Illicit psychoactive substance use, heavy use, abuse, and dependence in a US population-based sample of male twins.
paper
Cited
Public
Unavailable
- Authors
- Kendler, K S; Karkowski, L M; Neale, M C; Prescott, C A
- Year
- 2000
- Journal
- Archives of general psychiatry
- PMID
- 10711912
- DOI
- 10.1001/archpsyc.57.3.261
BACKGROUND: In order to develop informed approaches to prevention and treatment of illicit psychoactive substance use, abuse, and dependence, we need to understand the sources of individual differences in risk. METHODS: In personal interviews with 1198 male-male twin pairs (708 monozygotic and 490 dizygotic) ascertained from a population-based registry, we assessed lifetime use, heavy use, and abuse of and dependence on cannabis, sedatives, stimulants, cocaine, opiates, and hallucinogens. Twin resemblance was assessed by probandwise concordance, odds ratio, tetrachoric correlations, and biometrical model fitting. RESULTS: Twin resemblance for substance use, heavy use, abuse, and dependence was substantial, and consistently greater in monozygotic than in dizygotic twins. For any drug use and for cannabis and hallucinogen use, model fitting suggested that twin resemblance was due to both genetic and familial-environmental factors. Twin resemblance for sedative, stimulant, cocaine, and opiate use, however, was caused solely by genetic factors. With 2 exceptions (cocaine abuse and stimulant dependence), twin resemblance for heavy use, abuse, and dependence resulted from only genetic factors, with heritability of liability usually ranging from 60% to 80%. No consistent evidence was found for violations of the equal environment assumption. CONCLUSIONS: In accord with prior results in studies of women, the family environment plays a role in twin resemblance for some forms of substance use in men. However, twin resemblance for heavy use, abuse, and dependence in men is largely caused by genetic factors, and heritability estimates are high.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Associations of childhood adversity and substance use disorder polygenic scores with disorder severity and diagnostic criteria. | SooHoo JF et al. | β | 2025 | β |
| Bitter Sensing Protects <i>Drosophila</i> from Developing Experience-Dependent Cocaine Consumption Preference. | Philyaw TJ et al. | β | 2025 | β |
| Genetic and Epigenetic Approaches to Opioid Use Disorder. | Ranadeva ND et al. | β | 2025 | β |
| Measuring the Associations Between Brain Morphometry and Polygenic Risk Scores for Substance use Disorders in Drug-Naive Adolescents. | Kramer S et al. | β | 2025 | β |
| Sweet-liking and sugar supplementation as innovative components in substance use disorder treatment: A systematic review. | van Amsterdam J et al. | β | 2025 | β |
| The influence of dopamine receptor SNPs on substance use disorder in a Jordanian cohort. | Al-Sanabra O et al. | β | 2025 | β |
| Differential etiologic associations of heroin use and prescription opioid misuse with psychopathology. | Dash GF et al. | β | 2024 | β |
| Effect of MAOA rs1465108 polymorphism on susceptibility to substance/alcohol use disorder: a novel PCR-RFLP assay for the detection of MAOA rs1465108. | Kaya-AkyΓΌzlΓΌ D et al. | β | 2024 | β |
| Generalized genetic liability to substance use disorders. | Miller AP et al. | β | 2024 | β |
| Genetic Variants Linked to Opioid Addiction: A Genome-Wide Association Study. | Panday SK et al. | β | 2024 | β |
| Male and female behavioral variability and morphine response in C57BL/6J, DBA/2J, and their BXD progeny following chronic stress exposure. | Morel C et al. | β | 2024 | β |
| Media framings of the role of genomics in "addiction" in the United States from 2015 to 2019: Individualized risk, biomedical expertise, and the limits of destigmatization. | Hendy K | β | 2024 | β |
| Neuroscience in addiction research. | Valentino RJ et al. | β | 2024 | β |
| Opioid trail: Tracking contributions to opioid use disorder from host genetics to the gut microbiome. | Duffy EP et al. | β | 2024 | β |
| Sex and genetic background influence intravenous oxycodone self-administration in the hybrid rat diversity panel. | Duffy EP et al. | β | 2024 | β |
| Substance Use Disorder. | Swimmer KR et al. | β | 2024 | β |
| Annual Research Review: Prenatal opioid exposure - a two-generation approach to conceptualizing neurodevelopmental outcomes. | Conradt E et al. | β | 2023 | β |
| A novel tetra-primer ARMS-PCR for genotyping of the OPRM1 gene rs1799971 variant associated with opioid use disorders. | Wijekumar PJ et al. | β | 2023 | β |
| Big Five personality traits and illicit drug use: Specificity in trait-drug associations. | Dash GF et al. | β | 2023 | β |
| Neonatal opioid toxicity: opioid withdrawal (abstinence) syndrome with emphasis on pharmacogenomics and respiratory depression. | Baldo BA | β | 2023 | β |
| Parental Divorce and Trajectories of Alcohol Consumption in Men: A Genetically Informative Perspective. | Salvatore JE et al. | β | 2023 | β |
| Pleiotropic loci for cannabis use disorder severity in multi-ancestry high-risk populations. | Peng Q et al. | β | 2023 | β |
| Polygenic risk scores and the need for pharmacotherapy in neonatal abstinence syndrome. | Bibi S et al. | β | 2023 | β |
| Principal component regression analysis of familial psychiatric histories and suicide risk factors among adults with opioid use disorder. | Szlyk HS et al. | β | 2023 | β |
| Risk factors for the development of opioid use disorder after first opioid prescription: a Swedish national study. | Kendler KS et al. | β | 2023 | β |
| Specificity in genetic and environmental risk for prescription opioid misuse and heroin use. | Dash GF et al. | β | 2023 | β |
| Association between Polymorphism rs1799732 of <i>DRD2</i> Dopamine Receptor Gene and Personality Traits among Cannabis Dependency. | Chmielowiec J et al. | β | 2022 | β |
| Association of Polymorphism within the Putative miRNA Target Site in the 3'UTR Region of the <i>DRD2</i> Gene with Neuroticism in Patients with Substance Use Disorder. | BoroΕ A et al. | β | 2022 | β |
| Cocaine Use Disorder (CUD): Current Clinical Perspectives. | Schwartz EKC et al. | β | 2022 | β |
| Consensus paper of the WFSBP task force on cannabis, cannabinoids and psychosis. | D'Souza DC et al. | β | 2022 | β |
| Contributions of epigenetic inheritance to the predisposition of major psychiatric disorders: Theoretical framework, evidence, and implications. | Varela RB et al. | β | 2022 | β |
| Extreme phenotypic diversity in operant response to intravenous cocaine or saline infusion in the hybrid mouse diversity panel. | Bagley JR et al. | β | 2022 | β |
| Methylation quantitative locus rs3758653 in the DRD4 gene is associated with duration from first heroin exposure to addiction. | Zhang R et al. | β | 2022 | β |
| Molecular genetics of cocaine use disorders in humans. | FernΓ ndez-Castillo N et al. | β | 2022 | β |
| Patterns of Substance Use Disorders and Associated Co-occurring Psychiatric Morbidity among Patients Seen at the Psychiatric Unit of a Tertiary Health Center. | Obadeji A et al. | β | 2022 | β |
| Pleiotropic Loci for Cannabis Use Disorder Severity in Multi-Ancestry High-Risk Populations | Peng Q et al. | β | 2022 | β |
| Predicting the Onset of Opioid Use Disorder in the Swedish General Population. | Kendler KS et al. | β | 2022 | β |
| Treating equivalent cases differently: A comparative analysis of substance use disorder and type 2 diabetes in Norwegian treatment guidelines. | Moe FD et al. | β | 2022 | β |
| Zhx2 Is a Candidate Gene Underlying Oxymorphone Metabolite Brain Concentration Associated with State-Dependent Oxycodone Reward. | Beierle JA et al. | β | 2022 | β |
| Adolescent Stress Reduces Adult Morphine-Induced Behavioral Sensitization in C57BL/6J Mice. | Kamens HM et al. | β | 2021 | β |
| Association of PICK1 and BDNF variations with increased risk of methamphetamine dependence among Iranian population: a case-control study. | Tajbakhsh A et al. | β | 2021 | β |
| Clinical Neuroscience of Addiction: What Clinical Psychologists Need to Know and Why. | Ray LA et al. | β | 2021 | β |
| Exploring the Genetic Underpinnings of Aggression in <i>Drosophila melanogaster</i>. | Takemori T | β | 2021 | β |
| Genetics of substance use disorders: a review. | Deak JD et al. | β | 2021 | β |
| Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes. | Sherva R et al. | β | 2021 | β |
| Identification of a sex-stratified genetic algorithm for opioid addiction risk. | Bright D et al. | β | 2021 | β |
| Looking for Sunshine: Genetic Predisposition to Sun Seeking in 265,000 Individuals of European Ancestry. | Sanna M et al. | β | 2021 | β |
| Molecular genetics of substance use disorders: An umbrella review. | Lopez-Leon S et al. | β | 2021 | β |
| Placental DNA methylation profiles in opioid-exposed pregnancies and associations with the neonatal opioid withdrawal syndrome. | Radhakrishna U et al. | β | 2021 | β |
| Reduced cue-induced reinstatement of cocaine-seeking behavior in Plcb1β+/-βmice. | Cabana-DomΓnguez J et al. | β | 2021 | β |
| Shared Environmental Influences on Electronic Cigarette Use Among Adolescent and Young Adult Females. | Bares C et al. | β | 2021 | β |
| Typologies of illicit drug use in mid-adulthood: a quasi-longitudinal latent class analysis in a community-based sample of twins. | Dash GF et al. | β | 2021 | β |
| Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): II. Externalizing superspectrum. | Krueger RF et al. | β | 2021 | β |
| A genome-wide association study of cocaine use disorder accounting for phenotypic heterogeneity and geneβenvironment interaction | Sun J et al. | β | 2020 | β |
| Anxiety and Depression among Amphetamine-Type Stimulant Users: The Association with Religiosity and Religious Coping. | Tan CH et al. | β | 2020 | β |
| Characterization of genetically complex Collaborative Cross mouse strains that model divergent locomotor activating and reinforcing properties of cocaine. | Schoenrock SA et al. | β | 2020 | β |
| Cocaine'omics: Genome-wide and transcriptome-wide analyses provide biological insight into cocaine use and dependence. | Huggett SB et al. | β | 2020 | β |
| Convergent functional genomics of cocaine misuse in humans and animal models. | Forero DA et al. | β | 2020 | β |
| Marriage and reductions in men's alcohol, tobacco, and cannabis use. | Salvatore JE et al. | β | 2020 | β |
| Non-genetic factors that influence methamphetamine intake in a genetic model of differential methamphetamine consumption. | Stafford AM et al. | β | 2020 | β |
| Pharmacokinetic and pharmacodynamic considerations in developing a response to the opioid epidemic. | Balyan R et al. | β | 2020 | β |
| The Genetics of Externalizing Problems. | Barr PB et al. | β | 2020 | β |
| The Streetlight Effect: Reappraising the Study of Addiction in Light of the Findings of Genome-wide Association Studies. | Hall FS et al. | β | 2020 | β |
| Translational Molecular Approaches in Substance Abuse Research. | Fulton SL et al. | β | 2020 | β |
| A review of opioid addiction genetics. | Crist RC et al. | β | 2019 | β |
| Characterization of DSM-IV Opioid Dependence Among Individuals of European Ancestry. | Brick LA et al. | β | 2019 | β |
| Family Aggregation of Substance Use Disorders: Substance Specific, Nonspecific, and Intrafamilial Sources of Risk. | Farmer RF et al. | β | 2019 | β |
| Genetic and environmental risk factors in the non-medical use of over-the-counter or prescribed analgesics, and their relationship to major classes of licit and illicit substance use and misuse in a population-based sample of young adult twins. | Gillespie NA et al. | β | 2019 | β |
| Transgenerational influence of parental morphine exposure on pain perception, anxiety-like behavior and passive avoidance memory among male and female offspring of Wistar rats. | Ahmadian-Moghadam H et al. | β | 2019 | β |
| Who's your daddy? Behavioral and epigenetic consequences of paternal drug exposure. | Nieto SJ et al. | β | 2019 | β |
| A non-coding CRHR2 SNP rs255105, a cis-eQTL for a downstream lincRNA AC005154.6, is associated with heroin addiction. | Levran O et al. | β | 2018 | β |
| Environmental, genetic and epigenetic contributions to cocaine addiction. | Pierce RC et al. | β | 2018 | β |
| Neuroepigenetics and addiction. | Walker DM et al. | β | 2018 | β |
| Association between the Intron 8 VNTR Polymorphism of the DAT1 Gene and Crack Cocaine Addiction. | Stolf AR et al. | β | 2017 | β |
| Collaborative Phenotype Inference from Comorbid Substance Use Disorders and Genotypes. | Lu J et al. | β | 2017 | β |
| Contributions of Genes and Environment to Developmental Change in Alcohol Use. | Long EC et al. | β | 2017 | β |
| Genetic and Environmental Contributions to the Association Between Cannabis Use and Psychotic-Like Experiences in Young Adult Twins. | NesvΓ₯g R et al. | β | 2017 | β |
| Heritability of lifetime ecstasy use. | Verweij KJH et al. | β | 2017 | β |
| Sex Differences in Methamphetamine Use and Dependence in a Thai Treatment Center. | Rungnirundorn T et al. | β | 2017 | β |
| The Genomics of Neonatal Abstinence Syndrome. | Cole FS et al. | β | 2017 | β |
| A Highly Polymorphic Copy Number Variant in the NSF Gene is Associated with Cocaine Dependence. | Cabana-DomΓnguez J et al. | β | 2016 | β |
| A Primer on the Genetics of Comorbid Eating Disorders and Substance Use Disorders. | Munn-Chernoff MA et al. | β | 2016 | β |
| Benzodiazepine use, misuse, and abuse: A review. | Schmitz A | β | 2016 | β |
| Cannabinoids: Medical implications. | Schrot RJ et al. | β | 2016 | β |
| Characterizing substance use and mental health profiles of cigar, blunt, and non-blunt marijuana users from the National Survey of Drug Use and Health. | Cohn A et al. | β | 2016 | β |
| Cross-generational transmission from drug abuse in parents to attention-deficit/hyperactivity disorder in children. | Kendler KS et al. | β | 2016 | β |
| Current evolutionary adaptiveness of psychiatric disorders: Fertility rates, parent-child relationship quality, and psychiatric disorders across the lifespan. | Jacobson NC | β | 2016 | β |
| Gene-environment interactions in a rat model of depression. Maternal separation affects neurotensin in selected brain regions. | Ellenbroek BA et al. | β | 2016 | β |
| Glutamatergic and GABAergic susceptibility loci for heroin and cocaine addiction in subjects of African and European ancestry. | Levran O et al. | β | 2016 | β |
| Heritability of high sugar consumption through drinks and the genetic correlation with substance use. | Treur JL et al. | β | 2016 | β |
| Neonatal abstinence syndrome: Pharmacologic strategies for the mother and infant. | Kraft WK et al. | β | 2016 | β |
| The Genetic and Environmental Association Between Parental Monitoring and Risk of Cannabis, Stimulants, and Cocaine Initiation in a Sample of Male Twins: Does Parenting Matter? | Olivares EL et al. | β | 2016 | β |
| The rearing environment and risk for drug abuse: a Swedish national high-risk adopted and not adopted co-sibling control study. | Kendler KS et al. | β | 2016 | β |
| Amphetamine self-administration and dopamine function: assessment of geneβΓβenvironment interactions in Lewis and Fischer 344 rats. | Meyer AC et al. | β | 2015 | β |
| A population-based Swedish Twin and Sibling Study of cannabis, stimulant and sedative abuse in men. | Kendler KS et al. | β | 2015 | β |
| A review of pharmacogenetic studies of substance-related disorders. | Jones JD et al. | β | 2015 | β |
| Association of substance dependence phenotypes in the COGA sample. | Wetherill L et al. | β | 2015 | β |
| Attention-deficit/hyperactivity disorder and risk for drug use disorder: a population-based follow-up and co-relative study. | Sundquist J et al. | β | 2015 | β |
| Corticosteroid receptor genes and childhood neglect influence susceptibility to crack/cocaine addiction and response to detoxification treatment. | Rovaris DL et al. | β | 2015 | β |
| Endocannabinoid signalling in reward and addiction. | Parsons LH et al. | β | 2015 | β |
| Environmental clustering of drug abuse in households and communities: multi-level modeling of a national Swedish sample. | Kendler KS et al. | β | 2015 | β |
| Family history density predicts long term substance use outcomes in an adolescent treatment sample. | Khoddam R et al. | β | 2015 | β |
| Opioids in pregnancy and neonatal abstinence syndrome. | Stover MW et al. | β | 2015 | β |
| Overlapping dopaminergic pathway genetic susceptibility to heroin and cocaine addictions in African Americans. | Levran O et al. | β | 2015 | β |
| Phenotypic heterogeneity in study populations may significantly confound the results of genetic association studies on alcohol dependence. | Ali MA et al. | β | 2015 | β |
| The association between cannabis abuse and subsequent schizophrenia: a Swedish national co-relative control study. | Giordano GN et al. | β | 2015 | β |
| The association between speed of transition from initiation to subsequent use of cannabis and later problematic cannabis use, abuse and dependence. | Hines LA et al. | β | 2015 | β |
| The causes of parent-offspring transmission of drug abuse: a Swedish population-based study. | Kendler KS et al. | β | 2015 | β |
| The pharmacogenetics of alcohol use disorder. | Jones JD et al. | β | 2015 | β |
| Transcriptomic and genetic studies identify NFAT5 as a candidate gene for cocaine dependence. | FernΓ ndez-Castillo N et al. | β | 2015 | β |
| Clinical features of drug abuse that reflect genetic risk. | Kendler KS et al. | β | 2014 | β |
| Community, siblings, heritability and the risk for drug abuse. | Hopfer C | β | 2014 | β |
| Environmental influences on familial resemblance for drug abuse in first-cousin pairs: a Swedish national study. | Kendler KS et al. | β | 2014 | β |
| Epigenetic variation in the mu-opioid receptor gene in infants with neonatal abstinence syndrome. | Wachman EM et al. | β | 2014 | β |
| Genetic and environmental risk factors for illicit substance use and use disorders: Joint analysis of self and co-twin ratings. | Ystrom E et al. | β | 2014 | β |
| Genetic and family and community environmental effects on drug abuse in adolescence: a Swedish national twin and sibling study. | Kendler KS et al. | β | 2014 | β |
| Genetics of Opioid Dependence: A Review of the Genetic Contribution to Opioid Dependence. | Mistry CJ et al. | β | 2014 | β |
| Genetic variation in personality traits explains genetic overlap between borderline personality features and substance use disorders. | Few LR et al. | β | 2014 | β |
| Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene. | Gelernter J et al. | β | 2014 | β |
| Moderators of the association between peer and target adolescent substance use. | Marschall-LΓ©vesque S et al. | β | 2014 | β |
| The causal nature of the association between neighborhood deprivation and drug abuse: a prospective national Swedish co-relative control study. | Kendler KS et al. | β | 2014 | β |
| The dopamine receptor D2 (DRD2) SNP rs1076560 is associated with opioid addiction. | Clarke TK et al. | β | 2014 | β |
| The role of the habenula in drug addiction. | Velasquez KM et al. | β | 2014 | β |
| Trajectory of adolescent cannabis use on addiction vulnerability. | Hurd YL et al. | β | 2014 | β |
| A family history of substance dependence obscures the group differences in brain function associated with HIV-1 and ART. | Bauer LO | β | 2013 | β |
| ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure. | Nelson EC et al. | β | 2013 | β |
| Are addictions diseases or choices? | Leyton M | β | 2013 | β |
| Association of OPRM1 and COMT single-nucleotide polymorphisms with hospital length of stay and treatment of neonatal abstinence syndrome. | Wachman EM et al. | β | 2013 | β |
| Association study of 37 genes related to serotonin and dopamine neurotransmission and neurotrophic factors in cocaine dependence. | FernΓ ndez-Castillo N et al. | β | 2013 | β |
| Butyrylcholinesterase genetic variants: association with cocaine dependence and related phenotypes. | NegrΓ£o AB et al. | β | 2013 | β |
| Case-control association analysis of polymorphisms in the Ξ΄-opioid receptor, OPRD1, with cocaine and opioid addicted populations. | Crist RC et al. | β | 2013 | β |
| Case-control association study of WLS variants in opioid and cocaine addicted populations. | Crist RC et al. | β | 2013 | β |
| Decision making in the pathway from genes to psychiatric and substance use disorders. | Kendler KS | β | 2013 | β |
| Evidence for a genetic component for substance dependence in Native Americans. | Ehlers CL et al. | β | 2013 | β |
| Four factors for the initiation of substance use by young adulthood: a 10-year follow-up twin and sibling study of marital conflict, monitoring, siblings, and peers. | Neiderhiser JM et al. | β | 2013 | β |
| Further evidence for association of polymorphisms in the CNR1 gene with cocaine addiction: confirmation in an independent sample and meta-analysis. | Clarke TK et al. | β | 2013 | β |
| Genetic and environmental predictors of latent trajectories of alcohol use from adolescence to adulthood: a male twin study. | Wichers M et al. | β | 2013 | β |
| Implications of genome wide association studies for addiction: are our a priori assumptions all wrong? | Hall FS et al. | β | 2013 | β |
| Neuroplasticity, axonal guidance and micro-RNA genes are associated with morphine self-administration behavior. | Tapocik JD et al. | β | 2013 | β |
| Positive association between--1021TT genotype of dopamine beta hydroxylase gene and progressive behavior of injection heroin users. | Xie X et al. | β | 2013 | β |
| The moderating effect of parental illicit substance use disorders on the relation between adolescent depression and subsequent illicit substance use disorders. | Gorka SM et al. | β | 2013 | β |
| Within-family environmental transmission of drug abuse: a Swedish national study. | Kendler KS et al. | β | 2013 | β |
| Analysis of dopamine D2 receptor (DRD2) gene polymorphisms in cannabinoid addicts. | Nacak M et al. | β | 2012 | β |
| Are the symptoms of cannabis use disorder best accounted for by dimensional, categorical, or factor mixture models? A comparison of male and female young adults. | Gillespie NA et al. | β | 2012 | β |
| Association of the Neuronal Cell Adhesion Molecule (NrCAM) Gene Variants with Personality Traits and Addictive Symptoms in Methamphetamine Use Disorder. | Yoo BK et al. | β | 2012 | β |
| Association study of the Ξ²-arrestin 2 gene (ARRB2) with opioid and cocaine dependence in a European-American population. | Ambrose-Lanci LM et al. | β | 2012 | β |
| Candidate pathway association study in cocaine dependence: the control of neurotransmitter release. | FernΓ ndez-Castillo N et al. | β | 2012 | β |
| Cannabis-dependence risk relates to synergism between neuroticism and proenkephalin SNPs associated with amygdala gene expression: case-control study. | Jutras-Aswad D et al. | β | 2012 | β |
| [Cannabis: Use and dependence]. | Dervaux A et al. | β | 2012 | β |
| Common liability to addiction and "gateway hypothesis": theoretical, empirical and evolutionary perspective. | Vanyukov MM et al. | β | 2012 | β |
| Epidemiology of substance use disorders. | Merikangas KR et al. | β | 2012 | β |
| Gambling, disordered gambling and their association with major depression and substance use: a web-based cohort and twin-sibling study. | Blanco C et al. | β | 2012 | β |
| Genetic and familial environmental influences on the risk for drug abuse: a national Swedish adoption study. | Kendler KS et al. | β | 2012 | β |
| Genetic factors modulating the response to stimulant drugs in humans. | Hart AB et al. | β | 2012 | β |
| Genome-environmental risk assessment of cocaine dependence. | Wei C et al. | β | 2012 | β |
| Mouse models for studying genetic influences on factors determining smoking cessation success in humans. | Hall FS et al. | β | 2012 | β |
| Neuronal calcium sensor-1 and cocaine addiction: a genetic association study in African-Americans and European Americans. | Multani PK et al. | β | 2012 | β |
| Positive and negative effects of alcohol and nicotine and their interactions: a mechanistic review. | Hurley LL et al. | β | 2012 | β |
| Shared environmental contributions to substance use. | Baker JH et al. | β | 2012 | β |
| The aggregate effect of dopamine genes on dependence symptoms among cocaine users: cross-validation of a candidate system scoring approach. | Derringer J et al. | β | 2012 | β |
| The genetic basis of addictive disorders. | Ducci F et al. | β | 2012 | β |
| The genetics of addiction-a translational perspective. | Agrawal A et al. | β | 2012 | β |
| Two-part random effects growth modeling to identify risks associated with alcohol and cannabis initiation, initial average use and changes in drug consumption in a sample of adult, male twins. | Gillespie NA et al. | β | 2012 | β |
| Alcohol dependence in men: reliability and heritability. | Ystrom E et al. | β | 2011 | β |
| A pilot study of life events and mood disorders: self-report survey in chinese heroin-dependent individuals. | Liao Y et al. | β | 2011 | β |
| Cannabis use and age at onset of psychosis: further evidence of interaction with COMT Val158Met polymorphism. | Estrada G et al. | β | 2011 | β |
| Cannabis use and development of externalizing and internalizing behaviour problems in early adolescence: A TRAILS study. | Griffith-Lendering MF et al. | β | 2011 | β |
| Considerations of elder sibling closeness in predicting younger sibling substance use: social learning versus social bonding explanations. | Samek DR et al. | β | 2011 | β |
| Genome-wide association study in bipolar patients stratified by co-morbidity. | Kerner B et al. | β | 2011 | β |
| Genomic regions identified by overlapping clusters of nominally-positive SNPs from genome-wide studies of alcohol and illegal substance dependence. | Johnson C et al. | β | 2011 | β |
| Predicting alcohol consumption in adolescence from alcohol-specific and general externalizing genetic risk factors, key environmental exposures and their interaction. | Kendler KS et al. | β | 2011 | β |
| Preliminary evidence for associations of CHRM2 with substance use and disinhibition in adolescence. | Hendershot CS et al. | β | 2011 | β |
| Psychiatric 'diseases' versus behavioral disorders and degree of genetic influence. | Bienvenu OJ et al. | β | 2011 | β |
| Psychometric modeling of cannabis initiation and use and the symptoms of cannabis abuse, dependence and withdrawal in a sample of male and female twins. | Gillespie NA et al. | β | 2011 | β |
| "Replicated" genome wide association for dependence on illegal substances: genomic regions identified by overlapping clusters of nominally positive SNPs. | Drgon T et al. | β | 2011 | β |
| Salvia divinorum use and phenomenology: results from an online survey. | Sumnall HR et al. | β | 2011 | β |
| Sex differences and developmental stability in genetic and environmental influences on psychoactive substance consumption from early adolescence to young adulthood. | Baker JH et al. | β | 2011 | β |
| A cotwin-control analysis of drug use and abuse/dependence risk associated with early-onset cannabis use. | Grant JD et al. | β | 2010 | β |
| Are there guidelines for the responsible prescription of benzodiazepines? | el-Guebaly N et al. | β | 2010 | β |
| Association analysis between polymorphisms in the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes with cocaine dependence. | Lohoff FW et al. | β | 2010 | β |
| Cannabis dependence in the San Francisco Family Study: age of onset of use, DSM-IV symptoms, withdrawal, and heritability. | Ehlers CL et al. | β | 2010 | β |
| Cocaine abuse versus cocaine dependence: cocaine self-administration and pharmacodynamic response in the human laboratory. | Walsh SL et al. | β | 2010 | β |
| Common genetic contributions to alcohol and cannabis use and dependence symptomatology. | Sartor CE et al. | β | 2010 | β |
| Could the inter-individual variability in cocaine-induced psychotic effects influence the development of cocaine addiction? Towards a new pharmacogenetic approach to addictions. | Brousse G et al. | β | 2010 | β |
| Delineating the psychic structure of substance abuse and addictions: should anxiety, mood and impulse-control dysregulation be included? | Pani PP et al. | β | 2010 | β |
| EEG spectral phenotypes: heritability and association with marijuana and alcohol dependence in an American Indian community study. | Ehlers CL et al. | β | 2010 | β |
| Genetically informative research on adolescent substance use: methods, findings, and challenges. | Lynskey MT et al. | β | 2010 | β |
| Genetic and environmental influences on cannabis use initiation and problematic use: a meta-analysis of twin studies. | Verweij KJ et al. | β | 2010 | β |
| Genetics of drug dependence. | Gelernter J et al. | β | 2010 | β |
| Genome wide association for addiction: replicated results and comparisons of two analytic approaches. | Drgon T et al. | β | 2010 | β |
| Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. | Uhl GR et al. | β | 2010 | β |
| Heritability of cannabis initiation in Dutch adult twins. | Vink JM et al. | β | 2010 | β |
| Linkage analyses of cannabis dependence, craving, and withdrawal in the San Francisco family study. | Ehlers CL et al. | β | 2010 | β |
| Neural markers of genetic vulnerability to drug addiction. | MΓΌller DJ et al. | β | 2010 | β |
| Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment. | Yuferov V et al. | β | 2010 | β |
| Tobacco, cannabis, and other illicit drug use among Finnish adolescent twins: causal relationship or correlated liabilities? | Huizink AC et al. | β | 2010 | β |
| Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes. | Sherva R et al. | β | 2010 | β |
| Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence. | Lohoff FW et al. | β | 2009 | β |
| Association study between the PIK4CA gene and methamphetamine use disorder in a Japanese population. | Kanahara N et al. | β | 2009 | β |
| Candidate genes for cannabis use disorders: findings, challenges and directions. | Agrawal A et al. | β | 2009 | β |
| Genome-wide association for nicotine dependence and smoking cessation success in NIH research volunteers. | Drgon T et al. | β | 2009 | β |
| Genome-wide association for smoking cessation success: participants in a trial with adjunctive denicotinized cigarettes. | Drgon T et al. | β | 2009 | β |
| Heritability and a genome-wide linkage analysis of a Type II/B cluster construct for cannabis dependence in an American Indian community. | Ehlers CL et al. | β | 2009 | β |
| Modeling the genetic and environmental association between peer group deviance and cannabis use in male twins. | Gillespie NA et al. | β | 2009 | β |
| Pathways to cannabis abuse: a multi-stage model from cannabis availability, cannabis initiation and progression to abuse. | Gillespie NA et al. | β | 2009 | β |
| Role of endocannabinoid signaling in anxiety and depression. | Patel S et al. | β | 2009 | β |
| Addiction science and its genetics. | Ball D | β | 2008 | β |
| Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence. | Lohoff FW et al. | β | 2008 | β |
| Association study between casein kinase 1 epsilon gene and methamphetamine dependence. | Kotaka T et al. | β | 2008 | β |
| Association study between polymorphisms in glutathione-related genes and methamphetamine use disorder in a Japanese population. | Hashimoto T et al. | β | 2008 | β |
| Dopamine-beta hydroxylase polymorphism and cocaine addiction. | Guindalini C et al. | β | 2008 | β |
| Drug use and dependence in cocaine dependent subjects, community-based individuals, and their siblings. | Bierut LJ et al. | β | 2008 | β |
| Forum: Decriminalization of cannabis. | van den Brink W | β | 2008 | β |
| Genetic and environmental contributions to nicotine, alcohol and cannabis dependence in male twins. | Xian H et al. | β | 2008 | β |
| Genetic and environmental influences on alcohol, caffeine, cannabis, and nicotine use from early adolescence to middle adulthood. | Kendler KS et al. | β | 2008 | β |
| Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence. | Lohoff FW et al. | β | 2008 | β |
| Genome wide association for substance dependence: convergent results from epidemiologic and research volunteer samples. | Johnson C et al. | β | 2008 | β |
| Genome-wide linkage analysis of heroin dependence in Han Chinese: results from Wave Two of a multi-stage study. | Glatt SJ et al. | β | 2008 | β |
| Marijuana withdrawal and craving: influence of the cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH) genes. | Haughey HM et al. | β | 2008 | β |
| Measured environmental contributions to cannabis abuse/dependence in an offspring of twins design. | Scherrer JF et al. | β | 2008 | β |
| P3 components of the event-related potential and marijuana dependence in Southwest California Indians. | Ehlers CL et al. | β | 2008 | β |
| Pathways from earlier marijuana use in the familial and non-familial environments to self-marijuana use in the fourth decade of life. | Brook JS et al. | β | 2008 | β |
| Psychopathology in offspring from multiplex alcohol dependence families with and without parental alcohol dependence: a prospective study during childhood and adolescence. | Hill SY et al. | β | 2008 | β |
| A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: evidence for linkage on chromosomes 3 and 9. | Hopfer CJ et al. | β | 2007 | β |
| Age of first marijuana use and the occurrence of marijuana use disorders in Southwest California Indians. | Ehlers CL et al. | β | 2007 | β |
| A longitudinal study of personality and major depression in a population-based sample of male twins. | Fanous AH et al. | β | 2007 | β |
| Association analysis of GRK3 gene promoter variants in cocaine abuse. | Guindalini C et al. | β | 2007 | β |
| Can comparison of MZ- and DZ-twin concordance rates be used invariably to estimate heritability? | Tishler PV et al. | β | 2007 | β |
| Creating a social world: a developmental twin study of peer-group deviance. | Kendler KS et al. | β | 2007 | β |
| Differences in dopamine responsiveness to drugs of abuse in the nucleus accumbens shell and core of Lewis and Fischer 344 rats. | Cadoni C et al. | β | 2007 | β |
| Evaluation of OPRM1 variants in heroin dependence by family-based association testing and meta-analysis. | Glatt SJ et al. | β | 2007 | β |
| Factor and item-response analysis DSM-IV criteria for abuse of and dependence on cannabis, cocaine, hallucinogens, sedatives, stimulants and opioids. | Gillespie NA et al. | β | 2007 | β |
| Genomic screen for substance dependence and body mass index in southwest California Indians. | Ehlers CL et al. | β | 2007 | β |
| Heritability of illicit drug use and transition to dependence in Southwest California Indians. | Ehlers CL et al. | β | 2007 | β |
| Longitudinal modeling of genetic and environmental influences on self-reported availability of psychoactive substances: alcohol, cigarettes, marijuana, cocaine and stimulants. | Gillespie NA et al. | β | 2007 | β |
| Variation in a bicarbonate co-transporter gene family member SLC4A7 is associated with propensity to addictions: a study using fine-mapping and three samples. | Ishiguro H et al. | β | 2007 | β |
| Age at first intoxication and alcohol use disorders in Southwest California Indians. | Ehlers CL et al. | β | 2006 | β |
| Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence. | Dahl JP et al. | β | 2006 | β |
| Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. | Agrawal A et al. | β | 2006 | β |
| Assortative mating for cigarette smoking and for alcohol consumption in female Australian twins and their spouses. | Agrawal A et al. | β | 2006 | β |
| A test of the equal environment assumption (EEA) in multivariate twin studies. | Derks EM et al. | β | 2006 | β |
| Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescents. | Hopfer CJ et al. | β | 2006 | β |
| Duration of cannabis use--a novel phenotype? | Lynskey MT et al. | β | 2006 | β |
| Genetic variant of prodynorphin gene is risk factor for methamphetamine dependence. | Nomura A et al. | β | 2006 | β |
| Genome-wide linkage analysis of heroin dependence in Han Chinese: results from wave one of a multi-stage study. | Glatt SJ et al. | β | 2006 | β |
| Genomic screen for loci associated with tobacco usage in Mission Indians. | Ehlers CL et al. | β | 2006 | β |
| Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia. | Malison RT et al. | β | 2006 | β |
| Illicit psychoactive substance use, abuse and dependence in a population-based sample of Norwegian twins. | Kendler KS et al. | β | 2006 | β |
| Is there heterogeneity among syndromes of substance use disorder for illicit drugs? | Beseler C et al. | β | 2006 | β |
| Linkage disequilibrium, haplotype and association studies of a chromosome 4 GABA receptor gene cluster: candidate gene variants for addictions. | Drgon T et al. | β | 2006 | β |
| Linking substance use and problem behavior across three generations. | Bailey JA et al. | β | 2006 | β |
| Neural mechanisms of addiction: the role of reward-related learning and memory. | Hyman SE et al. | β | 2006 | β |
| No association between polymorphisms in the prostate apoptosis factor-4 gene and cocaine dependence. | Weller AE et al. | β | 2006 | β |
| NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice. | Ishiguro H et al. | β | 2006 | β |
| Reflections on the relationship between psychiatric genetics and psychiatric nosology. | Kendler KS | β | 2006 | β |
| Symbiotic relationship of pharmacogenetics and drugs of abuse. | Rutter JL | β | 2006 | β |
| The genetic epidemiology of cannabis use, abuse and dependence. | Agrawal A et al. | β | 2006 | β |
| Toward a comprehensive developmental model for major depression in men. | Kendler KS et al. | β | 2006 | β |
| A functional glutathione S-transferase P1 gene polymorphism is associated with methamphetamine-induced psychosis in Japanese population. | Hashimoto T et al. | β | 2005 | β |
| A genome scan of neuroticism in nicotine dependent smokers. | Neale BM et al. | β | 2005 | β |
| Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population. | Dahl JP et al. | β | 2005 | β |
| Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence. | Dahl JP et al. | β | 2005 | β |
| Contrasting predictors of readiness for substance abuse treatment in adults and adolescents: a latent variable analysis of DATOS and DATOS-A participants. | Handelsman L et al. | β | 2005 | β |
| Genetic determinants of addiction to opioids and cocaine. | Saxon AJ et al. | β | 2005 | β |
| Haplotype association between GABAA receptor gamma2 subunit gene (GABRG2) and methamphetamine use disorder. | Nishiyama T et al. | β | 2005 | β |
| Illicit drug use and abuse/dependence: modeling of two-stage variables using the CCC approach. | Agrawal A et al. | β | 2005 | β |
| Individual differences in drug dependence in rats: the role of genetic factors and life events. | Ellenbroek BA et al. | β | 2005 | β |
| The differential heritability of regular tobacco use based on method of administration. | Schmitt JE et al. | β | 2005 | β |
| The differential impact of risk factors on illicit drug involvement in females. | Agrawal A et al. | β | 2005 | β |
| The genetics of addictions: uncovering the genes. | Goldman D et al. | β | 2005 | β |
| The X-box binding protein 1 (XBP1) gene is not associated with methamphetamine dependence. | Morita Y et al. | β | 2005 | β |
| Adverse effects of cannabis on health: an update of the literature since 1996. | Kalant H | β | 2004 | β |
| Cannabis and other illicit drugs: comorbid use and abuse/dependence in males and females. | Agrawal A et al. | β | 2004 | β |
| Forms of cannabis and cocaine: a twin study. | Agrawal A et al. | β | 2004 | β |
| Gene-environment interplay in alcoholism and other substance abuse disorders: expressions of heritability and factors influencing vulnerability. | Palomo T et al. | β | 2004 | β |
| Genetics and drug use as a complex phenotype. | Lessov CN et al. | β | 2004 | β |
| Identifying shared environmental contributions to early substance use: the respective roles of peers and parents. | Walden B et al. | β | 2004 | β |
| Is the party over? Cannabis and juvenile psychiatric disorder: the past 10 years. | Rey JM et al. | β | 2004 | β |
| No association found between the type 1 sigma receptor gene polymorphisms and methamphetamine abuse in the Japanese population: a collaborative study by the Japanese Genetics Initiative for Drug Abuse. | Inada T et al. | β | 2004 | β |
| No association is found between the candidate genes of t-PA/plasminogen system and Japanese methamphetamine-related disorder: a collaborative study by the Japanese Genetics Initiative for Drug Abuse. | Iwata N et al. | β | 2004 | β |
| Abuse and violence history of men and women in treatment for methamphetamine dependence. | Cohen JB et al. | β | 2003 | β |
| A genome-wide search for quantitative trait loci influencing substance dependence vulnerability in adolescence. | Stallings MC et al. | β | 2003 | β |
| Escalation of drug use in early-onset cannabis users vs co-twin controls. | Lynskey MT et al. | β | 2003 | β |
| Exploring the association between cannabis use and depression. | Degenhardt L et al. | β | 2003 | β |
| Family transmission of marijuana use, abuse, and dependence. | Hopfer CJ et al. | β | 2003 | β |
| Genetic and environmental risk factors in adolescent substance use. | Silberg J et al. | β | 2003 | β |
| Genetic variation in the psychomotor stimulant properties of cocaine in Mus musculus. | Downing C et al. | β | 2003 | β |
| Impaired emotional facial expression recognition in alcoholics, opiate dependence subjects, methadone maintained subjects and mixed alcohol-opiate antecedents subjects compared with normal controls. | Kornreich C et al. | β | 2003 | β |
| Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependence. | Franke P et al. | β | 2003 | β |
| Maternal correlates of toddler insecure and dependent behavior. | Brook JS et al. | β | 2003 | β |
| Nine- or fewer repeat alleles in VNTR polymorphism of the dopamine transporter gene is a strong risk factor for prolonged methamphetamine psychosis. | Ujike H et al. | β | 2003 | β |
| Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins. | Kendler KS et al. | β | 2003 | β |
| An alternative model is feasible, but the gateway hypothesis has not been invalidated: comments on Morral et al. | Lynskey M | β | 2002 | β |
| Gene-environment interaction effects on behavioral variation and risk of complex disorders: the example of alcoholism and other psychiatric disorders. | Heath AC et al. | β | 2002 | β |
| Reassessing the marijuana gateway effect. | Morral AR et al. | β | 2002 | β |
| Sedative use and misuse in the United States. | Goodwin RD et al. | β | 2002 | β |
| Sex differences in shared genetic and environmental influences between conduct disorder symptoms and marijuana use in adolescents. | Miles DR et al. | β | 2002 | β |
| The prevention of gambling problems in youth: a conceptual framework. | Dickson LM et al. | β | 2002 | β |
| Addiction and the brain: the neurobiology of compulsion and its persistence. | Hyman SE et al. | β | 2001 | β |
| An integrative approach for studying the etiology of alcoholism and other addictions. | Jacob T et al. | β | 2001 | β |
| A twin study on sensation seeking, risk taking behavior and marijuana use. | Miles DR et al. | β | 2001 | β |
| Nonreplication of association between mu-opioid-receptor gene (OPRM1) A118G polymorphism and substance dependence. | Franke P et al. | β | 2001 | β |
| Genes and addiction. | Nestler EJ | β | 2000 | β |
| Implications of genetic epidemiology for the prevention of substance use disorders. | Merikangas KR et al. | β | 2000 | β |
| Pharmacogenomics and addiction to opiates. | Lichtermann D et al. | β | 2000 | β |
| Reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors. | Blum K et al. | β | 2000 | β |