Adolescence and the trajectory of alcohol use: basic to clinical studies.
paper
Cited
Public
Unavailable
- Authors
- Brown, Sandra A; Tapert, Susan F
- Year
- 2004
- Journal
- Annals of the New York Academy of Sciences
- PMID
- 15251893
- DOI
- 10.1196/annals.1308.028
Emerging findings from developmentally focused research indicates subtle but important neurocognitive disadvantages among adolescents with alcohol-use disorders (AUD) as compared to teens without AUD. Even after 3 weeks of abstinence AUD youth display a 10% decrement in delayed memory functions. Neuropsychological testing of youth followed at 4 and 8 years demonstrates that heavy drinking during adolescence is associated with diminished retrieval of verbal and nonverbal material, and poorer performance on tests requiring attention skills. Alcohol withdrawal over the teen years appears to uniquely contribute to deterioration in functioning in visuospatial tasks. Brain imaging studies suggest reduced hippocampal volumes, white matter microstructure irregularities, brain response abnormalities while performing challenging cognitive tasks, and enhanced brain response when viewing alcohol cues (i.e., alcohol advertisements) among adolescents with AUD. Family characteristics such as history of alcoholism and socioeconomic status as well as personal features, including adolescent psychopathology, gender, and age of onset must be carefully considered when investigating the influence of teenage drinking on neurocognition. Further research is needed to understand how age at onset of drinking and duration of abstinence at the time of assessment affect cognitive findings. Longitudinal studies are needed to clarify neuromaturational changes associated with early alcohol exposure and patterns of resiliency. Although the magnitude of alcohol-related effects observed in adolescents' neurocognition is relatively modest, the implications are major given the prevalence of alcohol involvement, and the important educational, occupational, and social transitions that occur during adolescence.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Brain network features predating early alcohol initiation in adolescence. | Byrne H et al. | — | 2026 | → |
| 'SASADECC'-A Unique Model of Collaborative Care Between Government and Non-Government Health Services for Adolescents With Complex Substance Use Issues. | Gordon DEA et al. | — | 2026 | → |
| Adolescent alcohol exposure disrupts episodic-like memory by impairing dopamine synapses in the mouse prelimbic cortex. | Seiglie MP et al. | — | 2025 | → |
| Alcohol Abuse and Prospective Memory in Young Adults With and Without Childhood Trauma: The Moderating Role of Psychological Inflexibility. | Agrawal S et al. | — | 2025 | → |
| Developmental trajectory of voluntary alcohol consumption in adolescent mice using finite mixture modeling and Bayesian posterior probability analysis. | Yu N et al. | — | 2025 | → |
| Structural Covariance Network Properties Predictive of Early Adolescent Alcohol Initiation | Byrne H et al. | — | 2025 | — |
| Adolescent binge ethanol impacts H3K9me3-occupancy at synaptic genes and the regulation of oligodendrocyte development. | Brocato ER et al. | — | 2024 | → |
| A longitudinal study of the relationship between alcohol-related blackouts and attenuated structural brain development. | Lorkiewicz SA et al. | — | 2024 | → |
| Prevalence and psycho-social factors associated with alcohol use among primary school-going children aged 6 to 13 years in Mbale district, Uganda: a cross-sectional study. | Nalugya JS et al. | — | 2024 | → |
| The combination of donepezil and cognitive training for improving treatment outcomes for alcohol use disorder: Design of a randomized controlled trial. | Yoon G et al. | — | 2024 | → |
| Time to reconsider the best practice models of substance use care for young people. | Moensted ML et al. | — | 2024 | → |
| Alcohol Intake and Academic Performance and Dropout in High School: A Prospective Cohort Study in 65,233 Adolescents. | Hjarnaa L et al. | — | 2023 | → |
| Evaluating effects of IBEM-U on decreasing alcohol consumption and heavy episodic drinking among university students in Colombia: Protocol for a randomized control trial. | Mejía-Trujillo J et al. | — | 2023 | → |
| Fetal alcohol spectrum disorders. | Popova S et al. | — | 2023 | → |
| "If my buddies use drugs, will I?" Peer effects on Substance Consumption Among Teenagers. | Lopez-Mayan C et al. | — | 2023 | → |
| Successful word retraining, maintenance and transference of practice to everyday activities: A single case experimental design in early onset alcohol-induced brain damage. | Savage SA et al. | — | 2023 | → |
| A Longitudinal Examination of Alcohol-Related Blackouts as a Predictor of Changes in Learning, Memory, and Executive Function in Adolescents. | Lorkiewicz SA et al. | — | 2022 | → |
| Identification of clinical factors related to prediction of alcohol use disorder from electronic health records using feature selection methods. | Ebrahimi A et al. | — | 2022 | → |
| Testing mediational processes of substance use relapse among youth who participated in a mobile texting aftercare project. | Gonzales-Castaneda R et al. | — | 2022 | → |
| The effect of impulsivity and drinking motives on alcohol outcomes in college students: a 3-year longitudinal analysis. | Fisher S et al. | — | 2022 | → |
| Trajectories of brain development reveal times of risk and factors promoting resilience to alcohol use during adolescence. | Lannoy S et al. | — | 2021 | → |
| Aberrations in Incentive Learning and Responding to Heroin in Male Rats After Adolescent or Adult Chronic Binge-Like Alcohol Exposure. | Galaj E et al. | — | 2020 | → |
| Binge drinking is associated with altered resting state functional connectivity of reward-salience and top down control networks. | Arienzo D et al. | — | 2020 | → |
| Incubation of Negative Affect during Protracted Alcohol Withdrawal Is Age-, but Not Sex-Selective. | Jimenez Chavez CL et al. | — | 2020 | → |
| Alcohol Use by Youth. | Ryan SA et al. | — | 2019 | → |
| Associations Among Attention Problems, Learning Strategies, and Hazardous Drinking Behavior in a College Student Sample: A Pilot Study. | Bolden J | — | 2019 | → |
| Cannabis Use and Consequences. | Mashhoon Y et al. | — | 2019 | → |
| African American emerging adults' experiences with racial discrimination and drinking habits: The moderating roles of perceived stress. | Metzger IW et al. | — | 2018 | → |
| Recovery schools for improving behavioral and academic outcomes among students in recovery from substance use disorders: a systematic review. | Hennessy EA et al. | — | 2018 | → |
| The impact of adolescent stress experiences on neurobiological development. | Lo Iacono L et al. | — | 2018 | → |
| The relationship between Australian harm minimisation alcohol education and student uptake, consumption and harm. | Midford R et al. | — | 2018 | → |
| An examination of the impact of maladaptive coping on the association between stressor type and alcohol use in college. | Metzger IW et al. | — | 2017 | → |
| Binge drinking during adolescence and young adulthood is associated with deficits in verbal episodic memory. | Carbia C et al. | — | 2017 | → |
| Effect of Victimization on Impulse Control and Binge Drinking among Serious Juvenile Offenders from Adolescence to Young Adulthood. | Davis JP et al. | — | 2017 | → |
| New Implications for the Melanocortin System in Alcohol Drinking Behavior in Adolescents: The Glial Dysfunction Hypothesis. | Orellana JA et al. | — | 2017 | → |
| Risk-Taking Propensity in Older Adolescents: Internalizing Symptoms, Gender, and Negative Reinforcement. | Dahne J et al. | — | 2017 | → |
| Does Skipping Breakfast and Being Overweight Influence Academic Achievement Among Korean Adolescents? | Kang YW et al. | — | 2016 | → |
| How to study sex differences in addiction using animal models. | Carroll ME et al. | — | 2016 | → |
| Long-Lasting Effects of Chronic Intermittent Alcohol Exposure in Adolescent Mice on Object Recognition and Hippocampal Neuronal Activity. | Beaudet G et al. | — | 2016 | → |
| Neurodevelopmental Precursors and Consequences of Substance Use during Adolescence: Promises and Pitfalls of Longitudinal Neuroimaging Strategies. | Fishbein DH et al. | — | 2016 | → |
| Prefrontal mechanisms of comorbidity from a transdiagnostic and ontogenic perspective. | Macdonald AN et al. | — | 2016 | → |
| Codevelopment of psychopathic features and alcohol use during emerging adulthood: Disaggregating between- and within-person change. | Hawes SW et al. | — | 2015 | → |
| Commentary: sex differences in the pathways to symptoms of alcohol use disorder: a study of opposite-sex twin pairs. | Kapoor M et al. | — | 2015 | → |
| Ethanol during adolescence decreased the BDNF levels in the hippocampus in adult male Wistar rats, but did not alter aggressive and anxiety-like behaviors. | Scheidt L et al. | — | 2015 | → |
| Experimentation versus progression in adolescent drug use: A test of an emerging neurobehavioral imbalance model. | Khurana A et al. | — | 2015 | → |
| Maternal risk taking on the balloon analogue risk task as a prospective predictor of youth alcohol use escalation. | Banducci AN et al. | — | 2015 | → |
| Sex Differences in Behavioral Dyscontrol: Role in Drug Addiction and Novel Treatments. | Carroll ME et al. | — | 2015 | → |
| Withdrawal from Chronic Alcohol Induces a Unique CCL2 mRNA Increase in Adolescent But Not Adult Brain--Relationship to Blood Alcohol Levels and Seizures. | Harper KM et al. | — | 2015 | → |
| Adolescent heavy episodic drinking: neurocognitive functioning during early abstinence. | Winward JL et al. | — | 2014 | → |
| Alcohol use disorder in women: Risks and consequences of an adolescent onset and persistent course. | Foster KT et al. | — | 2014 | → |
| Bioinformatics analyses reveal age-specific neuroimmune modulation as a target for treatment of high ethanol drinking. | Agrawal RG et al. | — | 2014 | → |
| Early adolescent symptoms of social phobia prospectively predict alcohol use. | Dahne J et al. | — | 2014 | → |
| Effects of ethanol exposure during adolescence or in adulthood on Pavlovian conditioned approach in Sprague-Dawley rats. | McClory AJ et al. | — | 2014 | → |
| GABAergic contributions to alcohol responsivity during adolescence: insights from preclinical and clinical studies. | Silveri MM | — | 2014 | → |
| Heavy alcohol use, marijuana use, and concomitant use by adolescents are associated with unique and shared cognitive decrements. | Winward JL et al. | — | 2014 | → |
| Substance Use and Associated Health Conditions throughout the Lifespan. | Schulte MT et al. | — | 2014 | → |
| Work stress and alcohol consumption among adolescents: moderation by family and peer influences. | Liu XC et al. | — | 2014 | → |
| Adolescence and Alcohol: a review of the literature. | Skala K et al. | — | 2013 | → |
| Alcohol and other drug use, club drug dependence and treatment seeking among lesbian, gay and bisexual young people in Sydney. | Lea T et al. | — | 2013 | → |
| Alcohol and young people: what the legislation says about access and secondary supply. | Roche AM et al. | — | 2013 | → |
| Conduct disorder and initiation of substance use: a prospective longitudinal study. | Hopfer C et al. | — | 2013 | → |
| Consequences of ethanol exposure on cued and contextual fear conditioning and extinction differ depending on timing of exposure during adolescence or adulthood. | Broadwater M et al. | — | 2013 | → |
| Early adolescent growth in depression and conduct problem symptoms as predictors of later substance use impairment. | McCarty CA et al. | — | 2013 | → |
| Effects of a persistent binge drinking pattern of alcohol consumption in young people: a follow-up study using event-related potentials. | López-Caneda E et al. | — | 2013 | → |
| Future directions in the developmental science of addictions. | Hussong AM et al. | — | 2013 | → |
| Heterogeneity in growth and desistance of alcohol use for men in their 20s: prediction from early risk factors and association with treatment. | Capaldi DM et al. | — | 2013 | → |
| Pathways to alcohol-induced brain impairment in young people: a review. | Hermens DF et al. | — | 2013 | → |
| Working memory ability predicts trajectories of early alcohol use in adolescents: the mediational role of impulsivity. | Khurana A et al. | — | 2013 | → |
| Chronic ethanol exposure during adolescence alters the behavioral responsiveness to ethanol in adult mice. | Quoilin C et al. | — | 2012 | → |
| Developmental alcohol-specific parenting profiles in adolescence and their relationships with adolescents' alcohol use. | Koning IM et al. | — | 2012 | → |
| Early attentional modulation by alcohol-related cues in young binge drinkers: an event-related potentials study. | Petit G et al. | — | 2012 | → |
| Experimental psychiatric illness and drug abuse models: from human to animal, an overview. | Edwards S et al. | — | 2012 | → |
| Hyperactivation of right inferior frontal cortex in young binge drinkers during response inhibition: a follow-up study. | López-Caneda E et al. | — | 2012 | → |
| Increased amplitude of P3 event-related potential in young binge drinkers. | Crego A et al. | — | 2012 | → |
| Know your limits: awareness of the 2009 Australian alcohol guidelines among young people. | Bowring AL et al. | — | 2012 | → |
| Adolescents at risk for alcohol abuse demonstrate altered frontal lobe activation during Stroop performance. | Silveri MM et al. | — | 2011 | → |
| Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse. | Breese GR et al. | — | 2011 | → |
| Critical age windows for neurodevelopmental psychiatric disorders: evidence from animal models. | Marco EM et al. | — | 2011 | → |
| Drugs as instruments from a developmental child and adolescent psychiatric perspective. | Banaschewski T et al. | — | 2011 | → |
| Early adolescent executive functioning, intrauterine exposures and own drug use. | Rose-Jacobs R et al. | — | 2011 | → |
| Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain. | Alfonso-Loeches S et al. | — | 2011 | → |
| Neurobehavioral adaptations to methylphenidate: the issue of early adolescent exposure. | Marco EM et al. | — | 2011 | → |
| Does adolescent alcohol and marijuana use predict suppressed growth in psychosocial maturity among male juvenile offenders? | Chassin L et al. | — | 2010 | → |
| Effects of ethanol on hippocampal function during adolescence: a look at the past and thoughts on the future. | Chin VS et al. | — | 2010 | → |
| Genetic and environmental risk factors for adolescent-onset substance use disorders. | Meyers JL et al. | — | 2010 | → |
| Mechanisms involved in the neurotoxic, cognitive, and neurobehavioral effects of alcohol consumption during adolescence. | Guerri C et al. | — | 2010 | → |
| Mothers' intentions to introduce their adolescent to alcohol use: does mothers' alcohol use effect intentions? | Roberts R et al. | — | 2010 | → |
| Neurobiology of the adolescent brain and behavior: implications for substance use disorders. | Casey BJ et al. | — | 2010 | → |
| Neuropsychological performance of South African treatment-naïve adolescents with alcohol dependence. | Ferrett HL et al. | — | 2010 | → |
| Protective strategies: a mediator of risk associated with age of drinking onset. | Palmer RS et al. | — | 2010 | → |
| Role of central nervous system insulin resistance in fetal alcohol spectrum disorders. | de la Monte SM et al. | — | 2010 | → |
| Tobacco and alcohol consumption among adolescents. | Ferreira MM et al. | — | 2010 | → |
| A developmental perspective on underage alcohol use. | Masten AS et al. | — | 2009 | → |
| Alcohol environments and disparities in exposure associated with adolescent drinking in California. | Truong KD et al. | — | 2009 | → |
| Binge drinking affects attentional and visual working memory processing in young university students. | Crego A et al. | — | 2009 | → |
| Functional brain imaging of development-related risk and vulnerability for substance use in adolescents. | Hardin MG et al. | — | 2009 | → |
| Gender differences in factors influencing alcohol use and drinking progression among adolescents. | Schulte MT et al. | — | 2009 | → |
| Teenage drinking, alcohol availability and pricing: a cross-sectional study of risk and protective factors for alcohol-related harms in school children. | Bellis MA et al. | — | 2009 | → |
| The heritability of P300 amplitude in 18-year-olds is robust to adolescent alcohol use. | Perlman G et al. | — | 2009 | → |
| Affective circuitry and risk for alcoholism in late adolescence: differences in frontostriatal responses between vulnerable and resilient children of alcoholic parents. | Heitzeg MM et al. | — | 2008 | → |
| Alcohol in emerging adulthood: 7-year study of problem and dependent drinkers. | Delucchi KL et al. | — | 2008 | → |
| Behavioral responses during the initial exposures to a low dose of cocaine in late preweanling and adult rats. | Smith KS et al. | — | 2008 | → |
| Early alcohol experiences and adolescent mental health: a population-based study in Taiwan. | Chen CY et al. | — | 2008 | → |
| Emergence of NMDAR-independent long-term potentiation at hippocampal CA1 synapses following early adolescent exposure to chronic intermittent ethanol: role for sigma-receptors. | Sabeti J et al. | — | 2008 | → |
| Influence of chronic alcohol consumption on inward rectifier potassium channels in cerebral arterioles. | Sun H et al. | — | 2008 | → |
| Self-concept disturbances: cognitive vulnerability for early drinking and early drunkenness in adolescents at high risk for alcohol problems. | Corte C et al. | — | 2008 | → |
| The adolescent origins of substance use disorders. | McGue M et al. | — | 2008 | → |
| Underage drinking: a developmental framework. | Masten AS et al. | — | 2008 | → |
| Why do many psychiatric disorders emerge during adolescence? | Paus T et al. | — | 2008 | → |
| Working memory capacity moderates the predictive effects of drug-related associations on substance use. | Grenard JL et al. | — | 2008 | → |
| Adolescence, glucocorticoids and alcohol. | Prendergast MA et al. | — | 2007 | → |
| Comparison of infant and adult rats in exploratory activity, diurnal patterns, and responses to novel and anxiety-provoking environments. | Smith KS et al. | — | 2007 | → |
| Delinquency as a mediator of the relation between negative affectivity and adolescent alcohol use disorder. | Shoal GD et al. | — | 2007 | → |
| Early drinking and the development of alcoholism: a commentary on Sartor et al. (2007). | McGue M | — | 2007 | → |
| Early onset problem behavior, young adult psychopathology, and contextual risk. | Keyes MA et al. | — | 2007 | → |
| Evidence of association between early alcohol use and risk of later problems. | Vieira DL et al. | — | 2007 | → |
| Exposure to alcohol use in motion pictures and teen drinking in Germany. | Hanewinkel R et al. | — | 2007 | → |
| Intermittent ethanol exposure induces inflammatory brain damage and causes long-term behavioural alterations in adolescent rats. | Pascual M et al. | — | 2007 | → |
| Substance use and the adolescent brain: a toxic combination? | Lubman DI et al. | — | 2007 | → |
| A low chronic ethanol exposure induces morphological changes in the adolescent rat brain that are not fully recovered even after a long abstinence: an immunohistochemical study. | Evrard SG et al. | — | 2006 | → |
| Periadolescent exposure to ethanol and diazepam alters the aversive properties of ethanol in adult mice. | Graham DL et al. | — | 2006 | → |
| Substance use, academic performance and the village school. | Harrington Godley S | — | 2006 | → |
| The alcoholism generator. | Miller MW et al. | — | 2006 | → |
| The association of early adolescent problem behavior and adult psychopathology: a multivariate behavioral genetic perspective. | McGue M et al. | — | 2006 | → |
| Influence of age at drinking onset on long-term ethanol self-administration with deprivation and stress phases. | Siegmund S et al. | — | 2005 | → |
| Preventing alcohol misuse among adolescents. | Bernstein E et al. | — | 2005 | → |
| Adolescence and the trajectory of alcohol use: introduction to part VI. | Spear LP | — | 2004 | → |
| Trajectories of alcohol use and electrophysiological and morphological indices of brain development: distinguishing causes from consequences. | Hill SY | — | 2004 | → |