Genetic factors modulating the response to stimulant drugs in humans.

paper Cited Public

Authors: Hart, Amy B; de Wit, Harriet; Palmer, Abraham A
Year: 2012
Journal: Current topics in behavioral neurosciences
PMID: 22261702
DOI: 10.1007/7854_2011_187
PMCID: PMC3388157

#	Section	Preview
0	1 Introduction	A growing body of evidence suggests that genetic variation underlies inter-individual variability in…
1	1 Introduction	In this review we will focus on five prototypic stimulant drugs that have been studied most…
2	1 Introduction	We will focus on two types of genetic studies in this review, twin and association studies. Twin…
3	1 Introduction	of genetic differences. In these studies, polymorphisms within or near the candidate gene are tested…
4	1 Introduction	In all of the studies discussed: twin, candidate gene association, and genome-wide association, we…
5	1 Introduction	We will attempt to synthesize genetic studies of acute, sub-chronic, and chronic administration of…
6	2 Twin Studies of Stimulant Drug Phenotypes	Two early twin studies provide strong evidence for the heritability of acute responses to stimulant…
7	2 Twin Studies of Stimulant Drug Phenotypes	More recently, twin studies have examined the heritability of lifetime stimulant use, dependence,…
8	3 Association Studies	Genetic determinants of response to acute, sub-chronic, and chronic administration of stimulant…
9	3 Association Studies	several times a day in a therapeutic context, and the outcome measure is usually therapeutic…
10	3 Association Studies	Sub-chronic (i.e.,< 8 weeks) or chronic (>8 weeks) stimulant responses have been measured in…
11	3 Association Studies	Studies of responses to stimulant drugs have focused on a small number of candidate genes that have…
12	4 Monoamine Transporters — SLC6A3	The dopamine transporter (SLC6A3; DAT1; DAT) is a direct target of stimulant drugs and thus a…
13	4 Monoamine Transporters — SLC6A3	In analyses examining associations of amphetamine response with the SLC6A3 3′-UTR VNTR, we found…
14	4 Monoamine Transporters — SLC6A3	The 3′-UTR VNTR polymorphism has also been studied in relation to acute responses to…
15	4 Monoamine Transporters — SLC6A3	SLC6A3 has also been the analyzed for its role in modulating therapeutic responses to sub-chronic (8…
16	4 Monoamine Transporters — SLC6A3	The association between the 3′-UTR VNTR and response to sub-chronic methylphenidate has also been…
17	4 Monoamine Transporters — SLC6A3	Although the results discussed above suggest that the 10-repeat allele may be associated with poor…
18	4 Monoamine Transporters — SLC6A3	Stein et al. (2005), children with the 9/10 and 10/10 genotypes showed significant improvement in…
19	4 Monoamine Transporters — SLC6A3	The dopamine transporter has also been studied in relation to stimulant drug abuse. In these…

Citation	PMID	DOI	Status
Allen, N et al., Nat Genet, 2008, Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database	18583979	10.1038/ng.171	Cited
Andersen, S et al., Pharmacogenomics, 2009, Variation in the COMT gene: implications for pain perception and pain treatment	19374521	10.2217/pgs.09.13	Cited
Aoyama, N et al., Alcohol Clin Exp Res, 2006, Genetic Factors Modulating the Response to Stimulant Drugs in Humans Association between gene polymorphisms of SLC22A3 and methamphetamine use disorder	17010131	10.1111/j.1530-0277.2006.00215.x	Cited
Asherson, P et al., Am J Psychiatry, 2007, Confirmation that a specific haplotype of the dopamine transporter gene is associated with combined-type ADHD	17403983	10.1176/ajp.2007.164.4.674	Cited
Banaschewski, T et al., Eur child adolescent psychiatry, 2010, Molecular genetics of attention-deficit/hyperactivity disorder: an overview	20145962	10.1007/s00787-010-0090-z	Cited
Bellgrove, MA et al., Neuropsychopharmacology, 2005, Association between dopamine transporter (DAT1) genotype, left-sided inattention, and an enhanced response to methylphenidate in attention-deficit hyperactivity disorder	16123773	10.1038/sj.npp.1300839	Cited
Bergen, A et al., Mol Psychiatry, 1997, Mu opioid receptor gene variants: lack of association with alcohol dependence	9399694	10.1038/sj.mp.4000331	Cited
Bloch, M et al., Am J Med Genet Part B Neuropsychiatr Genet, 2008, Association of the serotonin transporter polymorphism and obsessive-compulsive disorder: systematic review	18186076	10.1002/ajmg.b.30699	Cited
Bond, C et al., Proc Natl Acad Sci U S A, 1998, Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity: possible implications for opiate addiction	9689128	10.1073/pnas.95.16.9608	Cited
Brookes, K et al., Mol Psychiatry, 2006, The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes	16894395	10.1038/sj.mp.4001869	Cited
Brown, G et al., J Affect Disord, 2008, Depression and the serotonin transporter 5-HTTLPR polymorphism: a review and a hypothesis concerning gene-environment interaction	18534686	10.1016/j.jad.2008.04.009	Cited
Brown, WA et al., Psychopharmacology (Berl), 1978, Acute psychologic and neuroendocrine effects of dextroamphetamine and methylphenidate	98790	10.1007/BF00426906	Cited
Bryant, CD et al., Psychopharmacology (Berl), 2009, A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine	19050854	10.1007/s00213-008-1417-z	Cited
Cabeza, R et al., Curr Opin Neurol, 2000, Neural bases of learning and memory: functional neuroimaging evidence	10970058	10.1097/00019052-200008000-00008	Cited
Chen, C et al., Psychiatr Genet, Association analysis of dopamine D2-like receptor genes and methamphetamine abuse	15564898	10.1097/00041444-200412000-00011	Cited
Chen, J et al., Am J Human Genet, Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain	15457404	10.1086/425589	Cited
Cheon, K et al., Eur Neuropsychopharmacol, 2005, The homozygosity for 10-repeat allele at dopamine transporter gene and dopamine transporter density in Korean children with attention deficit hyperactivity disorder: relating to treatment response to methylphenidate	15572278	10.1016/j.euroneuro.2004.06.004	Cited
Cheon, K et al., Neuropsychopharmacology, 2006, Association of 4-repeat allele of the dopamine D4 receptor gene exon III polymorphism and response to methylphenidate treatment in Korean ADHD children	17077808	10.1038/sj.npp.1301244	Cited
Crabbe, J et al., Acta Genet Med Gemellol (Roma), 1983, Behavioral responses to amphetamines in identical twins	6685963	10.1017/s0001566000006425	Cited
Cropley, V et al., Biol Psychiatry, 2006, Molecular imaging of the dopaminergic system and its association with human cognitive function	16682268	10.1016/j.biopsych.2006.03.004	Cited
Cubells, J et al., Mol Psychiatry, 2000, A haplotype at the DBH locus, associated with low plasma dopamine β-hydroxylase activity, also associates with cocaine-induced paranoia	10673769	10.1038/sj.mp.4000657	Cited
da Silva, M et al., J Atten Disord, 2010, Lack of association between a 30UTR VNTR 776 polymorphism of dopamine transporter gene (SLC6A3) and ADHD in a Brazilian sample of 777 adult patients	20332413	10.1177/1087054710365989	Cited
Daly, J et al., Drug Alcohol Depend, 1998, Caffeine—an atypical drug of dependence	9716941	10.1016/s0376-8716(98)00077-5	Cited
David, S et al., Nicotine Tob Res, 2007, Bupropion efficacy for smoking cessation is influenced by the DRD2 Taq1A polymorphism: analysis of pooled data from two clinical trials	18058343	10.1080/14622200701705027	Cited
David, S et al., Pharmacogenomics, 2008, Genetic variation in the dopamine pathway and smoking cessation	18781857	10.2217/14622416.9.9.1307	Cited
de Wit, H et al., Behav Neurosci, 2000, Effects of d-amphetamine and ethanol on a measure of behavioral inhibition in humans	10959541	10.1037//0735-7044.114.4.830	Cited
de Wit, H et al., Drug Alcohol Depend, 1986, Individual differences in the reinforcing and subjective effects of amphetamine and diazepam	3698813	10.1016/0376-8716(86)90068-2	Cited
de Wit, H, Addict Bio, 2009, Impulsivity as a determinant and consequence of drug use: a review of underlying processes	18855805	10.1111/j.1369-1600.2008.00129.x	Cited
den Hoed, M et al., Diabetes, 2010, Genetic susceptibility to obesity and related traits in childhood and adolescence; influence of loci identified by genome-wide association studies	20724581	10.2337/db10-0370	Cited
Diagnostic and statistical manual of mental disorders, 1987	—	—	—
Dlugos, A et al., Biol Psychiatry, 2007, Norepinephrine transporter gene variation modulates acute response to D-amphetamine	17239355	10.1016/j.biopsych.2006.09.031	Cited
Dlugos, A et al., Genes Brain Behav, 2010, OPRM1 gene variants modulate amphetamine-induced euphoria in humans	21029375	10.1111/j.1601-183X.2010.00655.x	Cited
Dlugos, AM et al., Neuropsychopharmacology, More aroused, less fatigued: fatty acid amide hydrolase gene polymorphisms influence acute response to amphetamine	19890266	10.1038/npp.2009.166	Cited
Dlugos, AM et al., Psychopharmacology (Berl), Further evidence of association between amphetamine response and SLC6A2 gene variants	19727679	10.1007/s00213-009-1628-y	Cited
Drakenberg, K et al., Proc Nat Acad Sci, 2006, μ Opioid receptor A118G polymorphism in association with striatal opioid neuropeptide gene expression in heroin abusers	16682632	10.1073/pnas.0600871103	Cited
DuPaul, G et al., ADHD rating scales-IV: checklists, 1998	—	—	—
Egan, MF et al., Cell, 2003, The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function	12553913	10.1016/s0092-8674(03)00035-7	Cited
Eisenberg, DTA et al., BBF, 2007, Examining impulsivity as an endophenotype using a behavioral approach: a DRD2 TaqI A and DRD4 48-bp VNTR association study	17214892	10.1186/1744-9081-3-2	Cited
Engeli, S, J Neuroendocrinol, 2008, Dysregulation of the endocannabinoid system in obesity	18426509	10.1111/j.1365-2826.2008.01683.x	Cited
Ezaki, N et al., Ann N Y Acad Sci, 2008, Short allele of 5-HTTLPR as a risk factor for the development of psychosis in Japanese methamphetamine abusers	18991848	10.1196/annals.1432.011	Cited
Faraone, S et al., Am J Psychiatry, 2001, Meta-analysis of the association between the 7-repeat allele of the dopamine D4 receptor gene and attention deficit hyperactivity disorder	11431226	10.1176/appi.ajp.158.7.1052	Cited
Farrer, L et al., Arch Gen Psychiatry, 2009, Association of variants in MANEA with cocaine-related behaviors	19255376	10.1001/archgenpsychiatry.2008.538	Cited
Fergusson, D et al., Arch Gen Psychiatry, 2003, Early reactions to cannabis predict later dependence	14557149	10.1001/archpsyc.60.10.1033	Cited
Filbey, F et al., Neuropsychopharmacology, 2009, Individual and additive effects of the CNR1 and FAAH Genes on brain response to marijuana cues	20010552	10.1038/npp.2009.200	Cited
Flanagin, B et al., Am J Med Genet Part B Neuropsychiatr Genet, 2006, An association study of the brain-derived neurotrophic factor Val66Met polymorphism and amphetamine response	16823800	10.1002/ajmg.b.30327	Cited
Friedel, S et al., Mol Psychiatry, 2007, Association and linkage of allelic variants of the dopamine transporter gene in ADHD	17579611	10.1038/sj.mp.4001986	Cited
Fuke, S et al., Pharmacogenomics J, 2001, The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression	11911442	10.1038/sj.tpj.6500026	Cited
Furberg, H et al., Nat Genet, 2010, Genome-wide meta-analyses identify multiple loci associated with smoking behavior	20418890	10.1038/ng.571	Cited
Fuxe, K et al., J Mol Neurosci, 2005, Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function	16012194	10.1385/JMN:26:2-3:209	Cited
Gelernter, J et al., Neuropsychopharmacology, 1994, Genetic association between dopamine transporter protein alleles and cocaine-induced paranoia	7865100	10.1038/sj.npp.1380106	Cited
Greengard, P, Science, 2001, The neurobiology of slow synaptic transmission	11691979	10.1126/science.294.5544.1024	Cited
Grigorenko, E et al., Aggress Behav, 2010, Aggressive behavior, related conduct problems, and variation in genes affecting dopamine turnover	20127808	10.1002/ab.20339	Cited
Guindalini, C et al., Proc Natl Acad Sci U S A, 2006, A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample	16537431	10.1073/pnas.0504789103	Cited
Guy, W, ECDEU assessment manual for psychopharmacology, 1976, Clinical global impressions	—	—	—
Haenisch, B et al., Am J Med Genet Part B Neuropsychiatr Genet, 2009, Association of major depression with rare functional variants in norepinephrine transporter and serotonin1A receptor genes	19105200	10.1002/ajmg.b.30912	Cited
Haertzen, C et al., Drug Alcohol Depend, 1983, Reinforcements from the first drug experience can predict later drug habits and/or addiction: results with coffee, cigarettes, alcohol, barbiturates, minor and major tranquilizers, stimulants, marijuana, hallucinogens, heroin, opiates and cocaine	6134605	10.1016/0376-8716(83)90076-5	Cited
Hamarman, S et al., J Child Adolescent Psychopharmacology, 2004, Dopamine receptor 4 (DRD4) 7-repeat allele predicts methylphenidate dose response in children with attention deficit hyperactivity disorder: a pharmacogenetic study	15662148	10.1089/cap.2004.14.564	Cited
Hamidovic, A et al., Behav Genet, Polymorphisms in dopamine transporter (SLC6A3) are associated with stimulant effects of d-amphetamine: an exploratory pharmacogenetic study using healthy volunteers	20091113	10.1007/s10519-009-9331-7	Cited
Hamidovic, A et al., Exp Clin Psychopharmacol, 2009, Evaluation of genetic variability in the dopamine receptor D2 in relation to behavioral inhibition and impulsivity/sensation seeking: an exploratory study with d-amphetamine in healthy participants	19968402	10.1037/a0017840	Cited
Hamidovic, A et al., Psychiatr Genet, Catechol-O-methyltransferase val158met genotype modulates sustained attention in both the drug-free state and in response to amphetamine	20414144	10.1097/YPG.0b013e32833a1f3c	Cited
Hashimoto, K et al., Brain Res Rev, 2004, Critical role of brain-derived neurotrophic factor in mood disorders	15145621	10.1016/j.brainresrev.2004.02.003	Cited
Heaton, RK et al., Wisconsin card sorting test manual, 1993	—	—	—
Hohoff, C et al., Am J Med Genet Part B Neuropsychiatr Genet, 2005, Interindividual variation in anxiety response to amphetamine: possible role for adenosine A2A receptor gene variants	16118787	10.1002/ajmg.b.30228	Cited
Holdstock, L et al., Alcohol Clin Exp Res, 2001, Individual differences in responses to ethanol and d-amphetamine: a within-subject study	11329494	—	Cited
Hranilovic, D et al., Biol Psychiatry, 2004, Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expression	15158428	10.1016/j.biopsych.2004.01.029	Cited
Hu, X et al., Am J Human Genet, 2006, Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder	16642437	10.1086/503850	Cited
Huang, C et al., Am J Med Genet Part B: Neuropsychiatr Genet, 2008, Autism and serotonin transporter gene polymorphisms: a systematic review and meta-analysis	18286633	10.1002/ajmg.b.30720	Cited
Hyman, C et al., Nature, 1991, BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra	2005978	10.1038/350230a0	Cited
Ide, S et al., Ann N Y Acad Sci, 2004, Gene polymorphisms of the mu opioid receptor in methamphetamine abusers	15542732	10.1196/annals.1316.039	Cited
Ide, S et al., Pharmacogenomics J, 2006, Linkage disequilibrium and association with methamphetamine dependence/psychosis of mu-opioid receptor gene polymorphisms	16402083	10.1038/sj.tpj.6500355	Cited
Johanson, C et al., Psychopharmacology (Berl), 1980, Drug preference and mood in humans: diazepam	6779334	10.1007/BF00433061	Cited
Johansson, I et al., Cytogenet Genome Res, 2008, CNVs of human genes and their implication in pharmacogenetics	19287156	10.1159/000184709	Cited
Johansson, S et al., Am J Med Genet Part B Neuropsychiatr Genet, 2008, Genetic analyses of dopamine related genes in adult ADHD patients suggest an association with the DRD5-microsatellite repeat, but not with DRD4 or SLC6A3 VNTRs	18081165	10.1002/ajmg.b.30662	Cited
Joober, R et al., Neuropsychopharmacology, 2007, Dopamine transporter 3′-UTR VNTR genotype and ADHD: a pharmaco-behavioural genetic study with methylphenidate	17063150	10.1038/sj.npp.1301240	Cited
Kalayasiri, R et al., Biol Psychiatry, 2007, Dopamine beta-hydroxylase gene (DbetaH) -1021C–>T influences self-reported paranoia during cocaine self-administration	17157269	10.1016/j.biopsych.2006.08.012	Cited
Kato, M et al., Mol Psychiatry, 2008, Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder	18982004	10.1038/mp.2008.116	Cited
Kaufman, J et al., J Am Acad Child Adolesc Psychiatry, 1997, Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data	9204677	10.1097/00004583-199707000-00021	Cited
Kaufman, S et al., Pharmacol Rev, 1965, Dopamine-β-hydroxylase	14294032	—	Cited
Kendler, K et al., Acta Psychiatr Scand, 1999, Hallucinogen, opiate, sedative and stimulant use and abuse in a population-based sample of female twins	10353453	10.1111/j.1600-0447.1999.tb07243.x	Cited
Kendler, K et al., Psychol Med, 2005, Genetic and environmental influences on illicit drug use and tobacco use across birth cohorts	16168157	10.1017/S0033291705004964	Cited
Kendler, KS et al., Am J Psychiatry, 2003, Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins	12668357	10.1176/appi.ajp.160.4.687	Cited
Kendler, KS et al., Arch Gen Psychiatry, 2000, Illicit psychoactive substance use, heavy use, abuse, and dependence in a US population-based sample of male twins	10711912	10.1001/archpsyc.57.3.261	Cited
Kirchner, WK, J Exp Psychology, 1958, Age differences in short-term retention of rapidly changing information	13539317	10.1037/h0043688	Cited
Kishi, T et al., Prog Neuropsychopharmacol Biol Psychiatry, 2010, PROKR2 is associated with methamphetamine dependence in the Japanese population	20576534	10.1016/j.pnpbp.2010.05.018	Cited
Kishimoto, M et al., Behav Brain Funct, The frizzled 3 gene is associated with methamphetamine psychosis in the Japanese population	18702828	10.1186/1744-9081-4-37	Cited
Kishimoto, M et al., Biol Psychiatry, The dysbindin gene (DTNBP1) is associated with methamphetamine psychosis	17555717	10.1016/j.biopsych.2007.03.019	Cited
Kobayashi, H et al., Ann N Y Acad Sci, 2004, Study of association between alpha-synuclein gene polymorphism and methamphetamine psychosis/dependence	15542733	10.1196/annals.1316.040	Cited
Kooij, J et al., Am J Med Genet Part B: Neuropsychiatr Genet, 2008, Response to methylphenidate in adults with ADHD is associated with a polymorphism in SLC6A3 (DAT1)	17955457	10.1002/ajmg.b.30586	Cited
Kotaka, T et al., Prog Neuropsychopharmacol Biol Psychiatry, 2009, G72 gene is associated with susceptibility to methamphetamine psychosis	19482054	10.1016/j.pnpbp.2009.05.017	Cited
Kreek, M et al., Nat Neurosci, 2005, Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction	16251987	10.1038/nn1583	Cited
Lachman, H et al., Pharmacogenet Genomics, 1996, Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders	8807664	10.1097/00008571-199606000-00007	Cited
Lamb, RJ et al., J Exp Anal Behav, 1994, Human d-amphetamine drug discrimination: methamphetamine and hydromorphone	7513346	10.1901/jeab.1994.61-169	Cited
Laucht, M et al., J Am Acad Child Adolesc Psychiatry, 2008, Genetic variation in dopamine pathways differentially associated with smoking progression in adolescence	18434921	10.1097/CHI.0b013e31816bff77	Cited
Lee, A et al., 2006, DRD4-7R mediated response to amphetamine in normal subjects	—	—	—
Lee, Y et al., Neurosci Lett, 2005, Norepinephrine transporter (NET) promoter and 5′-UTR polymorphisms: association analysis in panic disorder	15722184	10.1016/j.neulet.2004.11.063	Cited
Levran, O et al., Genes Brain Behav, 2008, Genetic susceptibility to heroin addiction: a candidate gene association study	18518925	10.1111/j.1601-183X.2008.00410.x	Cited
Li, D et al., Hum Mol Genet, 2006, Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD)	16774975	10.1093/hmg/ddl152	Cited
Li, T et al., Am J Med Genet Part B Neuropsychiatr Genet, 2004, Association analysis of the DRD4 and COMT genes in methamphetamine abuse	15274053	10.1002/ajmg.b.30024	Cited
Lichter, J et al., Hum Mol Genet, 1993, A hypervariable segment in the human dopamine receptor D4 (DRD4) gene	8353495	10.1093/hmg/2.6.767	Cited
Lin, L et al., Drug Metab Dispos, 1997, Oxidation of methamphetamine and methylenedioxymethamphetamine by CYP2D6	9311621	—	Cited
Logan, G et al., J Exp Psychology, 1984, On the ability to inhibit simple and choice reaction time responses: a model and a method	6232345	10.1037//0096-1523.10.2.276	Cited
Lohoff, F et al., Neuropsychopharmacology, 2008, Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence	18704099	10.1038/npp.2008.126	Cited
Lott, D et al., Am J Addict, 2006, Serotonin transporter genotype and acute subjective response to amphetamine	16966188	10.1080/10550490600859868	Cited
Lott, D et al., Neuropsychopharmacology, 2005, Dopamine transporter gene associated with diminished subjective response to amphetamine	15602501	10.1038/sj.npp.1300637	Cited
Madsen, MV et al., J Psychopharmacol (Oxford), 2006, Effects of the cannabinoid CB1 receptor agonist CP55, 940 and antagonist SR141716A on d-amphetamine-induced behaviours in Cebus monkeys	16533866	10.1177/0269881106063816	Cited
Manor, I et al., Am J Med Genet Part B Neuropsychiatr Genet, 2008, Association between trypotphan hydroxylase 2, performance on a continuance performance test and response to methylphenidate in ADHD participants	18213624	10.1002/ajmg.b.30702	Cited
Martin, WRSJW et al., Clin Pharmacol Therap, 1971, Physiologic, subjective and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine and methylphenidate in man	5554941	10.1002/cpt1971122part1245	Cited
Matsuzawa, D et al., Am J Psychiatry, 2007, Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with methamphetamine psychosis	17606663	10.1176/ajp.2007.164.7.1105	Cited
Mattay, V et al., Proc Natl Acad Sci U S A, 2003, Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine	12716966	10.1073/pnas.0931309100	Cited
McGough, J et al., J Am Acad Child Adolesc Psychiatry, 2006, Pharmacogenetics of methylphenidate response in preschoolers with ADHD	17023870	10.1097/01.chi.0000235083.40285.08	Cited
McKinney, MK et al., Annu Rev Biochem, 2005, Structure and function of fatty acid amide hydrolase	15952893	10.1146/annurev.biochem.74.082803.133450	Cited
McNair, D et al., POMS manual for profile of mood states, 1971	—	—	—
Mick, E et al., Am J Med Genet Part B Neuropsychiatr Genet, 2008, Genome-wide association study of response to methylphenidate in 187 children with attention-deficit/hyperactivity disorder	18821564	10.1002/ajmg.b.30865	Cited
Mick, E et al., J Am Acad Child Adolesc Psychiatry, 2010, Family-based genome-wide association scan of attention-deficit/hyperactivity disorder	20732626	10.1016/j.jaac.2010.02.014	Cited
Min, W et al., Psychopharmacology (Berl), 2009, Monoamine transporter gene polymorphisms affect susceptibility to depression and predict antidepressant response	19468717	10.1007/s00213-009-1550-3	Cited
Morita, Y et al., Am J Med Genet B Neuropsychiatr Genet, 2008, The glycine transporter 1 gene (GLYT1) is associated with methamphetamine-use disorder	17582620	10.1002/ajmg.b.30565	Cited
Munafò, M et al., Biol Psychiatry, 2008, Association of the dopamine D4 receptor (DRD4) gene and approach-related personality traits: meta-analysis and new data	17574217	10.1016/j.biopsych.2007.04.006	Cited
Nakamura, K et al., Hum Genet, 2006, Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations	16807759	10.1007/s00439-006-0189-y	Cited
Nakamura, K et al., Neurosci Lett, 2009, An association study of monoamine oxidase A (MAOA) gene polymorphism in methamphetamine psychosis	19368859	10.1016/j.neulet.2009.02.048	Cited
Nakamura, M et al., Mol Psychiatry, 2000, The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants	10673766	10.1038/sj.mp.4000698	Cited
Nakatome, M et al., Leg Med (Tokyo), 2009, Association between the GST genetic polymorphisms and methamphetamine abusers in the Japanese population	19254865	10.1016/j.legalmed.2009.01.095	Cited
Nemoda, Z et al., Neuropharmacology, 2009, Carboxylesterase 1 gene polymorphism and methylphenidate response in ADHD	19733552	10.1016/j.neuropharm.2009.08.014	Cited
Neville, M et al., Hum Mutat, 2004, Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23. 1	15146457	10.1002/humu.20039	Cited
Nishiyama, T et al., Pharmacogenomics J, 2005, Haplotype association between GABAA receptor gamma2 subunit gene (GABRG2) and methamphetamine use disorder	15772696	10.1038/sj.tpj.6500292	Cited
Nomura, A et al., Neurosci Lett, 2006, Genetic variant of prodynorphin gene is risk factor for methamphetamine dependence	16529859	10.1016/j.neulet.2006.02.038	Cited
Nurnberger, J et al., Psychoneuroendocrinology, 1982, Behavioral, biochemical and neuroendocrine responses to amphetamine in normal twins and ‘well-state’ bipolar patients	6891082	10.1016/0306-4530(82)90009-9	Cited
Ohgake, S et al., Addict Bio, 2005, Functional polymorphism of the NQO2 gene is associated with methamphetamine psychosis	16191666	10.1080/13556210500123423	Cited
Oroszi, G et al., Alcohol Clin Exp Res, 2009, OPRM1 Asn40Asp predicts response to naltrexone treatment: a haplotype-based approach	19053977	10.1111/j.1530-0277.2008.00846.x	Cited
Otani, K et al., Neurosci Lett, 2008, Reduced CYP2D6 activity is a negative risk factor for methamphetamine dependence	18280655	10.1016/j.neulet.2008.01.033	Cited
Palmer, AA et al., Mamm Genome, 2005, Gene expression differences in mice divergently selected for methamphetamine sensitivity	16104378	10.1007/s00335-004-2451-8	Cited
Phillips, T et al., Neurosci Biobehav Rev, 2008, Behavioral genetic contributions to the study of addiction-related amphetamine effects	18207241	10.1016/j.neubiorev.2007.10.008	Cited
Purper-Ouakil, D et al., Am J Med Genet Part B Neuropsychiatr Genet, 2008, Pharmacogenetics of methylphenidate response in attention deficit/hyperactivity disorder: association with the dopamine transporter gene (SLC6A3)	18563707	10.1002/ajmg.b.30809	Cited
Rausch, J, Prog Neuropsychopharmacol Biol Psychiatry, 2005, Initial conditions of psychotropic drug response: studies of serotonin transporter long promoter region (5-HTTLPR), serotonin transporter efficiency, cytokine and kinase gene expression relevant to depression and antidepressant outcome	16005136	10.1016/j.pnpbp.2005.03.011	Cited
Reitan, R, Percept Mot Skills, 1958, Validity of the trail making test as an indicator of organic brain damage	—	—	—
Risch, N et al., JAMA, 2009, Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis	19531786	10.1001/jama.2009.878	Cited
Rodriguez-Jimenez, R et al., Eur Psychiatry, 2006, The TaqIA polymorphism linked to the DRD2 gene is related to lower attention and less inhibitory control in alcoholic patients	16139486	10.1016/j.eurpsy.2005.05.010	Cited
Rohde, L et al., Synapse, 2003, Dopamine transporter gene, response to methylphenidate and cerebral blood flow in attention-deficit/hyperactivity disorder: a pilot study	12619042	10.1002/syn.10186	Cited
Roman, T et al., Am J Med Genet Part B: Neuropsychiatr Genet, 2001, Attention-deficit hyperactivity disorder: a study of association with both the dopamine transporter gene and the dopamine D4 receptor gene	11449401	10.1002/ajmg.1408	Cited
Rosvold, HE et al., J Consult Psychology, 1956, A continuous performance test of brain damage	13367264	10.1037/h0043220	Cited
Sabol, SZ et al., Hum Genet, 1998, A functional polymorphism in the monoamine oxidase A gene promoter	9799080	10.1007/s004390050816	Cited
Seiden, L et al., Annu Rev Pharmacol Toxicol, 1993, Amphetamine: effects on catecholamine systems and behavior	8494354	10.1146/annurev.pa.33.040193.003231	Cited
Sekine, Y et al., Arch Gen Psychiatry, 2006, Brain serotonin transporter density and aggression in abstinent methamphetamine abusers	16389202	10.1001/archpsyc.63.1.90	Cited
Sevak, RJ et al., J Pharmacol Exp Ther, 2009, Discriminative stimulus and subject-rated effects of methamphetamine, d-amphetamine, methylphenidate, and triazolam in methamphetamine-trained humans	19104030	10.1124/jpet.108.147124	Cited
Shi, J et al., Schizophr Res, 2008, Genetic associations with schizophrenia: meta-analyses of 12 candidate genes	18715757	10.1016/j.schres.2008.06.016	Cited
Shugart, Y et al., Eur J Hum Genet, 2009, Two British women studies replicated the association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) and BMI	19209189	10.1038/ejhg.2008.272	Cited
Spanagel, R et al., Proc Natl Acad Sci, 1992, Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway	1347943	10.1073/pnas.89.6.2046	Cited
Stein, M et al., Neuropsychopharmacology, 2005, Dopamine transporter genotype and methylphenidate dose response in children with ADHD	15827573	10.1038/sj.npp.1300718	Cited
Stroop, J, J Exp Psychology, 1935, Studies of interference in serial verbal reactions	—	—	—
Sulzer, D et al., Prog Neurobiol, 2005, Mechanisms of neurotransmitter release by amphetamines: a review	15955613	10.1016/j.pneurobio.2005.04.003	Cited
Suzuki, A et al., Psychiatr Genet, 2006, An association study between catechol-O-methyl transferase gene polymorphism and methamphetamine psychotic disorder	16829779	10.1097/01.ypg.0000218613.35139.cd	Cited
Thakur, G et al., BMC Psychiatry, 2010, The 5-HTTLPR polymorphism of the serotonin transporter gene and short term behavioral response to methylphenidate in children with ADHD	20569447	10.1186/1471-244X-10-50	Cited
Tsuang, MT et al., Am J Med Genet, 1996, Genetic influences on DSM-III-R drug abuse and dependence: a study of 3,372 twin pairs	8886164	10.1002/(SICI)1096-8628(19960920)67:5<473::AID-AJMG6>3.0.CO;2-L	Cited
Tsunoka, T et al., Prog Neuropsychopharmacol Biol Psychiatry, 2010, Association analysis of GRM2 and HTR2A with methamphetamine-induced psychosis and schizophrenia in the Japanese population	20211215	10.1016/j.pnpbp.2010.03.002	Cited
Tunbridge, E et al., Biol Psychiatry, 2006, Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond	16476412	10.1016/j.biopsych.2005.10.024	Cited
Uhl, G et al., FASEB J, 2000, The VMAT2 gene in mice and humans: amphetamine responses, locomotion, cardiac arrhythmias, aging, and vulner-ability to dopaminergic toxins	11099463	10.1096/fj.00-0205rev	Cited
Uhl, G, NeuroRx, 2006, Molecular genetics of addiction vulnerability	16815213	10.1016/j.nurx.2006.05.006	Cited
Uhl, GR et al., Arch Gen Psychiatry, 2008, Genome-wide association for methamphetamine dependence: convergent results from 2 samples	18316681	10.1001/archpsyc.65.3.345	Cited
Ujike, H et al., Pharmacogenomics J, 2003, Nine- or fewer repeat alleles in VNTR polymorphism of the dopamine transporter gene is a strong risk factor for prolonged methamphetamine psychosis	12931138	10.1038/sj.tpj.6500189	Cited
Ujike, H et al., Prog Neuropsychopharmacol Biol Psychiatry, 2009, Genetic variants of D2 but not D3 or D4 dopamine receptor gene are associated with rapid onset and poor prognosis of methamphetamine psychosis	19275926	10.1016/j.pnpbp.2009.02.019	Cited
van de Giessen, E et al., J Nucl Med, 2009, Striatal dopamine transporter availability associated with polymorphisms in the dopamine transporter gene SLC6A3	19091889	10.2967/jnumed.108.053652	Cited
Van Dyck, C et al., J Nucl Med, 2005, Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene	15872345	—	Cited
Vandenbergh, D et al., Genomics, 1992, Human dopamine transporter gene (DAT1) maps to chromosome 5p15. 3 and displays a VNTR	1478653	10.1016/s0888-7543(05)80138-7	Cited
Vandenbergh, DJ et al., Am J Med Genet, 1997, High-activity catechol-O-methyltransferase allele is more prevalent in polysubstance abusers	9259381	—	Cited
Veenstra-VanderWeele, J et al., Neuropsychopharmacology, 2006, Association between the casein kinase 1 epsilon gene region and subjective response to D-amphetamine	16237383	10.1038/sj.npp.1300936	Cited
Warwick, JM, Metab Brain Dis, 2004, Imaging of brain function using SPECT	15214511	10.1023/b:mebr.0000027422.48744.a3	Cited
Wechsler, D, Acad Med, 1958, The measurement and appraisal of adult intelligence	—	—	—
Yang, A et al., Psychopharmacology (Berl), 2010, Genetics of caffeine consumption and responses to caffeine	20532872	10.1007/s00213-010-1900-1	Cited
Yu, Y et al., Hum Genet, 2008, Substance dependence low-density whole genome association study in two distinct American populations	18438686	10.1007/s00439-008-0501-0	Cited
Zabetian, C et al., Am J Human Genet, 2001, A quantitative-trait analysis of human plasma-dopamine [beta]-hydroxylase activity: evidence for a major functional polymorphism at the DBH locus	11170900	10.1086/318198	Cited
Zabetian, C et al., Am J Human Genet, 2003, The structure of linkage disequilibrium at the DBH locus strongly influences the magnitude of association between diallelic markers and plasma dopamine [beta]-hydroxylase activity	12730829	10.1086/375499	Cited
Zhang, X et al., Cell Mol Life Sci, 2006, Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2	16378243	10.1007/s00018-005-5417-4	Cited
Zhang, Y et al., Proc Nat Acad Sci, 2007, Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory	18077373	10.1073/pnas.0707106104	Cited
Šerý, O et al., J Mol Neurosci, 2010, A118G polymorphism of OPRM1 gene is associated with schizophrenia	20112002	10.1007/s12031-010-9327-z	Cited
Šerý, O et al., Physiol Res, 2001, The association study of DRD2, ACE and AGT gene polymorphisms and metamphetamine dependence	11300226	—	Cited

In this knowledge base

Title	Year	PMID
Genome-wide association study of stimulant dependence.	2021	34226506

External

Title	Authors	Journal	Year	Link
A 24-Month Effects of Methylphenidate Use on Growth in Children and Adolescents With Attention Deficit Hyperactivity Disorder.	Lee Y et al.	—	2022	→
Affective response to physical activity as a deep phenotype in a non-randomized pilot study.	Lee HH et al.	—	2022	→
Functional Genomic Analysis of Amphetamine Sensitivity in <i>Drosophila</i>.	Karam CS et al.	—	2022	→
Affective response to physical activity as an intermediate phenotype.	Lee HH et al.	—	2021	→
Atomoxetine modulates the contribution of low-level signals during free viewing of natural images in rhesus monkeys.	Reynaud AJ et al.	—	2021	→
Functional validation of a finding from a mouse genome-wide association study shows that Azi2 influences the acute locomotor stimulant response to methamphetamine.	Zhou X et al.	—	2021	→
Genome-wide association study of stimulant dependence.	Cox J et al.	—	2021	→
Methylphenidate and atomoxetine treatment negatively affect physical growth indexes of school-age children and adolescents with attention-deficit/hyperactivity disorder.	Deng L et al.	—	2021	→
Functional validation of a finding from a mouse genome-wide association study demonstrates that a mutant allele of<i>Azi2</i>alters sensitivity to methamphetamine	Zhou X et al.	—	2020	—
The Effects of Methylphenidate Treatment on Child Growth in Thai Children and Adolescents with Attention-Deficit/Hyperactivity Disorder.	Koonrungsesomboon K et al.	—	2020	→
DRD2 and ANKK1 genes associate with late-onset heroin dependence in men.	Tsou CC et al.	—	2019	→
Effects of familial risk and stimulant drug use on the anticipation of monetary reward: an fMRI study.	Just AL et al.	—	2019	→
Pharmacological potential of methylxanthines: Retrospective analysis and future expectations.	Monteiro J et al.	—	2019	→
Lisdexamfetamine: chemistry, pharmacodynamics, pharmacokinetics, and clinical efficacy, safety, and tolerability in the treatment of binge eating disorder.	Ward K et al.	—	2018	→
Rewarding effects of physical activity predict sensitivity to the acute subjective effects of d-amphetamine in healthy volunteers.	Pester MS et al.	—	2018	→
Solriamfetol for the treatment of daytime sleepiness in obstructive sleep apnea.	Abad VC et al.	—	2018	→
Increased 5-hydroxymethylation levels in the hippocampus of rat extinguished from cocaine self-administration.	Sadakierska-Chudy A et al.	—	2017	→
Methylphenidate and Atomoxetine-Responsive Prefrontal Cortical Genetic Overlaps in "Impulsive" SHR/NCrl and Wistar Rats.	Dela Peña I et al.	—	2017	→
Pharmacogenetics of stimulant abuse liability: association of CDH13 variant with amphetamine response in a racially-heterogeneous sample of healthy young adults.	Leventhal AM et al.	—	2017	→
Individual differences in timing of peak positive subjective responses to d-amphetamine: Relationship to pharmacokinetics and physiology.	Smith CT et al.	—	2016	→
Structure-Bioactivity Relationships of Methylxanthines: Trying to Make Sense of All the Promises and the Drawbacks.	Monteiro JP et al.	—	2016	→
A variant in ANKK1 modulates acute subjective effects of cocaine: a preliminary study.	Spellicy CJ et al.	—	2014	→
Personality and the acute subjective effects of d-amphetamine in humans.	Kirkpatrick MG et al.	—	2013	→
Psychopharmacology of theobromine in healthy volunteers.	Baggott MJ et al.	—	2013	→
Congenic dissection of a major QTL for methamphetamine sensitivity implicates epistasis.	Bryant CD et al.	—	2012	→
Genome-wide association for methamphetamine sensitivity in an advanced intercross mouse line.	Parker CC et al.	—	2012	→
Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).	Hart AB et al.	—	2012	→
Methamphetamine-induced conditioned place preference in LG/J and SM/J mouse strains and an F45/F46 advanced intercross line.	Bryant CD et al.	—	2012	→