The cannabinoid receptor: biochemical, anatomical and behavioral characterization.
paper
Cited
Public
Unavailable
- Authors
- Howlett, A C; Bidaut-Russell, M; Devane, W A; Melvin, L S; Johnson, M R; Herkenham, M
- Year
- 1990
- Journal
- Trends in neurosciences
- PMID
- 1700516
- DOI
- 10.1016/0166-2236(90)90124-s
The actions of the active principle of marihuana, delta 9-tetrahydrocannabinol, are mimicked by synthetic cannabinoid agonists showing high potency and enantio-selectivity in behavioral assays. These drugs have been used to characterize cannabinoid receptor binding, biochemistry and pharmacology, leading to a better understanding of the effects of cannabinoids in the CNS of humans and experimental animals.
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| Suppression of noxious stimulus-evoked activity in the ventral posterolateral nucleus of the thalamus by a cannabinoid agonist: correlation between electrophysiological and antinociceptive effects. | Martin WJ et al. | โ | 1996 | โ |
| The conformational properties of the highly selective cannabinoid receptor ligand CP-55,940. | Xie XQ et al. | โ | 1996 | โ |
| Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization. | Desarnaud F et al. | โ | 1995 | โ |
| Arachidonoyl ethanolamide-[1,2-14C] as a substrate for anandamide amidase. | Omeir RL et al. | โ | 1995 | โ |
| Cannabinoids selectively decrease paired-pulse facilitation of perforant path synaptic potentials in the dentate gyrus in vitro. | Kirby MT et al. | โ | 1995 | โ |
| Changes in rat brain cannabinoid binding sites after acute or chronic exposure to their endogenous agonist, anandamide, or to delta 9-tetrahydrocannabinol. | Romero J et al. | โ | 1995 | โ |
| Effect of delta 9-tetrahydrocannabinol on short-term memory in the rat. | Molina-Holgado F et al. | โ | 1995 | โ |
| Morbid risk of schizophrenia for relatives of patients with cannabis-associated psychosis. | McGuire PK et al. | โ | 1995 | โ |
| The ontogeny of cannabinoid receptors in the brain of postnatal and aging rats. | Belue RC et al. | โ | 1995 | โ |
| Time-course of the effects of anandamide, the putative endogenous cannabinoid receptor ligand, on extrapyramidal function. | Romero J et al. | โ | 1995 | โ |
| Cannabinoid receptor binding and messenger RNA expression in human brain: an in vitro receptor autoradiography and in situ hybridization histochemistry study of normal aged and Alzheimer's brains. | Westlake TM et al. | โ | 1994 | โ |
| Discriminative stimulus- and open-field effects of the enantiomers of 11-hydroxy-delta-8-tetrahydrocannabinol in pigeons and gerbils. | Jรคrbe TU et al. | โ | 1994 | โ |
| Downregulation of rat brain cannabinoid binding sites after chronic delta 9-tetrahydrocannabinol treatment. | Rodrรญguez de Fonseca F et al. | โ | 1994 | โ |
| Enzymatic synthesis of anandamide, an endogenous ligand for the cannabinoid receptor, by brain membranes. | Devane WA et al. | โ | 1994 | โ |
| Inhibitors of arachidonoyl ethanolamide hydrolysis. | Koutek B et al. | โ | 1994 | โ |
| Motor behavior and nigrostriatal dopaminergic activity in adult rats perinatally exposed to cannabinoids. | Navarro M et al. | โ | 1994 | โ |
| New dawn of cannabinoid pharmacology. | Devane WA | โ | 1994 | โ |
| Possible role of the cytochrome P450-linked monooxygenase system in preventing delta 9-tetrahydrocannabinol-induced stimulation of tuberoinfundibular dopaminergic activity in female rats. | Bonnin A et al. | โ | 1994 | โ |
| Search for endogenous ligands of the cannabinoid receptor. | Mechoulam R et al. | โ | 1994 | โ |
| (+)-WIN 55,212-2, a novel cannabinoid receptor agonist, exerts antidystonic effects in mutant dystonic hamsters. | Richter A et al. | โ | 1994 | โ |
| An acute dose of delta 9-tetrahydrocannabinol affects behavioral and neurochemical indices of mesolimbic dopaminergic activity. | Navarro M et al. | โ | 1993 | โ |
| Antinociceptive actions of cannabinoids following intraventricular administration in rats. | Martin WJ et al. | โ | 1993 | โ |
| Chronic cannabinoid administration alters cannabinoid receptor binding in rat brain: a quantitative autoradiographic study. | Oviedo A et al. | โ | 1993 | โ |
| delta 9-Tetrahydrocannabinol affects mesolimbic dopaminergic activity in the female rat brain: interactions with estrogens. | Bonnin A et al. | โ | 1993 | โ |
| Discriminative stimulus effects of delta 9-tetrahydrocannabinol and delta 9-11-tetrahydrocannabinol in rats and rhesus monkeys. | Wiley JL et al. | โ | 1993 | โ |
| Identification of cannabinoid receptors in cultures of rat cerebellar granule cells. | Pacheco MA et al. | โ | 1993 | โ |
| Localization of cannabinoid receptor mRNA in rat brain. | Matsuda LA et al. | โ | 1993 | โ |
| Molecular characterization of a peripheral receptor for cannabinoids. | Munro S et al. | โ | 1993 | โ |
| Motor disturbances induced by an acute dose of delta 9-tetrahydrocannabinol: possible involvement of nigrostriatal dopaminergic alterations. | Navarro M et al. | โ | 1993 | โ |
| Ca(2+)-dependent release from rat brain of cannabinoid receptor binding activity. | Evans DM et al. | โ | 1992 | โ |
| Cannabinoid receptor agonists inhibit Ca current in NG108-15 neuroblastoma cells via a pertussis toxin-sensitive mechanism. | Caulfield MP et al. | โ | 1992 | โ |
| Cannabinoid receptor localization in brain: relationship to motor and reward systems. | Herkenham M | โ | 1992 | โ |
| Distribution of cannabinoid receptor messenger RNA in the human brain: an in situ hybridization histochemistry with oligonucleotides. | Mailleux P et al. | โ | 1992 | โ |
| Distribution of cannabinoid receptors in rat brain determined with aminoalkylindoles. | Jansen EM et al. | โ | 1992 | โ |
| Distribution of neuronal cannabinoid receptor in the adult rat brain: a comparative receptor binding radioautography and in situ hybridization histochemistry. | Mailleux P et al. | โ | 1992 | โ |
| Estrogenic modulation of delta(9)-Tetrahydrocannabinol effects on nigrostriatal dopaminergic activity in the female rat brain. | Bonnin A et al. | โ | 1992 | โ |
| Initial observations on the distribution of cannabinoid receptor binding sites in the human adult basal ganglia using autoradiography. | Mailleux P et al. | โ | 1992 | โ |
| Localization of cannabinoid receptor in the human developing and adult basal ganglia. Higher levels in the striatonigral neurons. | Mailleux P et al. | โ | 1992 | โ |
| Neurobiology of marijuana abuse. | Abood ME et al. | โ | 1992 | โ |
| Cannabinoids and the hippocampal glucocorticoid receptor: recent findings and possible significance. | Eldridge JC et al. | โ | 1991 | โ |
| Chronic exposure to delta 9-tetrahydrocannabinol fails to irreversibly alter brain cannabinoid receptors. | Westlake TM et al. | โ | 1991 | โ |
| Effects of pre- and perinatal exposure to hashish extracts on the ontogeny of brain dopaminergic neurons. | Rodrรญguez de Fonseca F et al. | โ | 1991 | โ |
| Molecular cloning of a human cannabinoid receptor which is also expressed in testis. | Gรฉrard CM et al. | โ | 1991 | โ |
| Neuronal localization of cannabinoid receptors and second messengers in mutant mouse cerebellum. | Herkenham M et al. | โ | 1991 | โ |
| The cannabinoid receptor: biochemical and cellular properties in neuroblastoma cells. | Howlett AC et al. | โ | 1991 | โ |
| Reverse pharmacology applied to the cannabinoid receptor. | Howlett AC | โ | 1990 | โ |