Association between GABRA1 and drinking behaviors in the collaborative study on the genetics of alcoholism sample.
paper
Primary
Public
Unavailable
- Authors
- Dick, Danielle M; Plunkett, Jevon; Wetherill, Leah Flury; Xuei, Xiaoling; Goate, Alison; Hesselbrock, Victor; Schuckit, Marc; Crowe, Raymond; Edenberg, Howard J; Foroud, Tatiana
- Year
- 2006
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 16792556
- DOI
- 10.1111/j.1530-0277.2006.00136.x
BACKGROUND: A wealth of literature supports the role of gamma-aminobutyric acid (GABA) in neurobiological pathways contributing to alcohol dependence and related phenotypes. Animal studies have consistently tied rodent homologs of the GABAA receptor genes on human chromosome 5q to alcohol-related behaviors; however, human studies have produced mixed results. Family-based association analyses previously conducted in the Collaborative Study on the Genetics of Alcoholism (COGA) sample yielded no evidence of association with Diagnostic and Statistical Manual of Mental Disorder-fourth edition (DSM-IV) alcohol dependence and these genes. As a follow-up to that study, we examined several alcohol-related behaviors in the COGA sample as follows: (1) a broader definition of alcohol dependence, including DSM-III-R symptoms and Feighner criteria (referred to as COGA alcohol dependence); (2) withdrawal; (3) history of alcohol-induced blackouts; (4) level of response to alcohol; (5) age of onset of regular drinking; and (6) age at first drunkenness. METHODS: Family-based association tests were conducted, using multiple single-nucleotide polymorphisms (SNPs) in each of the 4 GABAA receptor genes on chromosome 5q. RESULTS: In GABRA1, we found evidence of association with several of the drinking behavior phenotypes, including COGA alcohol dependence, history of blackouts, age at first drunkenness, and level of response to alcohol. We did not find consistent evidence of association with the remaining genes and any of the phenotypes. CONCLUSIONS: We found evidence for association between GABRA1 and COGA alcohol dependence, history of blackouts, age at first drunkenness, and level of response to alcohol. These analyses suggest that efforts to characterize genetic contributions to alcohol dependence may benefit by examining alcohol-related behaviors in addition to clinical alcohol dependence diagnoses.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Association Between GABRG2 and Self-Rating of the Effects of Alcohol in a French Young Adult Sample. | Moe JS et al. | β | 2025 | β |
| Analytical description of adolescent binge drinking patients. | Haas C et al. | β | 2023 | β |
| Cross-disorder GWAS meta-analysis of endocannabinoid DNA variations in major depressive disorder, bipolar disorder, attention deficit hyperactivity disorder, autism spectrum disorder, and schizophrenia. | Kim HK et al. | β | 2023 | β |
| AUD Risk, Diagnoses, and Course in a Prospective Study Across Two Generations: Implications for Prevention. | Schuckit MA | β | 2022 | β |
| A standardized polyherbal preparation POL-6 diminishes alcohol withdrawal anxiety by regulating Gabra1, Gabra2, Gabra3, Gabra4, Gabra5 gene expression of GABA<sub>A</sub> receptor signaling pathway in rats. | Sharma L et al. | β | 2021 | β |
| Comparing the potential causal influence of two indicators of early alcohol use on later alcohol use disorder symptoms. | Davis CN et al. | β | 2020 | β |
| Sex Differences in the Expression of the Ξ±5 Subunit of the GABA<sub>A</sub> Receptor in Alcoholics with and without Cirrhosis of the Liver. | Janeczek P et al. | β | 2020 | β |
| Bacopa monnieri abrogates alcohol abstinence-induced anxiety-like behavior by regulating biochemical and Gabra1, Gabra4, Gabra5 gene expression of GABA<sub>A</sub> receptor signaling pathway in rats. | Gupta GL et al. | β | 2019 | β |
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | Schuckit MA | β | 2018 | β |
| An exploratory study of candidate gene(s) for Delirium Tremens: Adding the new cholinergic dimension to the conundrum. | Malhotra S et al. | β | 2018 | β |
| Severe acute alcoholic hepatitis and liver transplant: A never-ending mournful story. | Obed A et al. | β | 2018 | β |
| GABA<sub>A</sub> receptor subtype involvement in addictive behaviour. | Stephens DN et al. | β | 2017 | β |
| Promising pharmacogenetic targets for treating alcohol use disorder: evidence from preclinical models. | Rinker JA et al. | β | 2017 | β |
| A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction. | Bell RL et al. | β | 2016 | β |
| Candidate genes for alcohol dependence: A genetic association study from India. | Malhotra S et al. | β | 2016 | β |
| miR-181a is a negative regulator of GRIA2 in methamphetamine-use disorder. | Zhang K et al. | β | 2016 | β |
| Need for power in genetic explorations of alcoholism in India. | Mysore VA | β | 2016 | β |
| Polymorphism rs4263535 in GABRA1 intron 4 was related to deeper sedation by intravenous midazolam. | Choi YJ et al. | β | 2015 | β |
| A brief history of research on the genetics of alcohol and other drug use disorders. | Schuckit MA | β | 2014 | β |
| Association of gamma-aminobutyric acid A receptor Ξ±2 gene (GABRA2) with alcohol use disorder. | Li D et al. | β | 2014 | β |
| GABAergic contributions to alcohol responsivity during adolescence: insights from preclinical and clinical studies. | Silveri MM | β | 2014 | β |
| GABA Receptors Genes Polymorphisms and Alcohol Dependence: No Evidence of an Association in an Italian Male Population. | Terranova C et al. | β | 2014 | β |
| Genetic influences on alcohol use across stages of development: GABRA2 and longitudinal trajectories of drunkenness from adolescence to young adulthood. | Dick DM et al. | β | 2014 | β |
| Genetics of alcohol dependence: a review of clinical studies. | Samochowiec J et al. | β | 2014 | β |
| Genetics of alcoholism. | Edenberg HJ et al. | β | 2014 | β |
| Heritability and molecular-genetic basis of resting EEG activity: a genome-wide association study. | Malone SM et al. | β | 2014 | β |
| How do we 'learn' addiction? Risk factors and mechanisms getting addicted to alcohol. | HΓ€gele C et al. | β | 2014 | β |
| Knowns and unknowns for psychophysiological endophenotypes: integration and response to commentaries. | Iacono WG et al. | β | 2014 | β |
| Neurotransmitters in alcoholism: A review of neurobiological and genetic studies. | Banerjee N | β | 2014 | β |
| Association between GABA(A) receptor subunit gene cluster and zolpidem-induced complex sleep behaviors in Han Chinese. | Tsai JH et al. | β | 2013 | β |
| Effect of homozygous deletions at 22q13.1 on alcohol dependence severity and cue-elicited BOLD response in the precuneus. | Liu J et al. | β | 2013 | β |
| GABA receptors, alcohol dependence and criminal behavior. | Terranova C et al. | β | 2013 | β |
| Genetically selected alcohol preferring rats to model human alcoholism. | Ciccocioppo R | β | 2013 | β |
| Genetics of alcohol dependence and social work research: do they mix? | Hesselbrock MN et al. | β | 2013 | β |
| GET73 increases rat extracellular hippocampal CA1 GABA levels through a possible involvement of local mGlu5 receptor. | Beggiato S et al. | β | 2013 | β |
| Stability of scores and correlations with drinking behaviors over 15 years for the Self-Report of the Effects of Alcohol Questionnaire. | Schuckit MA et al. | β | 2013 | β |
| Alcohol Dependence and Genes Encoding Ξ±2 and Ξ³1 GABAA Receptor Subunits: Insights from Humans and Mice. | Borghese CM et al. | β | 2012 | β |
| Amygdala 14-3-3ΞΆ as a novel modulator of escalating alcohol intake in mice. | Lesscher HM et al. | β | 2012 | β |
| ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior. | Chen XD et al. | β | 2012 | β |
| Effects of vigabatrin, an irreversible GABA transaminase inhibitor, on ethanol reinforcement and ethanol discriminative stimuli in mice. | Griffin WC et al. | β | 2012 | β |
| GABA-A receptor genes do not play a role in genetics of Lesch's typology in Caucasian subjects. | Grzywacz A et al. | β | 2012 | β |
| Genome-wide association study identifies 5q21 and 9p24.1 (KDM4C) loci associated with alcohol withdrawal symptoms. | Wang KS et al. | β | 2012 | β |
| Management of alcohol abuse. | Albanese AP | β | 2012 | β |
| SRD5A1 genotype frequency differences in women with mild versus severe premenstrual symptoms. | Adams M et al. | β | 2012 | β |
| Alcohol research: past, present, and future. | Gunzerath L et al. | β | 2011 | β |
| Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes. | Rudolph U et al. | β | 2011 | β |
| Binge alcohol drinking is associated with GABAA alpha2-regulated Toll-like receptor 4 (TLR4) expression in the central amygdala. | Liu J et al. | β | 2011 | β |
| Binge Drinking: In Search of its Molecular Target via the GABA(A) Receptor. | Yang AR et al. | β | 2011 | β |
| Pharmacogenomics of alcohol metabolism: implications for legal testing. | Lippi G et al. | β | 2011 | β |
| Self-Rating of the Effects of Alcohol (SRE): Predictive utility and reliability across interview and self-report administrations. | Ray LA et al. | β | 2011 | β |
| The investigation into CYP2E1 in relation to the level of response to alcohol through a combination of linkage and association analysis. | Webb A et al. | β | 2011 | β |
| A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models. | Ehlers CL et al. | β | 2010 | β |
| Brain electrophysiological endophenotypes for externalizing psychopathology: a multivariate approach. | Gilmore CS et al. | β | 2010 | β |
| Candidate genes for alcohol preference identified by expression profiling in alcohol-preferring and -nonpreferring reciprocal congenic rats. | Liang T et al. | β | 2010 | β |
| GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence. | Xuei X et al. | β | 2010 | β |
| Genetic and environmental risk factors for adolescent-onset substance use disorders. | Meyers JL et al. | β | 2010 | β |
| Genetic research: who is at risk for alcoholism. | Foroud T et al. | β | 2010 | β |
| Genome-wide association study of alcohol dependence implicates a region on chromosome 11. | Edenberg HJ et al. | β | 2010 | β |
| Pharmacogenetics of alcohol and alcohol dependence treatment. | Kranzler HR et al. | β | 2010 | β |
| Addiction genetics and pleiotropic effects of common haplotypes that make polygenic contributions to vulnerability to substance dependence. | Uhl GR et al. | β | 2009 | β |
| Alcohol-induced tolerance and physical dependence in mice with ethanol insensitive alpha1 GABA A receptors. | Werner DF et al. | β | 2009 | β |
| Altering the relative abundance of GABA A receptor subunits changes GABA- and ethanol-responses in Xenopus oocytes. | Hurley JH et al. | β | 2009 | β |
| Associations among GABRG1, level of response to alcohol, and drinking behaviors. | Ray LA et al. | β | 2009 | β |
| The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress. | Kumar S et al. | β | 2009 | β |
| Addiction Reviews. Preface. | Uhl GR | β | 2008 | β |
| Binge drinking, poor mental health, and adherence to treatment among California adults with asthma. | Haskard KB et al. | β | 2008 | β |
| Clinical implications of tolerance to alcohol in nondependent young drinkers. | Schuckit MA et al. | β | 2008 | β |
| "Higher order" addiction molecular genetics: convergent data from genome-wide association in humans and mice. | Uhl GR et al. | β | 2008 | β |
| How adaptation of the brain to alcohol leads to dependence: a pharmacological perspective. | Clapp P et al. | β | 2008 | β |
| Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects. | Uhl GR et al. | β | 2008 | β |
| Neuropharmacology of alcohol addiction. | Vengeliene V et al. | β | 2008 | β |
| The genetics of alcohol and other drug dependence. | Dick DM et al. | β | 2008 | β |
| The role of GABA(A) receptors in the development of alcoholism. | Enoch MA | β | 2008 | β |
| World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Substance Use and Related Disorders, Part 1: Alcoholism. | Soyka M et al. | β | 2008 | β |
| Alcohol as a toxic and disease-forming agent: Not just the liver and brain and not every drinker | Srirajaskanthan R et al. | β | 2007 | β |
| Genomewide suggestive linkage of opioid dependence to chromosome 14q. | Lachman HM et al. | β | 2007 | β |
| Glutamate receptor metabotropic 7 is cis-regulated in the mouse brain and modulates alcohol drinking. | Vadasz C et al. | β | 2007 | β |