-related visual cues as a function of alcohol sensitivity phenotype: A pilot fMRI study. | Cofresí RU et al. | — | 2024 | → |
| Retrospective self-reports of sensitivity to the effects of alcohol: Trait-like stability and concomitant changes with alcohol involvement. | Kohen CB et al. | — | 2024 | → |
| Alcohol craving in the natural environment: Moderating roles of cue exposure, drinking, and alcohol sensitivity. | Kohen CB et al. | — | 2023 | → |
| Subjective response to alcohol: Interactive effects of early life stress, parental risk for mood and substance use disorders, and drinking context. | Kosted R et al. | — | 2023 | → |
| Moderators of subjective response to alcohol in the human laboratory. | Nieto SJ et al. | — | 2022 | → |
| Cross-sectional and prospective associations of drinking characteristics with scores from the Self-Report of the Effects of Alcohol questionnaire and findings from alcohol challenges. | Schuckit MA et al. | — | 2021 | → |
| Effects of alcohol sensitivity on alcohol-induced blackouts and passing out: An examination of the alcohol sensitivity questionnaire among underage drinkers. | Davis CN et al. | — | 2021 | → |
| Genome-wide association studies of the self-rating of effects of ethanol (SRE). | Lai D et al. | — | 2020 | → |
| A prospective study of alcohol involvement and the dual-systems model of adolescent risk-taking during late adolescence and emerging adulthood. | Ellingson JM et al. | — | 2019 | → |
| Evidence for incentive salience sensitization as a pathway to alcohol use disorder. | Cofresí RU et al. | — | 2019 | → |
| Genetics of alcohol use disorder: a review. | Deak JD et al. | — | 2019 | → |
| Performance of the Self-Report of the Effects of Alcohol Questionnaire Across Sexes and Generations. | Schuckit MA et al. | — | 2019 | → |
| Predictors of Increases in Alcohol Problems and Alcohol Use Disorders in Offspring in the San Diego Prospective Study. | Schuckit MA et al. | — | 2019 | → |
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | Schuckit MA | — | 2018 | → |
| Using Placebo Beverages in Group Alcohol Studies. | Bowdring MA et al. | — | 2018 | → |
| A cis-eQTL in OPRM1 is Associated with Subjective Response to Alcohol and Alcohol Use. | Otto JM et al. | — | 2017 | → |
| A prospective study of genetic factors, human laboratory phenotypes, and heavy drinking in late adolescence. | Hendershot CS et al. | — | 2017 | → |
| Examining the sociocultural sensitivity of subjective drunkenness: Comparing Arab and Jewish Israeli pub patrons. | Sznitman SR et al. | — | 2017 | → |
| GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose-Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers. | Yang BZ et al. | — | 2017 | → |
| Rat animal models for screening medications to treat alcohol use disorders. | Bell RL et al. | — | 2017 | → |
| A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction. | Bell RL et al. | — | 2016 | → |
| Alcohol words elicit reactive cognitive control in low-sensitivity drinkers. | Bailey K et al. | — | 2016 | → |
| Experimental psychopathology paradigms for alcohol use disorders: Applications for translational research. | Bujarski S et al. | — | 2016 | → |
| Subjective Response to Alcohol as a Research Domain Criterion. | Ray LA et al. | — | 2016 | → |
| The Ability of Functional Magnetic Resonance Imaging to Predict Heavy Drinking and Alcohol Problems 5 Years Later. | Schuckit MA et al. | — | 2016 | → |
| The natural expression of individual differences in self-reported level of response to alcohol during ecologically assessed drinking episodes. | Trela CJ et al. | — | 2016 | → |
| Different Subjective and Objective Responses to Alcohol Among Heavy and Light Drinkers of Han and Uyghur Nationalities in China. | Hu HX et al. | — | 2015 | → |
| Subjective response as a consideration in the pharmacogenetics of alcoholism treatment. | Roche DJ et al. | — | 2015 | → |
| Alcohol cues, approach bias, and inhibitory control: applying a dual process model of addiction to alcohol sensitivity. | Fleming KA et al. | — | 2014 | → |
| Genetic influences on alcohol-related hangover. | Slutske WS et al. | — | 2014 | → |
| Heritability of usual alcohol intoxication and hangover in male twins: the NAS-NRC Twin Registry. | Wu SH et al. | — | 2014 | → |
| How do we 'learn' addiction? Risk factors and mechanisms getting addicted to alcohol. | Hägele C et al. | — | 2014 | → |
| Initial subjective reward: single-exposure conditioned place preference to alcohol in mice. | Grisel JE et al. | — | 2014 | → |
| Consensus paper of the WFSBP task force on biological markers: biological markers for alcoholism. | Hashimoto E et al. | — | 2013 | → |
| Differences in acute response to alcohol between African Americans and European Americans. | Pedersen SL et al. | — | 2013 | → |
| Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity. | Bell RL et al. | — | 2012 | → |
| fMRI differences between subjects with low and high responses to alcohol during a stop signal task. | Schuckit MA et al. | — | 2012 | → |
| Heritability of level of response and association with recent drinking history in nonalcohol-dependent drinkers. | Kalu N et al. | — | 2012 | → |
| Sex differences in how a low sensitivity to alcohol relates to later heavy drinking. | Schuckit MA et al. | — | 2012 | → |
| Critical thoughts on current rodent models for evaluating potential treatments of alcohol addiction and withdrawal. | Ripley TL et al. | — | 2011 | → |
| Role of GABRA2 in moderating subjective responses to alcohol. | Roh S et al. | — | 2011 | → |
| Self-Rating of the Effects of Alcohol (SRE): Predictive utility and reliability across interview and self-report administrations. | Ray LA et al. | — | 2011 | → |
| Does coping mediate the relationship between personality and cardiovascular health in African Americans? | Whitfield KE et al. | — | 2010 | → |
| Human and laboratory rodent low response to alcohol: is better consilience possible? | Crabbe JC et al. | — | 2010 | → |
| Socioeconomic status moderates the association between John Henryism and NEO PI-R personality domains. | Stanton MV et al. | — | 2010 | → |
| Subjective responses to alcohol consumption as endophenotypes: advancing behavioral genetics in etiological and treatment models of alcoholism. | Ray LA et al. | — | 2010 | → |
| A major QTL for acute ethanol sensitivity in the alcohol tolerant and non-tolerant selected rat lines. | Radcliffe RA et al. | — | 2009 | → |
| An examination of subjective response to alcohol in African Americans. | Pedersen SL et al. | — | 2009 | → |
| Catching the alcohol buzz: an examination of the latent factor structure of subjective intoxication. | Ray LA et al. | — | 2009 | → |
| Does lower response to alcohol explain the high co-morbidity between bipolar disorder and alcohol dependence? | Le Strat Y et al. | — | 2008 | → |
| Examining the heritability of a laboratory-based smoking endophenotype: initial results from an experimental twin study. | Ray LA et al. | — | 2007 | → |
| Beyond the DSM: defining endophenotypes for genetic studies of substance abuse. | Frederick JA et al. | — | 2006 | → |
| Challenges in genetic studies of the etiology of substance use and substance use disorders: introduction to the special issue. | Prescott CA et al. | — | 2006 | → |
| Confirmation of quantitative trait loci for ethanol sensitivity and neurotensin receptor density in crosses derived from the inbred high and low alcohol sensitive selectively bred rat lines. | Radcliffe RA et al. | — | 2006 | → |
| How many drinks does it take you to feel drunk? Trends and predictors for subjective drunkenness. | Kerr WC et al. | — | 2006 | → |
| A cross-generational comparison of alcohol challenges at about age 20 in 40 father-offspring pairs. | Schuckit MA et al. | — | 2005 | → |
| Alcoholism: the dissection for endophenotypes. | Hines LM et al. | — | 2005 | → |
| An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. | Hu X et al. | — | 2005 | → |
| Breath ethanol and acetone as indicators of serum glucose levels: an initial report. | Galassetti PR et al. | — | 2005 | → |
| GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride. | Pierucci-Lagha A et al. | — | 2005 | → |
| The level of response to alcohol in daughters of alcoholics and controls. | Eng MY et al. | — | 2005 | → |
| Alcoholism: genes and mechanisms. | Oroszi G et al. | — | 2004 | → |
| A polymorphism of the mu-opioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humans. | Ray LA et al. | — | 2004 | → |
| Findings across subgroups regarding the level of response to alcohol as a risk factor for alcohol use disorders: a college population of women and Latinos. | Schuckit MA et al. | — | 2004 | → |
| Testing the level of response to alcohol: social information processing model of alcoholism risk--a 20-year prospective study. | Schuckit MA et al. | — | 2004 | → |
| The search for genes contributing to the low level of response to alcohol: patterns of findings across studies. | Schuckit MA et al. | — | 2004 | → |
| Microdialysis for the determination of acetaldehyde and ethanol concentrations in the striatum of freely moving rats. | Jamal M et al. | — | 2003 | → |