Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.
paper
Cited
Public
Unavailable
- Authors
- Spanagel, R; Herz, A; Shippenberg, T S
- Year
- 1992
- Journal
- Proceedings of the National Academy of Sciences of the United States of America
- PMID
- 1347943
- DOI
- 10.1073/pnas.89.6.2046
- PMCID
- PMC48593
The mesolimbic dopaminergic system has been implicated in mediating the motivational effects of opioids and other drugs of abuse. The site of action of opioids within this system and the role of endogenous opioid peptides in modulating dopamine activity therein remain unknown. Employing the technique of in vivo microdialysis and the administration of highly selective opioid ligands, the present study demonstrates the existence of tonically active and functionally opposing mu and kappa opioid systems that regulate dopamine release in the nucleus accumbens, the major terminal area of A10 dopaminergic neurons. Thus, stimulation of mu-type receptors in the ventral tegmental area, the site of origin of A10 dopaminergic neurons, increases dopamine release whereas the selective blockade of this opioid receptor type results in a significant decrease in basal dopamine release. In contrast, stimulation of kappa-type receptors within the nucleus accumbens decreases dopamine release whereas their selective blockade markedly increases basal dopamine release. These data show that tonic activation of mu and kappa receptors is required for the maintenance of basal dopamine release in the nucleus accumbens. In view of the postulated role of the mesolimbic system in the mediation of drug-induced alterations in mood and affect, such findings may have implications for the treatment of opiate dependence and affective disorders.
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| Can the incentive-sensitization theory of addiction incorporate addiction to opioid drugs? | Robinson TE et al. | β | 2026 | β |
| Chronic morphine differentially impacts glutamatergic synaptic plasticity in the ventral tegmental area of adult versus adolescent mice. | Edwards JG et al. | β | 2026 | β |
| Kappa opioid receptor control of motivated behavior revisited. | Farahbakhsh ZZ et al. | β | 2026 | β |
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| Disrupted circadian rhythms and opioid-mediated adverse effects: Bidirectional relationship and putative mechanisms. | Mehranfard N et al. | β | 2025 | β |
| Dynorphin modulates reward-seeking actions through a pallido-amygdala cholinergic circuit. | Sun Q et al. | β | 2025 | β |
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| Inhibitory effects of the selective ΞΌ-opioid receptor antagonist UD-030 on methamphetamine-induced conditioned place preference. | Ide S et al. | β | 2025 | β |
| Kappa opioid receptors diminish spontaneous dopamine signals in awake mice through multiple mechanisms. | Wallace CW et al. | β | 2025 | β |
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| Melanin-Concentrating Hormone (MCH): Role in Mediating Reward-Motivated and Emotional Behavior and the Behavioral Disturbances Produced by Repeated Exposure to Reward Substances. | Karatayev O et al. | β | 2025 | β |
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| The Dopamine System in Mediating Alcohol Effects in Humans. | Beck A et al. | β | 2025 | β |
| The impact of chronic heroin addiction on creative cognition: an EEG study based on divergent thinking. | Fu W et al. | β | 2025 | β |
| The influence of morphine treatment on the opioid propeptide gene expression in the forebrain of two inbred mouse strains with different sensitivity to opioids. | ZiΓ³Εkowska B et al. | β | 2025 | β |
| Threonine-53 Phosphorylation of Dopamine Transporter Dictates ΞΊ-Opioid Receptor-Mediated Locomotor Suppression, Aversion, and Cocaine Reward. | Durairaj RV et al. | β | 2025 | β |
| Acupuncture in the treatment of cocaine addiction: how does it work? | Sun L et al. | β | 2024 | β |
| Co-targeting the kappa opioid receptor and dopamine transporter reduces motivation to self-administer cocaine and partially reverses dopamine system dysregulation. | Estave PM et al. | β | 2024 | β |
| Dopamine D2R and opioid MOR availability in autism spectrum disorder | Noppari T et al. | β | 2024 | β |
| G protein-coupled receptor modulation of striatal dopamine transmission: Implications for psychoactive drug effects. | Littlepage-Saunders M et al. | β | 2024 | β |
| Kappa-opioid receptor antagonism in the nucleus accumbens shell distinguishes escalated alcohol consumption and negative affective-like behavior from physiological withdrawal in alcohol-dependence. | Lepreux G et al. | β | 2024 | β |
| Kappa opioid receptor availability predicts severity of anhedonia in schizophrenia. | Slifstein M et al. | β | 2024 | β |
| Mapping functional traces of opioid memories in the rat brain. | Gomes-Ribeiro J et al. | β | 2024 | β |
| Neurocircuitry underlying the actions of glucagon-like peptide 1 and peptide YY<sub>3</sub><sub>-</sub><sub>36</sub> in the suppression of food, drug-seeking, and anxiogenesis. | Dumiaty Y et al. | β | 2024 | β |
| Neurotransmitters crosstalk and regulation in the reward circuit of subjects with behavioral addiction. | Peng Z et al. | β | 2024 | β |
| Opioid Mechanisms and the Treatment of Depression. | Jelen LA et al. | β | 2024 | β |
| Targeting mitochondrial dynamics of morphine-responsive dopaminergic neurons ameliorates opiate withdrawal. | Jiang C et al. | β | 2024 | β |
| Voluntary Exercise Ameliorates Chronic Ethanol Withdrawal-Induced Adaptations of Opioid Receptor Expression in the Nucleus Accumbens, Dopamine Release, and Ethanol Consumption. | Nelson CA et al. | β | 2024 | β |
| Adolescence as a critical period for nandrolone-induced muscular strength in relation to abuse liability, alone and in conjunction with morphine, using accumbal dopamine efflux in freely moving rats. | Kawashima H et al. | β | 2023 | β |
| Antagonism of kappa opioid receptors accelerates the development of L-DOPA-induced dyskinesia in a preclinical model of moderate dopamine depletion. | Flores AJ et al. | β | 2023 | β |
| Cannabidiol and brain function: current knowledge and future perspectives. | Schouten M et al. | β | 2023 | β |
| Cocaine self-administration augments kappa opioid receptor system-mediated inhibition of dopamine activity in the mesolimbic dopamine system. | Estave PM et al. | β | 2023 | β |
| Contribution of the opioid system to depression and to the therapeutic effects of classical antidepressants and ketamine. | Adzic M et al. | β | 2023 | β |
| Dichotomous regulation of striatal plasticity by dynorphin. | Yang R et al. | β | 2023 | β |
| Experimental Study: Interleukin-31 Augments Morphine-Induced Antinociceptive Activity and Suppress Tolerance Development in Mice. | Arai I et al. | β | 2023 | β |
| Kappa opioid receptor agonist U50,488 inhibits dopamine more in caudal than rostral nucleus accumbens core. | Karkhanis AN et al. | β | 2023 | β |
| Naltrexone engages a brain reward network in the presence of reward-predictive distractor stimuli in males. | Spencer CN et al. | β | 2023 | β |
| Pain-related cortico-limbic plasticity and opioid signaling. | Neugebauer V et al. | β | 2023 | β |
| Recapitulating phenotypes of alcohol dependence via overexpression of Oprk1 in the ventral tegmental area of non-dependent TH::Cre rats. | Lepreux G et al. | β | 2023 | β |
| The Involvement of Endogenous Enkephalins in Glucose Homeostasis. | Escolero V et al. | β | 2023 | β |
| The Role of Mu Opioid Receptors in High Fat Diet-Induced Reward and Potentiation of the Rewarding Effect of Oxycodone. | Iqbal A et al. | β | 2023 | β |
| Analgesic Effects of Oxycodone in Combination With Risperidone or Ziprasidone: Results From a Pilot Randomized Controlled Trial in Healthy Volunteers. | Nagpal AS et al. | β | 2022 | β |
| Benzylaminofentanyl derivates: Discovery of bifunctional ΞΌ opioid and Ο<sub>1</sub> receptor ligands as novel analgesics with reduced adverse effects. | Zhuang T et al. | β | 2022 | β |
| Brain Mechanisms of Exercise-Induced Hypoalgesia: To Find a Way Out from "Fear-Avoidance Belief". | Kami K et al. | β | 2022 | β |
| Brain opioid segments and striatal patterns of dopamine release induced by naloxone and morphine. | Shokri-Kojori E et al. | β | 2022 | β |
| Cellular and behavioral basis of cannabinioid and opioid interactions: Implications for opioid dependence and withdrawal. | Mohammadkhani A et al. | β | 2022 | β |
| Chronic early-life lead exposure sensitizes adolescent rats to cocaine: Role of the dopaminergic system. | Albores-Garcia D et al. | β | 2022 | β |
| Endogenous Opioid Dynorphin Is a Potential Link between Traumatic Brain Injury, Chronic Pain, and Substance Use Disorder. | Best KM et al. | β | 2022 | β |
| Endogenous opioid systems alterations in pain and opioid use disorder. | Higginbotham JA et al. | β | 2022 | β |
| Friend of the Devil: Negative Social Influences Driving Substance Use Disorders. | Pomrenze MB et al. | β | 2022 | β |
| Goofballing of Opioid and Methamphetamine: The Science Behind the Deadly Cocktail. | Hazani HM et al. | β | 2022 | β |
| Hazardous drinking and alcohol use disorders. | MacKillop J et al. | β | 2022 | β |
| Kappa Opioid Signaling at the Crossroads of Chronic Pain and Opioid Addiction. | Cahill CM et al. | β | 2022 | β |
| KOR Control over Addiction Processing: An Exploration of the Mesolimbic Dopamine Pathway. | Estave PM et al. | β | 2022 | β |
| Modulation of 5-HT release by dynorphin mediates social deficits during opioid withdrawal. | Pomrenze MB et al. | β | 2022 | β |
| Optogenetic stimulation of lateral hypothalamic orexin/dynorphin inputs in the ventral tegmental area potentiates mesolimbic dopamine neurotransmission and promotes reward-seeking behaviours. | Thomas CS et al. | β | 2022 | β |
| Pharmacogenetics of Addiction Therapy. | Graham DP et al. | β | 2022 | β |
| Pleiotropic Effects of Kappa Opioid Receptor-Related Ligands in Non-human Primates. | Ko MC et al. | β | 2022 | β |
| Role of the striatal dopamine, GABA and opioid systems in mediating feeding and fat intake. | Joshi A et al. | β | 2022 | β |
| The opioid system in depression. | Jelen LA et al. | β | 2022 | β |
| What is better for psychiatry: Titrated or fixed concentrations of nitrous oxide? | Gillman MA | β | 2022 | β |
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| An opponent process for alcohol addiction based on changes in endocrine gland mass. | Karin O et al. | β | 2021 | β |
| Bidirectional role of acupuncture in the treatment of drug addiction. | Lee MY et al. | β | 2021 | β |
| 'Defrosting' music chills with naltrexone: The role of endogenous opioids for the intensity of musical pleasure. | Laeng B et al. | β | 2021 | β |
| Effects of the selective dopamine D<sub>3</sub> receptor antagonist PG01037 on morphine-induced hyperactivity and antinociception in mice. | Botz-Zapp CA et al. | β | 2021 | β |
| Improving the Utility of a Dynorphin Peptide Analogue Using Mannosylated Glycoliposomes. | Lewicky JD et al. | β | 2021 | β |
| Insulin Bidirectionally Alters NAc Glutamatergic Transmission: Interactions between Insulin Receptor Activation, Endogenous Opioids, and Glutamate Release. | Fetterly TL et al. | β | 2021 | β |
| Mechanisms Underlying the Anti-Suicidal Treatment Potential of Buprenorphine. | Cameron CM et al. | β | 2021 | β |
| Mesolimbic opioid-dopamine interaction is disrupted in obesity but recovered by weight loss following bariatric surgery. | Karlsson HK et al. | β | 2021 | β |
| Naloxone precipitated withdrawal increases dopamine release in the dorsal striatum of opioid dependent men. | Shokri-Kojori E et al. | β | 2021 | β |
| Opioid use during pregnancy can impair maternal behavior and the Maternal Brain Network: A literature review. | Wallin CM et al. | β | 2021 | β |
| Opioid withdrawal produces sex-specific effects on fentanyl-vs.-food choice and mesolimbic transcription. | Townsend EA et al. | β | 2021 | β |
| Pain in the neurodegenerating brain: insights into pharmacotherapy for Alzheimer disease and Parkinson disease. | Lawn T et al. | β | 2021 | β |
| Progress in opioid reward research: From a canonical two-neuron hypothesis to two neural circuits. | Galaj E et al. | β | 2021 | β |
| Role of Cannabidiol in the Therapeutic Intervention for Substance Use Disorders. | Navarrete F et al. | β | 2021 | β |
| Samidorphan, an opioid receptor antagonist, attenuates drug-induced increases in extracellular dopamine concentrations and drug self-administration in male Wistar rats. | Cunningham JI et al. | β | 2021 | β |
| Targeting the Opioid Receptors: A Promising Therapeutic Avenue for Treatment in "Heavy Drinking Smokers". | Domi A et al. | β | 2021 | β |
| The Role of Beta-Endorphin in Cocaine-Induced Conditioned Place Preference, Its Extinction, and Reinstatement in Male and Female Mice. | Singh PK et al. | β | 2021 | β |
| The Role of Mesostriatal Dopamine System and Corticostriatal Glutamatergic Transmission in Chronic Pain. | ZiΓ³Εkowska B | β | 2021 | β |
| The Role of the Kappa Opioid System in Comorbid Pain and Psychiatric Disorders: Function and Implications. | Ji MJ et al. | β | 2021 | β |
| The serotonin 2C receptor agonist lorcaserin, alone and in combination with the opioid receptor antagonist naltrexone, attenuates binge-like ethanol drinking. | Tabbara RI et al. | β | 2021 | β |
| Translational value of non-human primates in opioid research. | Ding H et al. | β | 2021 | β |
| Unlucky punches: the vulnerability-stress model for the development of impulse control disorders in Parkinson's disease. | Theis H et al. | β | 2021 | β |
| Adolescent Intermittent Ethanol Exposure Effects on Kappa Opioid Receptor Mediated Dopamine Transmission: Sex and Age of Exposure Matter. | Spodnick MB et al. | β | 2020 | β |
| Buprenorphine is a weak dopamine releaser relative to heroin, but its pretreatment attenuates heroin-evoked dopamine release in rats. | Isaacs DP et al. | β | 2020 | β |
| Cannabinoids and the endocannabinoid system in reward processing and addiction: from mechanisms to interventionsβ©. | Spanagel R | β | 2020 | β |
| Crosstalk Between Kappa Opioid and Dopamine Systems in Compulsive Behaviors. | Escobar ADP et al. | β | 2020 | β |
| Differential Modulation of Ventral Tegmental Area Circuits by the Nociceptin/Orphanin FQ System. | Driscoll JR et al. | β | 2020 | β |
| Effects of a trace amine-associated receptor 1 agonist RO 5263397 on ethanol-induced behavioral sensitization. | Wu R et al. | β | 2020 | β |
| Exploring ΞΌ-Opioid Receptor Splice Variants as a Specific Molecular Target for New Analgesics. | Mizoguchi H et al. | β | 2020 | β |
| Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis. | Pirino BE et al. | β | 2020 | β |
| Neurobehavioral effects of neonatal opioid exposure in mice: Influence of the OPRM1 SNP. | Robinson SA et al. | β | 2020 | β |
| Neuropathic Pain Dysregulates Gene Expression of the Forebrain Opioid and Dopamine Systems. | Wawrzczak-BargieΕa A et al. | β | 2020 | β |
| Opioid receptor modulation of neural circuits in depression: What can be learned from preclinical data? | Puryear CB et al. | β | 2020 | β |
| Pain, Motivation, Migraine, and the Microbiome: New Frontiers for Opioid Systems and Disease. | Parker KE et al. | β | 2020 | β |
| Pharmacotherapeutic management of co-morbid alcohol and opioid use. | Hood LE et al. | β | 2020 | β |
| Physical exercise modifies behavioral and molecular parameters related to opioid addiction regardless of training time. | Rosa HZ et al. | β | 2020 | β |
| Sigma receptor-induced heavy drinking in rats: Modulation by the opioid receptor system. | Valenza M et al. | β | 2020 | β |
| The effects of early life stress on motivated behaviors: A role for gonadal hormones. | Eck SR et al. | β | 2020 | β |
| The neurochemical substrates of habitual and goal-directed control. | Voon V et al. | β | 2020 | β |
| A Neurobehavioral Approach to Addiction: Implications for the Opioid Epidemic and the Psychology of Addiction. | Bechara A et al. | β | 2019 | β |
| Anhedonia in depression symptomatology: Appetite dysregulation and defective brain reward processing. | Coccurello R | β | 2019 | β |
| An Integrated Neuronal Model of Claustral Function in Timing the Synchrony Between Cortical Areas. | Vidyasagar TR et al. | β | 2019 | β |
| Bold zebrafish (Danio rerio) express higher levels of delta opioid and dopamine D2 receptors in the brain compared to shy fish. | ThΓΆrnqvist PO et al. | β | 2019 | β |
| Buprenorphine prevents stress-induced blunting of nucleus accumbens dopamine response and approach behavior to food reward in mice. | Robinson SA et al. | β | 2019 | β |
| Differential rewarding effects of electrical stimulation of the lateral hypothalamus and parabrachial complex: Functional characterization and the relevance of opioid systems and dopamine. | Simon MJ et al. | β | 2019 | β |
| Dopamine and opioid systems adaptation in alcoholism revisited: Convergent evidence from positron emission tomography and postmortem studies. | Hansson AC et al. | β | 2019 | β |
| Dopaminergic cellular and circuit contributions to kappa opioid receptor mediated aversion. | Margolis EB et al. | β | 2019 | β |
| Dynorphin/kappa-opioid receptor control of dopamine dynamics: Implications for negative affective states and psychiatric disorders. | Tejeda HA et al. | β | 2019 | β |
| Ghrelin and food reward. | Al Massadi O et al. | β | 2019 | β |
| Impact of Substance Use Disorder Pharmacotherapy on Executive Function: A Narrative Review. | Butler K et al. | β | 2019 | β |
| Kappa Opioid Receptors Drive a Tonic Aversive Component of Chronic Pain. | Liu SS et al. | β | 2019 | β |
| MP1104, a mixed kappa-delta opioid receptor agonist has anti-cocaine properties with reduced side-effects in rats. | Atigari DV et al. | β | 2019 | β |
| Opioid and nondopamine reward circuitry and state-dependent mechanisms. | Fujita M et al. | β | 2019 | β |
| Opioid-galanin receptor heteromers mediate the dopaminergic effects of opioids. | Cai NS et al. | β | 2019 | β |
| Opioid Neurobiology, Neurogenetics and Neuropharmacology in Zebrafish. | Bao W et al. | β | 2019 | β |
| Selective dopamine D3 receptor antagonist YQA14 inhibits morphine-induced behavioral sensitization in wild type, but not in dopamine D3 receptor knockout mice. | Lv Y et al. | β | 2019 | β |
| Structure and dynamics of dynorphin peptide and its receptor. | FerrΓ© G et al. | β | 2019 | β |
| The Kappa Opioid Receptor Is Associated With Naltrexone-Induced Reduction of Drinking and Craving. | de Laat B et al. | β | 2019 | β |
| The Response of Ventral Tegmental Area Dopaminergic Neurons to Bupropion: Excitation or Inhibition? | Sadighparvar S et al. | β | 2019 | β |
| The role of the neuropeptide PEN receptor, GPR83, in the reward pathway: Relationship to sex-differences. | Fakira AK et al. | β | 2019 | β |
| Anti-stress neuropharmacological mechanisms and targets for addiction treatment: A translational framework. | Greenwald MK | β | 2018 | β |
| ASAS-SSR Triennial Reproduction Symposium: Looking Back And Moving Forward-How Reproductive Physiology Has Evolved: Male reproductive behavior: sensory signaling in the brain of low-performing domestic rams. | Alexander BM | β | 2018 | β |
| Discriminative Stimulus Properties of Opioid Ligands: Progress and Future Directions. | Butelman ER et al. | β | 2018 | β |
| Dopaminergic and Opioid Pathways Associated with Impulse Control Disorders in Parkinson's Disease. | Erga AH et al. | β | 2018 | β |
| Dopamine synthesis capacity correlates with Β΅-opioid receptor availability in the human basal ganglia: A triple-tracer PET study. | Majuri J et al. | β | 2018 | β |
| Dynorphin and ΞΊ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics. | Bazov I et al. | β | 2018 | β |
| Endocannabinoid Regulation of Reward and Reinforcement through Interaction with Dopamine and Endogenous Opioid Signaling. | Wenzel JM et al. | β | 2018 | β |
| Enkephalin as a Pivotal Player in Neuroadaptations Related to Psychostimulant Addiction. | Mongi-Bragato B et al. | β | 2018 | β |
| Gender-specific association of functional <i>prodynorphin</i> 68 bp repeats with cannabis exposure in an African American cohort. | Yuferov V et al. | β | 2018 | β |
| Maladaptive behavioral regulation in alcohol dependence: Role of kappa-opioid receptors in the bed nucleus of the stria terminalis. | Erikson CM et al. | β | 2018 | β |
| Management of Opioid Addiction With Opioid Substitution Treatments: Beyond Methadone and Buprenorphine. | Noble F et al. | β | 2018 | β |
| Modulation of the central opioid system as an antidepressant target in rodent models. | McHugh KL et al. | β | 2018 | β |
| Naltrexone ameliorates functional network abnormalities in alcohol-dependent individuals. | Morris LS et al. | β | 2018 | β |
| Opioid and hypocretin neuromodulation of ventral tegmental area neuronal subpopulations. | Thomas TS et al. | β | 2018 | β |
| Opioid modulation of cognitive impairment in depression. | Jacobson ML et al. | β | 2018 | β |
| Opioid receptors: drivers to addiction? | Darcq E et al. | β | 2018 | β |
| Preclinical evaluation of the kappa-opioid receptor antagonist CERC-501 as a candidate therapeutic for alcohol use disorders. | Domi E et al. | β | 2018 | β |
| Purinergic Signaling in Neuron-Astrocyte Interactions, Circadian Rhythms, and Alcohol Use Disorder. | Lindberg D et al. | β | 2018 | β |
| The ΞΊ-opioid receptor antagonist JDTic decreases ethanol intake in alcohol-preferring AA rats. | Uhari-VÀÀnΓ€nen J et al. | β | 2018 | β |
| Untangling the complexity of opioid receptor function. | Valentino RJ et al. | β | 2018 | β |
| Anhedonia to music and mu-opioids: Evidence from the administration of naltrexone. | Mallik A et al. | β | 2017 | β |
| A role for the mu opioid receptor in the antidepressant effects of buprenorphine. | Robinson SA et al. | β | 2017 | β |
| Chronic ethanol exposure increases inhibition of optically targeted phasic dopamine release in the nucleus accumbens core and medial shell ex vivo. | Melchior JR et al. | β | 2017 | β |
| Chronic nicotine-induced changes in gene expression of delta and kappa-opioid receptors and their endogenous ligands in the mesocorticolimbic system of the rat. | Ugur M et al. | β | 2017 | β |
| Design, synthesis and biological evaluation of aminobenzyloxyarylamide derivatives as selective ΞΊ opioid receptor antagonists. | Wang J et al. | β | 2017 | β |
| Dopamine D1 and D3 Receptors Modulate Heroin-Induced Cognitive Impairment through Opponent Actions in Mice. | Zhu Y et al. | β | 2017 | β |
| Dynorphin/Kappa Opioid Receptor Signaling in Preclinical Models of Alcohol, Drug, and Food Addiction. | Karkhanis A et al. | β | 2017 | β |
| Effects of naltrexone on alcohol self-administration and craving: meta-analysis of human laboratory studies. | Hendershot CS et al. | β | 2017 | β |
| Functional ΞΌ-Opioid-Galanin Receptor Heteromers in the Ventral Tegmental Area. | Moreno E et al. | β | 2017 | β |
| Glutamate and Opioid Antagonists Modulate Dopamine Levels Evoked by Innately Attractive Male Chemosignals in the Nucleus Accumbens of Female Rats. | SΓ‘nchez-CatalΓ‘n MJ et al. | β | 2017 | β |
| Influences of social reward experience on behavioral responses to drugs of abuse: Review of shared and divergent neural plasticity mechanisms for sexual reward and drugs of abuse. | Beloate LN et al. | β | 2017 | β |
| Kappa Opioid Receptors Mediate Heterosynaptic Suppression of Hippocampal Inputs in the Rat Ventral Striatum. | Brooks JM et al. | β | 2017 | β |
| Low ΞΌ-Opioid Receptor Status in Alcohol Dependence Identified by Combined Positron Emission Tomography and Post-Mortem Brain Analysis. | Hermann D et al. | β | 2017 | β |
| Nalmefene Reduces Reward Anticipation in Alcohol Dependence: An Experimental Functional Magnetic Resonance Imaging Study. | Quelch DR et al. | β | 2017 | β |
| Opiate Drugs with Abuse Liability Hijack the Endogenous Opioid System to Disrupt Neuronal and Glial Maturation in the Central Nervous System. | Hauser KF et al. | β | 2017 | β |
| Prenatal ethanol exposure modifies locomotor activity and induces selective changes in Met-enk expression in adolescent rats. | Abate P et al. | β | 2017 | β |
| Regional differences in mu-opioid receptor-dependent modulation of basal dopamine transmission in rat striatum. | Campos-Jurado Y et al. | β | 2017 | β |
| Similarities and Differences in Neurobiology. | Chen M et al. | β | 2017 | β |
| Summary and Prospect. | Wei Z et al. | β | 2017 | β |
| The current clinical knowledge on the treatment of gambling disorder: A summary. | Hloch K et al. | β | 2017 | β |
| The new kisspeptin derivative - kissorphin (KSO) - attenuates acute hyperlocomotion and sensitization induced by ethanol and morphine in mice. | Gibula-Bruzda E et al. | β | 2017 | β |
| Alcohol addiction and the mu-opioid receptor. | Berrettini W | β | 2016 | β |
| Alcohol preference and consumption are controlled by the caudal linear nucleus in alcohol-preferring rats. | Dudek M et al. | β | 2016 | β |
| Amphetamine elevates nucleus accumbens dopamine via an action potential-dependent mechanism that is modulated by endocannabinoids. | Covey DP et al. | β | 2016 | β |
| A Trigger for Opioid Misuse: Chronic Pain and Stress Dysregulate the Mesolimbic Pathway and Kappa Opioid System. | Massaly N et al. | β | 2016 | β |
| Behavioral sensitization to ethanol: Neural basis and factors that influence its acquisition and expression. | Camarini R et al. | β | 2016 | β |
| Distinct Effects of Nalmefene on Dopamine Uptake Rates and Kappa Opioid Receptor Activity in the Nucleus Accumbens Following Chronic Intermittent Ethanol Exposure. | Rose JH et al. | β | 2016 | β |
| Driving the need to feed: Insight into the collaborative interaction between ghrelin and endocannabinoid systems in modulating brain reward systems. | Edwards A et al. | β | 2016 | β |
| Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit. | Crowley NA et al. | β | 2016 | β |
| Effects of acute aerobic exercise on neural correlates of attention and inhibition in adolescents with bipolar disorder. | Metcalfe AW et al. | β | 2016 | β |
| Effects of the ΞΊ-opioid receptor on the inhibition of 100 Hz electroacupuncture on cocaine-induced conditioned place preference. | Hou B | β | 2016 | β |
| Enkephalin is essential for the molecular and behavioral expression of cocaine sensitization. | Mongi-Bragato B et al. | β | 2016 | β |
| Minimizing Postsampling Degradation of Peptides by a Thermal Benchtop Tissue Stabilization Method. | SegerstrΓΆm L et al. | β | 2016 | β |
| Modulation of nucleus accumbens connectivity by alcohol drinking and naltrexone in alcohol-preferring rats: A manganese-enhanced magnetic resonance imaging study. | Dudek M et al. | β | 2016 | β |
| Naltrexone but Not Ketanserin Antagonizes the Subjective, Cardiovascular, and Neuroendocrine Effects of Salvinorin-A in Humans. | Maqueda AE et al. | β | 2016 | β |
| Naltrexone Prevents in Males and Attenuates in Females the Expression of Behavioral Sensitization to Ethanol Regardless of Maternal Separation. | Kawakami SE et al. | β | 2016 | β |
| Opioid antagonists block acetaldehyde-induced increments in dopamine neurons activity. | Fois GR et al. | β | 2016 | β |
| Opioid-induced Hallucinations: A Review of the Literature, Pathophysiology, Diagnosis, and Treatment. | Sivanesan E et al. | β | 2016 | β |
| Opioid neuroscience for addiction medicine: From animal models to FDA approval for alcohol addiction. | Berrettini W | β | 2016 | β |
| Probabilistic reward- and punishment-based learning in opioid addiction: Experimental and computational data. | Myers CE et al. | β | 2016 | β |
| Relative Timing Between Kappa Opioid Receptor Activation and Cocaine Determines the Impact on Reward and Dopamine Release. | Chartoff EH et al. | β | 2016 | β |
| Sensory abnormalities and pain in Parkinson disease and its modulation by treatment of motor symptoms. | Cury RG et al. | β | 2016 | β |
| Strain and cocaine-induced differential opioid gene expression may predispose Lewis but not Fischer rats to escalate cocaine self-administration. | Valenza M et al. | β | 2016 | β |
| Structure-based discovery of opioid analgesics with reduced side effects. | Manglik A et al. | β | 2016 | β |
| Supersensitive Kappa Opioid Receptors Promotes Ethanol Withdrawal-Related Behaviors and Reduce Dopamine Signaling in the Nucleus Accumbens. | Rose JH et al. | β | 2016 | β |
| Switch from excitatory to inhibitory actions of ethanol on dopamine levels after chronic exposure: Role of kappa opioid receptors. | Karkhanis AN et al. | β | 2016 | β |
| The neurobiology and addiction potential of anabolic androgenic steroids and the effects of growth hormone. | GrΓΆnbladh A et al. | β | 2016 | β |
| Aberrant mesolimbic dopamine-opiate interaction in obesity. | Tuominen L et al. | β | 2015 | β |
| A ghrelin receptor (GHS-R1A) antagonist attenuates the rewarding properties of morphine and increases opioid peptide levels in reward areas in mice. | Engel JA et al. | β | 2015 | β |
| Antagonism of ΞΊ opioid receptor in the nucleus accumbens prevents the depressive-like behaviors following prolonged morphine abstinence. | Zan GY et al. | β | 2015 | β |
| A pharmacogenetic determinant of mu-opioid receptor antagonist effects on alcohol reward and consumption: evidence from humanized mice. | Bilbao A et al. | β | 2015 | β |
| Changes in mu-opioid receptor expression and function in the mesolimbic system after long-term access to a palatable diet. | Pitman KA et al. | β | 2015 | β |
| Comparative analysis of self-injury in people with psychopathology or neurodevelopmental disorders. | Crapper L et al. | β | 2015 | β |
| Decreased [3H]naloxone Binding in the Dentate Gyrus of Cloninger Type 1 Anxiety-Prone Alcoholics: A Postmortem Whole-Hemisphere Autoradiography Study. | Laukkanen V et al. | β | 2015 | β |
| Effect of norbinaltorphimine on ββΉ-tetrahydrocannabinol (THC)-induced taste avoidance in adolescent and adult Sprague-Dawley rats. | Flax SM et al. | β | 2015 | β |
| Effects of anabolic-androgens on brain reward function. | Mhillaj E et al. | β | 2015 | β |
| Fluoxetine potentiation of methylphenidate-induced gene regulation in striatal output pathways: potential role for 5-HT1B receptor. | Van Waes V et al. | β | 2015 | β |
| Inflammatory Pain Promotes Increased Opioid Self-Administration: Role of Dysregulated Ventral Tegmental Area ΞΌ Opioid Receptors. | HipΓ³lito L et al. | β | 2015 | β |
| Inhibition of opioid systems in the hypothalamus as well as the mesolimbic area suppresses feeding behavior of mice. | Ikeda H et al. | β | 2015 | β |
| Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment. | Crowley NA et al. | β | 2015 | β |
| Key role of salsolinol in ethanol actions on dopamine neuronal activity of the posterior ventral tegmental area. | Melis M et al. | β | 2015 | β |
| Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse. | Korpi ER et al. | β | 2015 | β |
| Moderate voluntary exercise attenuates the metabolic syndrome in melanocortin-4 receptor-deficient rats showing central dopaminergic dysregulation. | Obici S et al. | β | 2015 | β |
| Nalbuphine could decrease the rewarding effect induced by tramadol in mice while enhancing its antinociceptive activity. | Abdel-Ghany R et al. | β | 2015 | β |
| Nicotine and ethanol cooperate to enhance ventral tegmental area AMPA receptor function via Ξ±6-containing nicotinic receptors. | Engle SE et al. | β | 2015 | β |
| Sex Differences in Kappa Opioid Receptor Function and Their Potential Impact on Addiction. | Chartoff EH et al. | β | 2015 | β |
| The effects of n-acetylcysteine and/or deferoxamine on manic-like behavior and brain oxidative damage in mice submitted to the paradoxal sleep deprivation model of mania. | Arent CO et al. | β | 2015 | β |
| The role of Ξ΄-opioid receptors in learning and memory underlying the development of addiction. | Klenowski P et al. | β | 2015 | β |
| Understanding opioid reward. | Fields HL et al. | β | 2015 | β |
| ΞΊ-opioid receptor as a key mediator in the regulation of appetitive 50-kHz ultrasonic vocalizations. | Hamed A et al. | β | 2015 | β |
| 15 years of genetic approaches in vivo for addiction research: Opioid receptor and peptide gene knockout in mouse models of drug abuse. | Charbogne P et al. | β | 2014 | β |
| Acute and chronic dose-response effect of methylphenidate on ventral tegmental area neurons correlated with animal behavior. | Jones Z et al. | β | 2014 | β |
| Alcohol: a stimulant activating brain stress responsive systems with persistent neuroadaptation. | Zhou Y et al. | β | 2014 | β |
| Determining pharmacological selectivity of the kappa opioid receptor antagonist LY2456302 using pupillometry as a translational biomarker in rat and human. | Rorick-Kehn LM et al. | β | 2014 | β |
| Effect of activated peripheral ΞΊ-opioid receptors on the action of nicotine and its withdrawal in nicotine-dependent rats. | Sudakov SK et al. | β | 2014 | β |
| Effects of naltrexone on neural and subjective response to alcohol in treatment-seeking alcohol-dependent patients. | Spagnolo PA et al. | β | 2014 | β |
| Effects of naltrexone plus topiramate on ethanol self-administration and tyrosine hydroxylase gene expression changes. | Navarrete F et al. | β | 2014 | β |
| Effects of the kappa opioid receptor antagonist, nor-binaltorphimine, on ethanol intake: impact of age and sex. | Morales M et al. | β | 2014 | β |
| Kappa opioid receptor activation potentiates the cocaine-induced increase in evoked dopamine release recorded in vivo in the mouse nucleus accumbens. | Ehrich JM et al. | β | 2014 | β |
| "Killing Two Birds with One Stone": Alcohol Use Reduction Interventions with Potential Efficacy in Enhancing Self-Control. | Leeman RF et al. | β | 2014 | β |
| LY2456302 is a novel, potent, orally-bioavailable small molecule kappa-selective antagonist with activity in animal models predictive of efficacy in mood and addictive disorders. | Rorick-Kehn LM et al. | β | 2014 | β |
| Modest long-term ethanol consumption affects expression of neurotransmitter receptor genes in the rat nucleus accumbens. | Jonsson S et al. | β | 2014 | β |
| Naltrexone in bipolar disorder with depression: a double-blind, placebo-controlled study. | Murphy BL et al. | β | 2014 | β |
| Pharmacogenetics of addiction therapy. | Nielsen DA et al. | β | 2014 | β |
| [Place of the opioid system in biology and treatment of Alcohol Use Disorder]. | Nubukpo P | β | 2014 | β |
| Prenatal ethanol exposure alters met-enkephalin expression in brain regions related with reinforcement: possible mechanism for ethanol consumption in offspring. | Abate P et al. | β | 2014 | β |
| Psychiatric neural networks and neuropharmacology: Selected advances and novel implications. | Ghanemi A | β | 2014 | β |
| Salvinorin A analogs and other ΞΊ-opioid receptor compounds as treatments for cocaine abuse. | Kivell BM et al. | β | 2014 | β |
| Salvinorin A regulates dopamine transporter function via a kappa opioid receptor and ERK1/2-dependent mechanism. | Kivell B et al. | β | 2014 | β |
| Stress-induced activation of ventral tegmental mu-opioid receptors reduces accumbens dopamine tone by enhancing dopamine transmission in the medial pre-frontal cortex. | Latagliata EC et al. | β | 2014 | β |
| The dopamine system and alcohol dependence. | Ma H et al. | β | 2014 | β |
| The kappa opioid receptor: from addiction to depression, and back. | Lalanne L et al. | β | 2014 | β |
| The role of the opioid system in alcohol dependence. | Nutt DJ | β | 2014 | β |
| Accumbal core: essential link in feed-forward spiraling striato-nigro-striatal in series connected loop. | Ikeda H et al. | β | 2013 | β |
| A maternal "junk-food" diet reduces sensitivity to the opioid antagonist naloxone in offspring postweaning. | Gugusheff JR et al. | β | 2013 | β |
| Analyzing Interaction of ΞΌ-, Ξ΄- and ΞΊ-opioid Receptor Gene Variants on Alcohol or Drug Dependence Using a Pattern Discovery-based Method. | Li Z et al. | β | 2013 | β |
| A systems medicine research approach for studying alcohol addiction. | Spanagel R et al. | β | 2013 | β |
| Cocaine use reduction with buprenorphine (CURB): rationale, design, and methodology. | Mooney LJ et al. | β | 2013 | β |
| Development of ΞΊ opioid receptor antagonists. | Carroll FI et al. | β | 2013 | β |
| Elucidating the biological basis for the reinforcing actions of alcohol in the mesolimbic dopamine system: the role of active metabolites of alcohol. | Deehan GA et al. | β | 2013 | β |
| Endogenous dynorphins, glutamate and N-methyl-d-aspartate (NMDA) receptors may participate in a stress-mediated Type-I auditory neural exacerbation of tinnitus. | Sahley TL et al. | β | 2013 | β |
| Involvement of dynorphin and kappa opioid receptor in yohimbine-induced reinstatement of heroin seeking in rats. | Zhou Y et al. | β | 2013 | β |
| Involvement of the endogenous opioid system in the psychopharmacological actions of ethanol: the role of acetaldehyde. | Font L et al. | β | 2013 | β |
| Kappa-opioid receptor signaling in the striatum as a potential modulator of dopamine transmission in cocaine dependence. | Trifilieff P et al. | β | 2013 | β |
| Kappa opioid receptors on dopaminergic neurons are necessary for kappa-mediated place aversion. | Chefer VI et al. | β | 2013 | β |
| Long-term ethanol effects on acute stress responses: modulation by dynorphin. | RΓ‘cz I et al. | β | 2013 | β |
| Microinjections of acetaldehyde or salsolinol into the posterior ventral tegmental area increase dopamine release in the nucleus accumbens shell. | Deehan GA et al. | β | 2013 | β |
| Neural and behavioral effects of a novel mu opioid receptor antagonist in binge-eating obese people. | Cambridge VC et al. | β | 2013 | β |
| New insights into the specificity and plasticity of reward and aversion encoding in the mesolimbic system. | Volman SF et al. | β | 2013 | β |
| Opioidergic and dopaminergic manipulation of gambling tendencies: a preliminary study in male recreational gamblers. | Porchet RI et al. | β | 2013 | β |
| Opioid pharmacogenetics of alcohol addiction. | Berrettini W | β | 2013 | β |
| Peter Riederer "70th birthday" neurobiological foundations of modern addiction treatment. | Jacob C | β | 2013 | β |
| Prefrontal cortical kappa-opioid receptor modulation of local neurotransmission and conditioned place aversion. | Tejeda HA et al. | β | 2013 | β |
| Role of kappa-opioid receptors in stress and anxiety-related behavior. | Van't Veer A et al. | β | 2013 | β |
| Salsolinol modulation of dopamine neurons. | Xie G et al. | β | 2013 | β |
| The dopamine system in mediating alcohol effects in humans. | Charlet K et al. | β | 2013 | β |
| The hormonal signature of energy deficit: Increasing the value of food reward. | Lockie SH et al. | β | 2013 | β |
| The mu/kappa agonist nalbuphine attenuates sensitization to the behavioral effects of cocaine. | Smith MA et al. | β | 2013 | β |
| The ΞΌ-opioid receptor and treatment response to naltrexone. | Thorsell A | β | 2013 | β |
| Ξ²-Arrestin 2 knockout mice exhibit sensitized dopamine release and increased reward in response to a low dose of alcohol. | BjΓΆrk K et al. | β | 2013 | β |
| ΞΊ-Opioid receptors in the central amygdala regulate ethanol actions at presynaptic GABAergic sites. | Kang-Park M et al. | β | 2013 | β |
| Acute effects of capsaicin on proopioimelanocortin mRNA levels in the arcuate nucleus of Sprague-Dawley rats. | Lee JS et al. | β | 2012 | β |
| Alcohol-induced plasticity in the dynorphin/kappa-opioid receptor system. | Sirohi S et al. | β | 2012 | β |
| An imaging genetics approach to understanding social influence. | Falk EB et al. | β | 2012 | β |
| Behavioral changes after maternal separation are reversed by chronic constant light treatment. | Dimatelis JJ et al. | β | 2012 | β |
| Cerebral interactions of pain and reward and their relevance for chronic pain. | Becker S et al. | β | 2012 | β |
| Conceptualizing withdrawal-induced escalation of alcohol self-administration as a learned, plasticity-dependent process. | Walker BM | β | 2012 | β |
| Differences in basal and ethanol-induced levels of opioid peptides in Wistar rats from five different suppliers. | Palm S et al. | β | 2012 | β |
| Dose-related behavioral, subjective, endocrine, and psychophysiological effects of the ΞΊ opioid agonist Salvinorin A in humans. | Ranganathan M et al. | β | 2012 | β |
| Dysregulation of kappa-opioid receptor systems by chronic nicotine modulate the nicotine withdrawal syndrome in an age-dependent manner. | Tejeda HA et al. | β | 2012 | β |
| Effects of oral loperamide on efficacy of naltrexone, baclofen and AM-251 in blocking ethanol self-administration in rats. | Dean RL et al. | β | 2012 | β |
| Exofocal dopaminergic degeneration as antidepressant target in mouse model of poststroke depression. | Kronenberg G et al. | β | 2012 | β |
| Feed-forward mechanisms: addiction-like behavioral and molecular adaptations in overeating. | AlsiΓΆ J et al. | β | 2012 | β |
| Fluoxetine potentiation of methylphenidate-induced neuropeptide expression in the striatum occurs selectively in direct pathway (striatonigral) neurons. | Van Waes V et al. | β | 2012 | β |
| Genetic factors modulating the response to stimulant drugs in humans. | Hart AB et al. | β | 2012 | β |
| Identification of rat ventral tegmental area GABAergic neurons. | Margolis EB et al. | β | 2012 | β |
| Increased dopamine receptor activity in the nucleus accumbens shell ameliorates anxiety during drug withdrawal. | Radke AK et al. | β | 2012 | β |
| Mice lacking Ξ΄-opioid receptors resist the development of diet-induced obesity. | Czyzyk TA et al. | β | 2012 | β |
| Neuropeptides as mediators of the early-life impact on the brain; implications for alcohol use disorders. | Nylander I et al. | β | 2012 | β |
| New vistas in opioid control of pain. | Mizoguchi H et al. | β | 2012 | β |
| Nucleus accumbens and dopamine-mediated turning behavior of the rat: role of accumbal non-dopaminergic receptors. | Ikeda H et al. | β | 2012 | β |
| On the Role of Cannabinoid CB1- and ΞΌ-Opioid Receptors in Motor Impulsivity. | Wiskerke J et al. | β | 2012 | β |
| Pain, affective symptoms, and cognitive deficits in patients with cerebral dopamine dysfunction. | Jarcho JM et al. | β | 2012 | β |
| Pathological Gambling: Neuropsychopharmacology and Treatment. | Bullock SA et al. | β | 2012 | β |
| Repeated treatment with the kappa opioid receptor agonist U69593 reverses enhanced K+ induced dopamine release in the nucleus accumbens, but not the expression of locomotor sensitization in amphetamine-sensitized rats. | Escobar Adel P et al. | β | 2012 | β |
| The dynorphin/ΞΊ-opioid receptor system and its role in psychiatric disorders. | Tejeda HA et al. | β | 2012 | β |
| The effects of lobeline and naltrexone on methamphetamine-induced place preference and striatal dopamine and serotonin levels in adolescent rats with a history of maternal separation. | Dimatelis JJ et al. | β | 2012 | β |
| The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety. | Schank JR et al. | β | 2012 | β |
| The long-lasting effects of JDTic, a kappa opioid receptor antagonist, on the expression of ethanol-seeking behavior and the relapse drinking of female alcohol-preferring (P) rats. | Deehan GA et al. | β | 2012 | β |
| The opioid system and food intake: homeostatic and hedonic mechanisms. | Nogueiras R et al. | β | 2012 | β |
| The role of parasites and pathogens in influencing generalised anxiety and predation-related fear in the mammalian central nervous system. | Kaushik M et al. | β | 2012 | β |
| Treatment of alcohol dependence with drug antagonists of the stress response. | Higley AE et al. | β | 2012 | β |
| ΞFosB enhances the rewarding effects of cocaine while reducing the pro-depressive effects of the kappa-opioid receptor agonist U50488. | Muschamp JW et al. | β | 2012 | β |
| ΞΊ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction. | Butelman ER et al. | β | 2012 | β |
| ΞΊ-Opioid receptors within the nucleus accumbens shell mediate pair bond maintenance. | Resendez SL et al. | β | 2012 | β |
| An anatomical basis for opponent process mechanisms of opiate withdrawal. | Radke AK et al. | β | 2011 | β |
| Child ΞΌ-opioid receptor gene variant influences parent-child relations. | Copeland WE et al. | β | 2011 | β |
| CNS opioid signaling separates cannabinoid receptor 1-mediated effects on body weight and mood-related behavior in mice. | Lockie SH et al. | β | 2011 | β |
| Control of striatal signaling by g protein regulators. | Xie K et al. | β | 2011 | β |
| Critical thoughts on current rodent models for evaluating potential treatments of alcohol addiction and withdrawal. | Ripley TL et al. | β | 2011 | β |
| Effects of corticotropin-releasing hormone receptor antagonists on the ethanol-induced increase of dynorphin A1-8 release in the rat central amygdala. | Lam MP et al. | β | 2011 | β |
| Inhibitory role of inducible cAMP early repressor (ICER) in methamphetamine-induced locomotor sensitization. | Han W et al. | β | 2011 | β |
| Interaction between family history of alcoholism and Locus of Control in the opioid regulation of impulsive responding under the influence of alcohol. | Altamirano LJ et al. | β | 2011 | β |
| Kappa Opioid Receptor-Mediated Disruption of Novel Object Recognition: Relevance for Psychostimulant Treatment. | Paris JJ et al. | β | 2011 | β |
| Learning and memory impairment induced by salvinorin A, the principal ingredient of Salvia divinorum, in wistar rats. | Braida D et al. | β | 2011 | β |
| Mβ muscarinic receptors mediate striatal dopamine activation by ventral tegmental morphine and pedunculopontine stimulation in mice. | Steidl S et al. | β | 2011 | β |
| Mechanistic insights into nicotine withdrawal. | Paolini M et al. | β | 2011 | β |
| Modulation of monoamine receptors by adaptor proteins and lipid rafts: role in some effects of centrally acting drugs and therapeutic agents. | BjΓΆrk K et al. | β | 2011 | β |
| Neurobiology of aversive states. | Umberg EN et al. | β | 2011 | β |
| Neuropharmacology of the naturally occurring kappa-opioid hallucinogen salvinorin A. | Cunningham CW et al. | β | 2011 | β |
| Nicotine and endogenous opioids: neurochemical and pharmacological evidence. | Hadjiconstantinou M et al. | β | 2011 | β |
| Opiate-induced dopamine release is modulated by severity of alcohol dependence: an [(18)F]fallypride positron emission tomography study. | Spreckelmeyer KN et al. | β | 2011 | β |
| OPRM1 gene variants modulate amphetamine-induced euphoria in humans. | Dlugos AM et al. | β | 2011 | β |
| Oxycodone lengthens reproductions of suprasecond time intervals in human research volunteers. | Gooch CM et al. | β | 2011 | β |
| Pharmacogenetic approaches to the treatment of alcohol addiction. | Heilig M et al. | β | 2011 | β |
| Regional mRNA expression of the endogenous opioid and dopaminergic systems in brains of C57BL/6J and 129P3/J mice: strain and heroin effects. | Schlussman SD et al. | β | 2011 | β |
| Regulation of drug and palatable food overconsumption by similar peptide systems. | Morganstern I et al. | β | 2011 | β |
| Reward, addiction, withdrawal to nicotine. | De Biasi M et al. | β | 2011 | β |
| Acute withdrawal from chronic escalating-dose binge cocaine administration alters kappa opioid receptor stimulation of [35S] guanosine 5'-O-[gamma-thio]triphosphate acid binding in the rat ventral tegmental area. | Piras AP et al. | β | 2010 | β |
| Age-dependent effects of kappa-opioid receptor stimulation on cocaine-induced stereotyped behaviors and dopamine overflow in the caudate-putamen: an in vivo microdialysis study. | Cortez AM et al. | β | 2010 | β |
| Alteration of intravenous nicotine self-administration by opioid receptor agonist and antagonists in rats. | Ismayilova N et al. | β | 2010 | β |
| Distribution and function of melanocortin receptors within the brain. | Mountjoy KG | β | 2010 | β |
| Dopamine D1 receptor gene expression decreases in the nucleus accumbens upon long-term exposure to palatable food and differs depending on diet-induced obesity phenotype in rats. | AlsiΓΆ J et al. | β | 2010 | β |
| Drug-induced and genetic alterations in stress-responsive systems: Implications for specific addictive diseases. | Zhou Y et al. | β | 2010 | β |
| Dynorphin, stress, and depression. | Knoll AT et al. | β | 2010 | β |
| Estradiol: a key biological substrate mediating the response to cocaine in female rats. | Segarra AC et al. | β | 2010 | β |
| Ethanol action on dopaminergic neurons in the ventral tegmental area: interaction with intrinsic ion channels and neurotransmitter inputs. | Morikawa H et al. | β | 2010 | β |
| Ethanol exposure selectively alters beta-endorphin content but not [3H]-DAMGO binding in discrete regions of the rat brain. | Leriche M et al. | β | 2010 | β |
| Forebrain PENK and PDYN gene expression levels in three inbred strains of mice and their relationship to genotype-dependent morphine reward sensitivity. | Gieryk A et al. | β | 2010 | β |
| Functional impact of a single-nucleotide polymorphism in the OPRD1 promoter region. | Zhang H et al. | β | 2010 | β |
| Is love passion an addictive disorder? | Reynaud M et al. | β | 2010 | β |
| Kappa opioids and the modulation of pain. | Kivell B et al. | β | 2010 | β |
| Lack of a rewarding effect and a locomotor-enhancing effect of the selective ΞΌ-opioid receptor agonist amidino-TAPA. | Mizoguchi H et al. | β | 2010 | β |
| Neurobiology of dysregulated motivational systems in drug addiction. | Edwards S et al. | β | 2010 | β |
| New horizons for therapeutics in drug and alcohol abuse. | Jupp B et al. | β | 2010 | β |
| Perinatal undernutrition facilitates morphine sensitization and cross-sensitization to cocaine in adult rats: a behavioral and neurochemical study. | Velazquez EE et al. | β | 2010 | β |
| Pharmacogenetics of alcohol and alcohol dependence treatment. | Kranzler HR et al. | β | 2010 | β |
| Postsynaptic nigrostriatal dopamine receptors and their role in movement regulation. | Korchounov A et al. | β | 2010 | β |
| Reacquisition of heroin and cocaine place preference involves a memory consolidation process sensitive to systemic and intra-ventral tegmental area naloxone. | Sticht M et al. | β | 2010 | β |
| The effects of kappa-opioid receptor ligands on prepulse inhibition and CRF-induced prepulse inhibition deficits in the rat. | Tejeda HA et al. | β | 2010 | β |
| The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse. | Wee S et al. | β | 2010 | β |
| Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues. | Heilig M et al. | β | 2010 | β |
| 30 years of dynorphins--new insights on their functions in neuropsychiatric diseases. | Schwarzer C | β | 2009 | β |
| Acute effects of morphine on distinct forms of impulsive behavior in rats. | Pattij T et al. | β | 2009 | β |
| Acute nicotine changes dynorphin and prodynorphin mRNA in the striatum. | Isola R et al. | β | 2009 | β |
| Alcoholism: a systems approach from molecular physiology to addictive behavior. | Spanagel R | β | 2009 | β |
| Altered levels of synapsin I, dopamine transporter, dynorphin A, and neuropeptide Y in the nucleus accumbens and striatum at post-puberty in rats treated neonatally with pregnenolone or DHEA. | Muneoka K et al. | β | 2009 | β |
| Biological substrates of reward and aversion: a nucleus accumbens activity hypothesis. | Carlezon WA et al. | β | 2009 | β |
| Disruption of endogenous opioid activity during instrumental learning enhances habit acquisition. | Wassum KM et al. | β | 2009 | β |
| Dopaminergic modulation of appetitive and aversive predictive learning. | Iordanova MD | β | 2009 | β |
| Effects of prodynorphin deletion on striatal dopamine in mice during normal aging and in response to MPTP. | Nguyen XV et al. | β | 2009 | β |
| Kappa-opioid ligands in the study and treatment of mood disorders. | Carlezon WA et al. | β | 2009 | β |
| kappa-Opioid receptor signaling and brain reward function. | Bruijnzeel AW | β | 2009 | β |
| Kappa-opioid system regulates the long-lasting behavioral adaptations induced by early-life exposure to methylphenidate. | Wiley MD et al. | β | 2009 | β |
| Mu opioid receptor modulation of somatodendritic dopamine overflow: GABAergic and glutamatergic mechanisms. | Chefer VI et al. | β | 2009 | β |
| Naloxone's pentapeptide binding site on filamin A blocks Mu opioid receptor-Gs coupling and CREB activation of acute morphine. | Wang HY et al. | β | 2009 | β |
| Natural products as tools for neuroscience: discovery and development of novel agents to treat drug abuse. | Prisinzano TE | β | 2009 | β |
| Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network. | Boettiger CA et al. | β | 2009 | β |
| Opioid receptors: from binding sites to visible molecules in vivo. | Kieffer BL et al. | β | 2009 | β |
| Peptide kappa opioid receptor ligands: potential for drug development. | Aldrich JV et al. | β | 2009 | β |
| Prodynorphin gene deficiency potentiates nalbuphine-induced behavioral sensitization and withdrawal syndrome in mice. | Shin EJ et al. | β | 2009 | β |
| Reward processing by the opioid system in the brain. | Le Merrer J et al. | β | 2009 | β |
| Role of the ERK/MSK1 signalling pathway in chromatin remodelling and brain responses to drugs of abuse. | Brami-Cherrier K et al. | β | 2009 | β |
| Roles of opioid receptor subtypes in mediating alcohol-seeking induced by discrete cues and context. | Marinelli PW et al. | β | 2009 | β |
| The effects of repeated opioid administration on locomotor activity: II. Unidirectional cross-sensitization to cocaine. | Smith MA et al. | β | 2009 | β |
| The role of melanin-concentrating hormone in energy homeostasis and mood disorders. | Antal-Zimanyi I et al. | β | 2009 | β |
| Tissue plasminogen activator modulates the cellular and behavioral response to cocaine. | Maiya R et al. | β | 2009 | β |
| Activation of mesolimbic dopamine neurons during novel and daily limited access to palatable food is blocked by the opioid antagonist LY255582. | Sahr AE et al. | β | 2008 | β |
| Adaptive changes in the expression of central opioid receptors in mice lacking the dopamine D2 receptor gene. | LΓ©na I et al. | β | 2008 | β |
| A possible mechanism underlying the effectiveness of acupuncture in the treatment of drug addiction. | Yang CH et al. | β | 2008 | β |
| A regulatory variation in OPRK1, the gene encoding the kappa-opioid receptor, is associated with alcohol dependence. | Edenberg HJ et al. | β | 2008 | β |
| Brain regional Fos expression elicited by the activation of mu- but not delta-opioid receptors of the ventral tegmental area: evidence for an implication of the ventral thalamus in opiate reward. | David V et al. | β | 2008 | β |
| Cloninger's typology and treatment outcome in alcohol-dependent subjects during pharmacotherapy with naltrexone. | Kiefer F et al. | β | 2008 | β |
| Delta-opioid receptor expression in the ventral tegmental area protects against elevated alcohol consumption. | Margolis EB et al. | β | 2008 | β |
| Does angiotensin interact with dopaminergic mechanisms in the brain to modulate prepulse inhibition in mice? | Martin S et al. | β | 2008 | β |
| Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intake. | Logrip ML et al. | β | 2008 | β |
| Effects of acute and repeated administration of salvinorin A on dopamine function in the rat dorsal striatum. | Gehrke BJ et al. | β | 2008 | β |
| Ethanol injected into the hypothalamic arcuate nucleus induces behavioral stimulation in rats: an effect prevented by catalase inhibition and naltrexone. | Pastor R et al. | β | 2008 | β |
| Exposure to the selective kappa-opioid receptor agonist salvinorin A modulates the behavioral and molecular effects of cocaine in rats. | Chartoff EH et al. | β | 2008 | β |
| Glycyl-glutamine reduces ethanol intake at three reward sites in P rats. | Resch GE et al. | β | 2008 | β |
| High-affinity naloxone binding to filamin a prevents mu opioid receptor-Gs coupling underlying opioid tolerance and dependence. | Wang HY et al. | β | 2008 | β |
| Long-lasting alteration in mesocorticolimbic structures after repeated social defeat stress in rats: time course of mu-opioid receptor mRNA and FosB/DeltaFosB immunoreactivity. | Nikulina EM et al. | β | 2008 | β |
| Mechanisms for the regulation of state changes in the central nervous system: an introduction. | Pfaff DW et al. | β | 2008 | β |
| Modulation of voluntary ethanol consumption by beta-arrestin 2. | BjΓΆrk K et al. | β | 2008 | β |
| Mood and neuroendocrine response to a chemical stressor, metyrapone, in buprenorphine-maintained heroin dependence. | Kakko J et al. | β | 2008 | β |
| (+)-Morphine attenuates the (-)-morphine-produced conditioned place preference and the mu-opioid receptor-mediated dopamine increase in the posterior nucleus accumbens of the rat. | Terashvili M et al. | β | 2008 | β |
| Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations. | Luo X et al. | β | 2008 | β |
| Naltrexone in the treatment of alcohol dependence. | Unterwald EM | β | 2008 | β |
| Regional adaptations in PSD-95, NGFI-A and secretogranin gene transcripts related to vulnerability to behavioral sensitization to amphetamine in the Roman rat strains. | Guitart-Masip M et al. | β | 2008 | β |
| Review. The neurobiology of pathological gambling and drug addiction: an overview and new findings. | Potenza MN | β | 2008 | β |
| Role of the dopamine transporter in the action of psychostimulants, nicotine, and other drugs of abuse. | Zhu J et al. | β | 2008 | β |
| Salvinorin A analogs as probes in opioid pharmacology. | Prisinzano TE et al. | β | 2008 | β |
| Shell/core differences in mu- and delta-opioid receptor modulation of dopamine efflux in nucleus accumbens. | HipΓ³lito L et al. | β | 2008 | β |
| Stress-induced analgesia in mice: evidence for interaction between endocannabinoids and cholecystokinin. | Kurrikoff K et al. | β | 2008 | β |
| Targeting endogenous mu- and delta-opioid receptor systems for the treatment of drug addiction. | Shippenberg TS et al. | β | 2008 | β |
| The effects of local perfusion of DAMGO on extracellular GABA and glutamate concentrations in the rostral ventromedial medulla. | Schepers RJ et al. | β | 2008 | β |
| The impact of postnatal environment on opioid peptides in young and adult male Wistar rats. | Gustafsson L et al. | β | 2008 | β |
| Translational studies of alcoholism: bridging the gap. | Zahr NM et al. | β | 2008 | β |
| U-69593, a kappa opioid receptor agonist, decreases cocaine-induced behavioral sensitization in female rats. | Puig-Ramos A et al. | β | 2008 | β |
| Update on neuropharmacological treatments for alcoholism: scientific basis and clinical findings. | Johnson BA | β | 2008 | β |
| A role for mu opioid receptors in cocaine-induced activity, sensitization, and reward in the rat. | Schroeder JA et al. | β | 2007 | β |
| Co-localization of GABA with other neuroactive substances in the basal ganglia. | McGinty JF | β | 2007 | β |
| Cotreatment with the kappa opioid agonist U69593 enhances locomotor sensitization to the D2/D3 dopamine agonist quinpirole and alters dopamine D2 receptor and prodynorphin mRNA expression in rats. | Perreault ML et al. | β | 2007 | β |
| Downregulation of kappa-opioid receptors in basolateral amygdala and septum of rats withdrawn for 14 days from an escalating dose "binge" cocaine administration paradigm. | Bailey A et al. | β | 2007 | β |
| Dynorphin and the pathophysiology of drug addiction. | Shippenberg TS et al. | β | 2007 | β |
| Dynorphin displaces binding at the glycine site of the NMDA receptor in the rat striatum. | Voorn P et al. | β | 2007 | β |
| Effects of kappa opioid receptor agonists on attention as assessed by a 5-choice serial reaction time task in rats. | Shannon HE et al. | β | 2007 | β |
| Endogenous opioid blockade and impulsive responding in alcoholics and healthy controls. | Mitchell JM et al. | β | 2007 | β |
| Enzymatic conversion of dynorphin A in the rat brain is affected by administration of nandrolone decanoate. | Magnusson K et al. | β | 2007 | β |
| Ethanol alters the effect of kappa receptor ligands on dopamine release in the nucleus accumbens. | Lindholm S et al. | β | 2007 | β |
| Ethanol-induced effects on opioid peptides in adult male Wistar rats are dependent on early environmental factors. | Gustafsson L et al. | β | 2007 | β |
| Increased locomotor response to amphetamine induced by the repeated administration of the selective kappa-opioid receptor agonist U-69593. | Fuentealba JA et al. | β | 2007 | β |
| Increased rewarding properties of morphine in perinatally protein-malnourished rats. | Valdomero A et al. | β | 2007 | β |
| Involvement of kappa opioid receptors in formalin-induced inhibition of analgesic tolerance to morphine in mice. | Tokuyama S et al. | β | 2007 | β |
| Learned preferences induced by electrical stimulation of a food-related area of the parabrachial complex: effects of naloxone. | Simon MJ et al. | β | 2007 | β |
| Mu (mu) opioid receptor regulation of ethanol-induced dopamine response in the ventral striatum: evidence of genotype specific sexual dimorphic epistasis. | Job MO et al. | β | 2007 | β |
| Nalfurafine, the kappa opioid agonist, inhibits icilin-induced wet-dog shakes in rats and antagonizes glutamate release in the dorsal striatum. | Werkheiser JL et al. | β | 2007 | β |
| Naloxone attenuates incubated sucrose craving in rats. | Grimm JW et al. | β | 2007 | β |
| Placebo effects on human mu-opioid activity during pain. | Wager TD et al. | β | 2007 | β |
| Preprodynorphin mediates locomotion and D2 dopamine and mu-opioid receptor changes induced by chronic 'binge' cocaine administration. | Bailey A et al. | β | 2007 | β |
| Presence of pro-opiomelanocortin mRNA in the rat medial prefrontal cortex, nucleus accumbens and ventral tegmental area: studies by RT-PCR and in situ hybridization techniques. | Leriche M et al. | β | 2007 | β |
| Psychotropic analgesic nitrous oxide for alcoholic withdrawal states. | Gillman MA et al. | β | 2007 | β |
| Reinstatement of cocaine place-conditioning prevented by the peptide kappa-opioid receptor antagonist arodyn. | Carey AN et al. | β | 2007 | β |
| Role of mu-opioid receptor in modulation of preproenkephalin mRNA expression and opioid and dopamine receptor binding in methamphetamine-sensitized mice. | Tien LT et al. | β | 2007 | β |
| Supersensitivity to amphetamine in protein kinase-C interacting protein/HINT1 knockout mice. | Barbier E et al. | β | 2007 | β |
| The contribution of endogenous opioids to food reward is dependent on sex and background strain. | Hayward MD et al. | β | 2007 | β |
| The endomorphin system and its evolving neurophysiological role. | Fichna J et al. | β | 2007 | β |
| The opioid system in alcohol and drug dependence: family-based association study. | Xuei X et al. | β | 2007 | β |
| Ventral tegmental area neurons in learned appetitive behavior and positive reinforcement. | Fields HL et al. | β | 2007 | β |
| A microdialysis profile of dynorphin A(1-8) release in the rat nucleus accumbens following alcohol administration. | Marinelli PW et al. | β | 2006 | β |
| Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence. | Zhang H et al. | β | 2006 | β |
| Attenuation of morphine tolerance and withdrawal syndrome by coadministration of nalbuphine. | Jang S et al. | β | 2006 | β |
| Depressive-like effects of the kappa-opioid receptor agonist salvinorin A on behavior and neurochemistry in rats. | Carlezon WA et al. | β | 2006 | β |
| Differential effects of naltrexone on cardiac, subjective and behavioural reactions to acute ethanol intoxication. | Peterson JB et al. | β | 2006 | β |
| Effects of the selective delta opioid agonist SNC80 on cocaine- and food-maintained responding in rhesus monkeys. | Do Carmo GP et al. | β | 2006 | β |
| Endogenous kappa opioid receptor systems modulate the responsiveness of mesoaccumbal dopamine neurons to ethanol. | Zapata A et al. | β | 2006 | β |
| From Malthus to motive: how the HPA axis engineers the phenotype, yoking needs to wants. | Pecoraro N et al. | β | 2006 | β |
| Kappa-opioid agonist U69593 potentiates locomotor sensitization to the D2/D3 agonist quinpirole: pre- and postsynaptic mechanisms. | Perreault ML et al. | β | 2006 | β |
| Kappa-opioid receptor modulation of accumbal dopamine concentration during operant ethanol self-administration. | Doyon WM et al. | β | 2006 | β |
| Kappa opioids selectively control dopaminergic neurons projecting to the prefrontal cortex. | Margolis EB et al. | β | 2006 | β |
| Melanin-concentrating hormone MCH1 receptor antagonists: a potential new approach to the treatment of depression and anxiety disorders. | Shimazaki T et al. | β | 2006 | β |
| Methamphetamine-induced behavioral sensitization in mice: alterations in mu-opioid receptor. | Chiu CT et al. | β | 2006 | β |
| Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application. | Millan MJ | β | 2006 | β |
| Nalbuphine is effective in decreasing the rewarding effect induced by morphine in rats. | Tao PL et al. | β | 2006 | β |
| Naltrexone and buprenorphine combination in the treatment of opioid dependence. | Gerra G et al. | β | 2006 | β |
| Neurochemistry of the nucleus accumbens and its relevance to depression and antidepressant action in rodents. | Shirayama Y et al. | β | 2006 | β |
| Opioid receptors in the nucleus accumbens regulate attentional learning in the blocking paradigm. | Iordanova MD et al. | β | 2006 | β |
| Paradoxical effects of prodynorphin gene deletion on basal and cocaine-evoked dopaminergic neurotransmission in the nucleus accumbens. | Chefer VI et al. | β | 2006 | β |
| Reduced psychostimulant effects on dopamine dynamics in the nucleus accumbens of mu-opioid receptor knockout mice. | Mathon DS et al. | β | 2006 | β |
| Repeated administration of the selective kappa-opioid receptor agonist U-69593 increases stimulated dopamine extracellular levels in the rat nucleus accumbens. | Fuentealba JA et al. | β | 2006 | β |
| Running has differential effects on NPY, opiates, and cell proliferation in an animal model of depression and controls. | BjΓΈrnebekk A et al. | β | 2006 | β |
| Social defeat stress-induced behavioral responses are mediated by the endogenous kappa opioid system. | McLaughlin JP et al. | β | 2006 | β |
| The alcohol-preferring AA and alcohol-avoiding ANA rats: neurobiology of the regulation of alcohol drinking. | Sommer W et al. | β | 2006 | β |
| The mesolimbic dopamine system: the final common pathway for the reinforcing effect of drugs of abuse? | Pierce RC et al. | β | 2006 | β |
| The role of opioid receptor subtypes in the development of behavioral sensitization to ethanol. | Pastor R et al. | β | 2006 | β |
| Variations in opioid peptide levels during the estrous cycle in Sprague-Dawley rats. | Roman E et al. | β | 2006 | β |
| Addiction: a disease of learning and memory. | Hyman SE | β | 2005 | β |
| A single injection of the kappa opioid antagonist norbinaltorphimine increases ethanol consumption in rats. | Mitchell JM et al. | β | 2005 | β |
| Blockade of stimulant-induced preprodynorphin mRNA expression in the striatal matrix by serotonin depletion. | Horner KA et al. | β | 2005 | β |
| Characterization of a novel bivalent morphinan possessing kappa agonist and micro agonist/antagonist properties. | Mathews JL et al. | β | 2005 | β |
| Chronic corticotropin-releasing factor type 1 receptor antagonism with antalarmin regulates the dopaminergic system of Fawn-Hooded rats. | Lawrence AJ et al. | β | 2005 | β |
| Clorazepate affects cell surface regulation of delta and kappa opioid receptors, thereby altering buprenorphine-induced adaptation in the rat brain. | Quentin T et al. | β | 2005 | β |
| Comparison of basal and D-1 dopamine receptor agonist-stimulated neuropeptide gene expression in caudate-putamen and nucleus accumbens of ad libitum fed and food-restricted rats. | Haberny SL et al. | β | 2005 | β |
| Direct evidence for the involvement of the mesolimbic kappa-opioid system in the morphine-induced rewarding effect under an inflammatory pain-like state. | Narita M et al. | β | 2005 | β |
| Effects of the plant-derived hallucinogen salvinorin A on basal dopamine levels in the caudate putamen and in a conditioned place aversion assay in mice: agonist actions at kappa opioid receptors. | Zhang Y et al. | β | 2005 | β |
| Endogenous kappa-opioid receptor systems regulate mesoaccumbal dopamine dynamics and vulnerability to cocaine. | Chefer VI et al. | β | 2005 | β |
| Ethanol-induced conditioned place preference is expressed through a ventral tegmental area dependent mechanism. | Bechtholt AJ et al. | β | 2005 | β |
| Ginsenosides attenuate methamphetamine-induced behavioral side effects in mice via activation of adenosine A2A receptors: possible involvements of the striatal reduction in AP-1 DNA binding activity and proenkephalin gene expression. | Shin EJ et al. | β | 2005 | β |
| Immediate withdrawal from chronic "binge" cocaine administration increases mu-opioid receptor mRNA levels in rat frontal cortex. | Bailey A et al. | β | 2005 | β |
| Increased gabaergic input to ventral tegmental area dopaminergic neurons associated with decreased cocaine reinforcement in mu-opioid receptor knockout mice. | Mathon DS et al. | β | 2005 | β |
| Interactions among mu- and delta-opioid receptors, especially putative delta1- and delta2-opioid receptors, promote dopamine release in the nucleus accumbens. | Hirose N et al. | β | 2005 | β |
| Interface of physical and emotional stress regulation through the endogenous opioid system and mu-opioid receptors. | Ribeiro SC et al. | β | 2005 | β |
| Kappa opioid receptor activation disrupts prepulse inhibition of the acoustic startle in rats. | Bortolato M et al. | β | 2005 | β |
| Kappa opioids as potential treatments for stimulant dependence. | Prisinzano TE et al. | β | 2005 | β |
| Kappa opioids inhibit physiologically identified medullary pain modulating neurons and reduce morphine antinociception. | Meng ID et al. | β | 2005 | β |
| Naloxone's suppression of spontaneous and food-conditioned locomotor activity is diminished in mice lacking either the dopamine D(2) receptor or enkephalin. | Hayward MD et al. | β | 2005 | β |
| Parsing molecular and behavioral effects of cocaine in mitogen- and stress-activated protein kinase-1-deficient mice. | Brami-Cherrier K et al. | β | 2005 | β |
| Pathobiology of dynorphins in trauma and disease. | Hauser KF et al. | β | 2005 | β |
| Prefrontal GABA levels in cocaine-dependent subjects increase with pramipexole and venlafaxine treatment. | Streeter CC et al. | β | 2005 | β |
| Prolonged effects of repeated social defeat stress on mRNA expression and function of mu-opioid receptors in the ventral tegmental area of rats. | Nikulina EM et al. | β | 2005 | β |
| The contribution of genetics to addiction therapy approaches. | Edenberg HJ et al. | β | 2005 | β |
| The development of tolerance to locomotor effects of morphine and the effect of various opioid receptor antagonists in rats chronically treated with morphine. | TimΓ‘r J et al. | β | 2005 | β |
| The kappa opioid agonist U50,488 potentiates 6-hydroxydopamine-induced neurotoxicity on dopaminergic neurons. | Marin C et al. | β | 2005 | β |
| 10-Ketomorphinan and 3-substituted-3-desoxymorphinan analogues as mixed kappa and micro opioid ligands: synthesis and biological evaluation of their binding affinity at opioid receptors. | Zhang A et al. | β | 2004 | β |
| [3H]DPDPE binding to delta opioid receptors in the rat mesocorticolimbic and nigrostriatal pathways is transiently increased by acute ethanol administration. | MΓ©ndez M et al. | β | 2004 | β |
| A single cocaine exposure enhances both opioid reward and aversion through a ventral tegmental area-dependent mechanism. | Kim JA et al. | β | 2004 | β |
| Buprenorphine: a unique drug with complex pharmacology. | Lutfy K et al. | β | 2004 | β |
| Contrasting effects of mu opioid receptor and delta opioid receptor deletion upon the behavioral and neurochemical effects of cocaine. | Chefer VI et al. | β | 2004 | β |
| Deltorphin II enhances extracellular levels of dopamine in the nucleus accumbens via opioid receptor-independent mechanisms. | Murakawa K et al. | β | 2004 | β |
| Effect of the combination of naltrexone and acamprosate on alcohol intake in mice. | Kim SG et al. | β | 2004 | β |
| Effect of the endogenous kappa opioid agonist dynorphin A(1-17) on cocaine-evoked increases in striatal dopamine levels and cocaine-induced place preference in C57BL/6J mice. | Zhang Y et al. | β | 2004 | β |
| Endogenous opioids mediate basal hedonic tone independent of dopamine D-1 or D-2 receptor activation. | Narayanan S et al. | β | 2004 | β |
| fMRI measurement of CNS responses to naloxone infusion and subsequent mild noxious thermal stimuli in healthy volunteers. | Borras MC et al. | β | 2004 | β |
| Frontal lobe GABA levels in cocaine dependence: a two-dimensional, J-resolved magnetic resonance spectroscopy study. | Ke Y et al. | β | 2004 | β |
| Imaging localised dynamic changes in the nucleus accumbens following nicotine withdrawal in rats. | Shoaib M et al. | β | 2004 | β |
| Molecular neurobiology of drug addiction. | Chao J et al. | β | 2004 | β |
| Morphine-induced c-fos mRNA expression in striatofugal circuits: modulation by dose, environmental context, and drug history. | Ferguson SM et al. | β | 2004 | β |
| Opiate-like effects of sugar on gene expression in reward areas of the rat brain. | Spangler R et al. | β | 2004 | β |
| Opposite effects of gamma(1)- and gamma(2)-melanocyte stimulating hormone on regulation of the dopaminergic mesolimbic system in rats. | Jansone B et al. | β | 2004 | β |
| Orphanin FQ/nociceptin suppresses motor activity through an action along the mesoaccumbens axis in rats. | Narayanan S et al. | β | 2004 | β |
| Pharmacogenetic insights to monoaminergic dysfunction in alcohol dependence. | Heinz A et al. | β | 2004 | β |
| Quantitative autoradiography of dopamine receptors in the brains of micro-opioid receptor knockout mice. | LΓ©na I et al. | β | 2004 | β |
| Repeated exposure to social stress has long-term effects on indirect markers of dopaminergic activity in brain regions associated with motivated behavior. | Lucas LR et al. | β | 2004 | β |
| Role of mu- and delta-opioid receptors in the nucleus accumbens in turning behaviour of rats. | Matsuzaki S et al. | β | 2004 | β |
| Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects. | Shirayama Y et al. | β | 2004 | β |
| Acute 'binge' cocaine administration elevates dynorphin mRNA in the caudate putamen of C57BL/6J but not 129/J mice. | Schlussman SD et al. | β | 2003 | β |
| Basal and morphine-evoked dopaminergic neurotransmission in the nucleus accumbens of MOR- and DOR-knockout mice. | Chefer VI et al. | β | 2003 | β |
| "Binge" cocaine differentially alters preproenkephalin mRNA levels in guinea pig brain. | LaForge KS et al. | β | 2003 | β |
| Effect of acute and chronic administration of U50,488, a kappa opioid receptor agonist, in 6-OHDA-lesioned rats chronically treated with levodopa. | Marin C et al. | β | 2003 | β |
| Effects of single and dual administration of cocaine and ethanol on opioid and ORL1 receptor expression in rat CNS: an autoradiographic study. | Rosin A et al. | β | 2003 | β |
| Effects of the opioid antagonist naltrexone on feeding induced by DAMGO in the ventral tegmental area and in the nucleus accumbens shell region in the rat. | MacDonald AF et al. | β | 2003 | β |
| Elevated D3 dopamine receptor mRNA in dopaminergic and dopaminoceptive regions of the rat brain in response to morphine. | Spangler R et al. | β | 2003 | β |
| Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice. | Bohn LM et al. | β | 2003 | β |
| Kappa-opioid agonists directly inhibit midbrain dopaminergic neurons. | Margolis EB et al. | β | 2003 | β |
| Kappa opioid receptor activation in the nucleus accumbens inhibits glutamate and GABA release through different mechanisms. | Hjelmstad GO et al. | β | 2003 | β |
| Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses. | McLaughlin JP et al. | β | 2003 | β |
| Lack of effect of kappa-opioid receptor agonism on long-term methamphetamine-induced neurotoxicity in rats. | Johnson-Davis KL et al. | β | 2003 | β |
| Local mu and delta opioid receptors regulate amphetamine-induced behavior and neuropeptide mRNA in the striatum. | Gonzalez-Nicolini MV et al. | β | 2003 | β |
| Long-term effects of maternal separation on ethanol intake and brain opioid and dopamine receptors in male Wistar rats. | Ploj K et al. | β | 2003 | β |
| Neonatal administration of monosodium glutamate prevents the development of ethanol- but not psychostimulant-induced sensitization: a putative role of the arcuate nucleus. | Miquel M et al. | β | 2003 | β |
| Region selective up-regulation of micro-, delta- and kappa-opioid receptors but not opioid receptor-like 1 receptors in the brains of enkephalin and dynorphin knockout mice. | Clarke S et al. | β | 2003 | β |
| Reward craving and withdrawal relief craving: assessment of different motivational pathways to alcohol intake. | Heinz A et al. | β | 2003 | β |
| Ultra-long antagonism of kappa opioid agonist-induced diuresis by intracisternal nor-binaltorphimine in monkeys. | Ko MC et al. | β | 2003 | β |
| Vivitrex, an injectable, extended-release formulation of naltrexone, provides pharmacokinetic and pharmacodynamic evidence of efficacy for 1 month in rats. | Bartus RT et al. | β | 2003 | β |
| 8-Carboxamidocyclazocine: a long-acting, novel benzomorphan. | Bidlack JM et al. | β | 2002 | β |
| Dopaminergic dysfunction in alcoholism and schizophrenia--psychopathological and behavioral correlates. | Heinz A | β | 2002 | β |
| Effects of melanocortin receptor ligands on ethanol intake and opioid peptide levels in alcohol-preferring AA rats. | Ploj K et al. | β | 2002 | β |
| Endomorphin-1 and -2 immunoreactive cells in the hypothalamus are labeled by fluoro-gold injections to the ventral tegmental area. | Greenwell TN et al. | β | 2002 | β |
| Estrogen and opioids interact to modulate the locomotor response to cocaine in the female rat. | Febo M et al. | β | 2002 | β |
| Exploring the opioid system by gene knockout. | Kieffer BL et al. | β | 2002 | β |
| Injection of substance P (SP) N-terminal fragment SP(1-7) into the ventral tegmental area modulates the levels of nucleus accumbens dopamine and dihydroxyphenylacetic acid in male rats during morphine withdrawal. | Zhou Q et al. | β | 2002 | β |
| Interaction between neuropeptide FF and opioids in the ventral tegmental area in the behavioral response to novelty. | Cador M et al. | β | 2002 | β |
| mu/delta Cooperativity and opposing kappa-opioid effects in nucleus accumbens-mediated antinociception in the rat. | Schmidt BL et al. | β | 2002 | β |
| Orphanin FQ/nociceptin but not Ro 65-6570 inhibits the expression of cocaine-induced conditioned place preference. | KotliΕska J et al. | β | 2002 | β |
| Paradoxical locomotor activating effects of kappa-opioid receptor stimulation in the preweanling rat: role of the ventromedial thalamus and superior colliculus. | Zavala AR et al. | β | 2002 | β |
| Peripheral electric stimulation attenuates the expression of cocaine-induced place preference in rats. | Ren YH et al. | β | 2002 | β |
| Pharmacotherapy of addictions. | Kreek MJ et al. | β | 2002 | β |
| Running increases ethanol preference. | Werme M et al. | β | 2002 | β |
| Stimulus-induced craving and startle potentiation in abstinent alcoholics and controls. | GrΓΌsser SM et al. | β | 2002 | β |
| Structure of Met-enkephalin in explicit aqueous solution using replica exchange molecular dynamics. | Sanbonmatsu KY et al. | β | 2002 | β |
| The effect of chronic ethanol consumption and withdrawal on mu-opioid and dopamine D(1) and D(2) receptor density in Fawn-Hooded rat brain. | Djouma E et al. | β | 2002 | β |
| Ultrastructural localization of enkephalin and mu-opioid receptors in the rat ventral tegmental area. | GarzΓ³n M et al. | β | 2002 | β |
| A concept of welfare based on reward evaluating mechanisms in the brain: anticipatory behaviour as an indicator for the state of reward systems. | Spruijt BM et al. | β | 2001 | β |
| Acute ethanol administration differentially modulates mu opioid receptors in the rat meso-accumbens and mesocortical pathways. | MΓ©ndez M et al. | β | 2001 | β |
| Addiction and the brain: the neurobiology of compulsion and its persistence. | Hyman SE et al. | β | 2001 | β |
| Autoradiographic mapping of the opioid receptor-like 1 (ORL1) receptor in the brains of mu-, delta- or kappa-opioid receptor knockout mice. | Slowe SJ et al. | β | 2001 | β |
| Biphasic dose-related effects of morphine on dopamine release. | Maisonneuve IM et al. | β | 2001 | β |
| Cellular and synaptic adaptations mediating opioid dependence. | Williams JT et al. | β | 2001 | β |
| Differential effects of endomorphin-1 and -2 on amphetamine sensitization: neurochemical and behavioral aspects. | Chen JC et al. | β | 2001 | β |
| Different motivational effects induced by the endogenous mu-opioid receptor ligands endomorphin-1 and -2 in the mouse. | Narita M et al. | β | 2001 | β |
| Elevation of guinea pig brain preprodynorphin mRNA expression and hypothalamic-pituitary-adrenal axis activity by "binge" pattern cocaine administration. | Yuferov V et al. | β | 2001 | β |
| Endomorphin1-like immunoreactivity in the limbic system of Syrian hamsters (Mesocricetus auratus). | Whitten RD et al. | β | 2001 | β |
| Ethanol administration potentiates cocaine-induced dopamine levels in the rat nucleus accumbens. | Lindholm S et al. | β | 2001 | β |
| Influence of the endogenous opioid system on high alcohol consumption and genetic predisposition to alcoholism. | Gianoulakis C | β | 2001 | β |
| Kappa opioid receptor inhibition of glutamatergic transmission in the nucleus accumbens shell. | Hjelmstad GO et al. | β | 2001 | β |
| Kappa opioid receptor stimulation decreases amphetamine-induced behavior and neuropeptide mRNA expression in the striatum. | Tzaferis JA et al. | β | 2001 | β |
| Major coexpression of kappa-opioid receptors and the dopamine transporter in nucleus accumbens axonal profiles. | Svingos AL et al. | β | 2001 | β |
| Modulation of pre- and postsynaptic dopamine D2 receptor function by the selective kappa-opioid receptor agonist U69593. | Acri JB et al. | β | 2001 | β |
| Modulation of the behavioral and neurochemical effects of psychostimulants by kappa-opioid receptor systems. | Shippenberg TS et al. | β | 2001 | β |
| Naltrexone suppresses ethanol intake in 6-hydroxydopamine-treated rats. | Koistinen M et al. | β | 2001 | β |
| Orphanin FQ/nociceptin attenuates motor stimulation and changes in nucleus accumbens extracellular dopamine induced by cocaine in rats. | Lutfy K et al. | β | 2001 | β |
| Reduction of opioid dependence by the CB(1) antagonist SR141716A in mice: evaluation of the interest in pharmacotherapy of opioid addiction. | Mas-Nieto M et al. | β | 2001 | β |
| Regulation of opioid receptors by cocaine. | Unterwald EM | β | 2001 | β |
| The selective kappa-opioid receptor agonist U50,488H attenuates voluntary ethanol intake in the rat. | Lindholm S et al. | β | 2001 | β |
| Addiction, dopamine, and the molecular mechanisms of memory. | Berke JD et al. | β | 2000 | β |
| Anabolic androgenic steroids affects alcohol intake, defensive behaviors and brain opioid peptides in the rat. | Johansson P et al. | β | 2000 | β |
| Basal and cocaine-induced opioid receptor gene expression in the rat CNS analyzed by competitive reverse transcription PCR. | Rosin A et al. | β | 2000 | β |
| Basal levels and alcohol-induced changes in nociceptin/orphanin FQ, dynorphin, and enkephalin levels in C57BL/6J mice. | Ploj K et al. | β | 2000 | β |
| Concurrent modulation of anxiety and memory. | Wall PM et al. | β | 2000 | β |
| Effects of differential modulation of mu-, delta- and kappa-opioid systems on bicuculline-induced convulsions in the mouse. | Yajima Y et al. | β | 2000 | β |
| Effects of naltrexone on the accumulation of L-3, 4-dihydroxyphenylalanine and 5-hydroxy-L-tryptophan and on the firing rate induced by acute ethanol administration. | Inoue H | β | 2000 | β |
| Interactions between kappa opioid agonists and cocaine. Preclinical studies. | Mello NK et al. | β | 2000 | β |
| Kappa opioid agonists as targets for pharmacotherapies in cocaine abuse. | Neumeyer JL et al. | β | 2000 | β |
| Kappa-opioid receptor activation modifies dopamine uptake in the nucleus accumbens and opposes the effects of cocaine. | Thompson AC et al. | β | 2000 | β |
| Kappa-opioid receptor modulation of nicotine-induced behaviour. | Hahn B et al. | β | 2000 | β |
| kappa-Opioid receptors in the substantia nigra pars reticulata mediate the U-50,488-induced locomotor activity of preweanling rats. | Collins RL et al. | β | 2000 | β |
| Naltrexone treatment for a 3-year-old boy with self-injurious behavior. | White T et al. | β | 2000 | β |
| Neutral endopeptidase and alcohol consumption, experiments in neutral endopeptidase-deficient mice. | Siems W et al. | β | 2000 | β |
| Nociceptin differentially affects morphine-induced dopamine release from the nucleus accumbens and nucleus caudate in rats. | Di Giannuario A et al. | β | 2000 | β |
| Patterns of response to acute naloxone infusion in Tourette's syndrome. | van Wattum PJ et al. | β | 2000 | β |
| Repeated ethanol administration induces short- and long-term changes in enkephalin and dynorphin tissue concentrations in rat brain. | Lindholm S et al. | β | 2000 | β |
| Running and cocaine both upregulate dynorphin mRNA in medial caudate putamen. | Werme M et al. | β | 2000 | β |
| Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine dependence. | Neumeyer JL et al. | β | 2000 | β |
| Synthesis of enantiomerically pure (+)- and (-)-18-methoxycoronaridine hydrochloride and their preliminary assessment as anti-addictive agents. | King CH et al. | β | 2000 | β |
| The effect on opioid peptides in the rat brain, after chronic treatment with the anabolic androgenic steroid, nandrolone decanoate. | Johansson P et al. | β | 2000 | β |
| The potential anti-addictive agent, 18-methoxycoronaridine, blocks the sensitized locomotor and dopamine responses produced by repeated morphine treatment. | Szumlinski KK et al. | β | 2000 | β |
| U-69,593 microinjection in the infralimbic cortex reduces anxiety and enhances spontaneous alternation memory in mice. | Wall PM et al. | β | 2000 | β |
| Acute subjective effects of dynorphin A(1-13) infusion in normal healthy subjects. | King AC et al. | β | 1999 | β |
| Cellular sites for dynorphin activation of kappa-opioid receptors in the rat nucleus accumbens shell. | Svingos AL et al. | β | 1999 | β |
| Central administration of an opiate antagonist decreases oral ethanol self-administration in rats. | Heyser CJ et al. | β | 1999 | β |
| Chronic morphine exposure and spontaneous withdrawal are associated with modifications of dopamine receptor and neuropeptide gene expression in the rat striatum. | Georges F et al. | β | 1999 | β |
| Comparison of the proopiomelanocortin and proenkephalin opioid peptide systems in brain regions of the alcohol-preferring C57BL/6 and alcohol-avoiding DBA/2 mice. | Jamensky NT et al. | β | 1999 | β |
| (+/-)Cyclazocine blocks the dopamine response to nicotine. | Maisonneuve IM et al. | β | 1999 | β |
| D3 dopamine and kappa opioid receptor alterations in human brain of cocaine-overdose victims. | Mash DC et al. | β | 1999 | β |
| Differential effects of mu and kappa opioid antagonists on Fos-like immunoreactivity in extended amygdala. | Carr KD et al. | β | 1999 | β |
| Downregulation of kappa opioid receptor mRNA levels by chronic ethanol and repetitive cocaine in rat ventral tegmentum and nucleus accumbens. | Rosin A et al. | β | 1999 | β |
| Expression of mu, kappa, and delta opioid receptor messenger RNA in the human CNS: a 33P in situ hybridization study. | Peckys D et al. | β | 1999 | β |
| Fentanyl increases dopamine release in rat nucleus accumbens: involvement of mesolimbic mu- and delta-2-opioid receptors. | Yoshida Y et al. | β | 1999 | β |
| Indirect dopamine agonists augment the locomotor activating effects of the kappa-opioid receptor agonist U-50,488 in preweanling rats. | McDougall SA et al. | β | 1999 | β |
| kappa-Opioid tolerance and dependence in cultures of dopaminergic midbrain neurons. | Dalman FC et al. | β | 1999 | β |
| Locomotor-activity-induced changes in striatal levels of preprotachykinin and preproenkephalin mRNA. Regulation by the dopaminergic and glutamatergic systems. | Liste I et al. | β | 1999 | β |
| Long-lasting sensitization towards morphine in motoric and limbic areas as determined by c-fos expression in rat brain. | Erdtmann-Vourliotis M et al. | β | 1999 | β |
| Naltrexone affects cocaine self-administration in naΓ―ve rats through the ventral tegmental area rather than dopaminergic target regions. | Ramsey NF et al. | β | 1999 | β |
| Nicotine self-administration in animals as a dependence model. | Corrigall WA | β | 1999 | β |
| Orphanin FQ and behavioral sensitization to cocaine. | Narayanan S et al. | β | 1999 | β |
| Orphanin FQ/nociceptin modulation of mesolimbic dopamine transmission determined by microdialysis. | Murphy NP et al. | β | 1999 | β |
| Pharmacotherapies for treatment of cocaine abuse: preclinical aspects. | Carroll FI et al. | β | 1999 | β |
| Quantitative autoradiography of mu-,delta- and kappa1 opioid receptors in kappa-opioid receptor knockout mice. | Slowe SJ et al. | β | 1999 | β |
| Regulation of neurotransmitter interactions in the ventral striatum. | McGinty JF | β | 1999 | β |
| Targeted mutagenesis of the murine opioid system. | Hayward MD et al. | β | 1999 | β |
| The dopamine hypothesis of reward: past and current status. | Spanagel R et al. | β | 1999 | β |
| The kappa-opioid agonist, U-69593, decreases acute amphetamine-evoked behaviors and calcium-dependent dialysate levels of dopamine and glutamate in the ventral striatum. | Gray AM et al. | β | 1999 | β |
| What peptides these deltorphins be. | Lazarus LH et al. | β | 1999 | β |
| A dopamine-mu1 opioid link in the rat ventral tegmentum shared by palatable food (Fonzies) and non-psychostimulant drugs of abuse. | Tanda G et al. | β | 1998 | β |
| Alcohol-seeking behavior: the roles of the hypothalamic-pituitary-adrenal axis and the endogenous opioid system. | Gianoulakis C | β | 1998 | β |
| Association of alcohol or other drug dependence with alleles of the mu opioid receptor gene (OPRM1). | Kranzler HR et al. | β | 1998 | β |
| Clinical role and mechanisms of action of analgesic nitrous oxide. | Gillman MA et al. | β | 1998 | β |
| Comparison of mesocorticolimbic neuronal responses during cocaine and heroin self-administration in freely moving rats. | Chang JY et al. | β | 1998 | β |
| Differences in the kappa opioid receptor mRNA content in distinct brain regions of two inbred mice strains. | Winkler A et al. | β | 1998 | β |
| Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal. | Simonin F et al. | β | 1998 | β |
| Drug dependence: stress and dysregulation of brain reward pathways. | Kreek MJ et al. | β | 1998 | β |
| Effects of cyclazocine on cocaine self-administration in rats. | Glick SD et al. | β | 1998 | β |
| Increased responsiveness of mesolimbic and mesostriatal dopamine neurons to cocaine following repeated administration of a selective kappa-opioid receptor agonist. | Heidbreder CA et al. | β | 1998 | β |
| Intraaccumbens injections of substance P, morphine and amphetamine: effects on conditioned place preference and behavioral activity. | Schildein S et al. | β | 1998 | β |
| Kappa-opioid receptor blockade with nor-binaltorphimine modulates cocaine self-administration in drug-naive rats. | Kuzmin AV et al. | β | 1998 | β |
| Medication development of ibogaine as a pharmacotherapy for drug dependence. | Mash DC et al. | β | 1998 | β |
| Medication Development of Ibogaine as a Pharmacotherapy for Drug Dependence<sup>a</sup>. | Mash DC et al. | β | 1998 | β |
| Modulation of volitional ethanol intake in the rat by central delta-opioid receptors. | Franck J et al. | β | 1998 | β |
| Mu and kappa opioid receptors in periaqueductal gray and rostral ventromedial medulla. | Gutstein HB et al. | β | 1998 | β |
| mu-Opposing actions of the kappa-opioid receptor. | Pan ZZ | β | 1998 | β |
| Opioid receptor gene expression in the rat brain during ontogeny, with special reference to the mesostriatal system: an in situ hybridization study. | Georges F et al. | β | 1998 | β |
| Opioid receptor modulation of feeding-evoked dopamine release in the rat nucleus accumbens. | Taber MT et al. | β | 1998 | β |
| Opioid reward mechanisms: a key role in drug abuse? | Herz A | β | 1998 | β |
| Rational treatment of addiction. | Terenius L | β | 1998 | β |
| Repeated treatment with the selective kappa opioid agonist U-69593 produces a marked depletion of dopamine D2 receptors. | Izenwasser S et al. | β | 1998 | β |
| Sensitization to the conditioned rewarding effects of morphine and cocaine: differential effects of the kappa-opioid receptor agonist U69593. | Shippenberg TS et al. | β | 1998 | β |
| Structure-activity relationship studies of dynorphin A and related peptides. | Naqvi T et al. | β | 1998 | β |
| A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants. | Pierce RC et al. | β | 1997 | β |
| Amphetamine-induced preprodynorphin mRNA expression and kappa-opioid receptor binding in basal ganglia of adult rats after prenatal exposure to diazepam. | Inderbitzin S et al. | β | 1997 | β |
| Cellular mechanism for anti-analgesic action of agonists of the kappa-opioid receptor. | Pan ZZ et al. | β | 1997 | β |
| Characterization of the mu and delta opioid receptors in the brain of the C57BL/6 and DBA/2 mice, selected for their differences in voluntary ethanol consumption. | de Waele JP et al. | β | 1997 | β |
| Content of dynorphins and kappa-opioid receptors in distinct brain regions of C57BL/6 and DBA/2 mice. | Jamensky NT et al. | β | 1997 | β |
| Evidence for roles of kappa-opioid and NMDA receptors in the mechanism of action of ibogaine. | Glick SD et al. | β | 1997 | β |
| Kappa1- and kappa2-opioid receptors mediating presynaptic inhibition of dopamine and acetylcholine release in rat neostriatum. | Schoffelmeer AN et al. | β | 1997 | β |
| Kappa2 opioid receptors in limbic areas of the human brain are upregulated by cocaine in fatal overdose victims. | Staley JK et al. | β | 1997 | β |
| Kappa-opioid receptor agonist U50,488H modulates cocaine and morphine self-administration in drug-naive rats and mice. | Kuzmin AV et al. | β | 1997 | β |
| Molecular adaptations to psychostimulants in striatal neurons: toward a pathophysiology of addiction. | Genova L et al. | β | 1997 | β |
| Naltrexone effects on ethanol drinking acquisition and on established ethanol consumption in C57BL/6J mice. | Phillips TJ et al. | β | 1997 | β |
| Nicotine and heroin augment cocaine-induced dopamine overflow in nucleus accumbens. | Zernig G et al. | β | 1997 | β |
| Nociceptin/orphanin FQ and the opioid receptor-like ORL1 receptor. | Meunier JC | β | 1997 | β |
| Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80) and related novel nonpeptide delta opioid receptor ligands. | Calderon SN et al. | β | 1997 | β |
| Prodynorphin allelic distribution in Scandinavian chronic alcoholics. | Geijer T et al. | β | 1997 | β |
| Sensitization to the behavioral effects of cocaine: modulation by dynorphin and kappa-opioid receptor agonists. | Shippenberg TS et al. | β | 1997 | β |
| U-50,488H, a selective kappa opioid receptor agonist, ameliorates memory impairments induced by muscarinic autoreceptor agonist, carbachol in mice. | Hiramatsu M et al. | β | 1997 | β |
| Cyclazocine revisited. | Archer S et al. | β | 1996 | β |
| D1 and D2 receptor regulation of preproenkephalin and preprodynorphin mRNA in rat striatum following acute injection of amphetamine or methamphetamine. | Wang JQ et al. | β | 1996 | β |
| Dynorphin regulates D1 dopamine receptor-mediated responses in the striatum: relative contributions of pre- and postsynaptic mechanisms in dorsal and ventral striatum demonstrated by altered immediate-early gene induction. | Steiner H et al. | β | 1996 | β |
| Feeding, drug abuse, and the sensitization of reward by metabolic need. | Carr KD | β | 1996 | β |
| Guinea pig preprodynorphin mRNA: primary structure and regional quantitation in the brain. | Yuferov VP et al. | β | 1996 | β |
| Neuropharmacological characterization of local ibogaine effects on dopamine release. | Reid MS et al. | β | 1996 | β |
| Pharmacological screen for activities of 12-hydroxyibogamine: a primary metabolite of the indole alkaloid ibogaine. | Staley JK et al. | β | 1996 | β |
| Dynorphin-immunoreactive neurons in the rat nucleus accumbens: ultrastructure and synaptic input from terminals containing substance P and/or dynorphin. | Van Bockstaele EJ et al. | β | 1995 | β |
| Dynorphin opioid inhibition of cocaine-induced, D1 dopamine receptor-mediated immediate-early gene expression in the striatum. | Steiner H et al. | β | 1995 | β |
| Effects of morphine on different aspects of social play in juvenile rats. | Vanderschuren LJ et al. | β | 1995 | β |
| Opioid blockade attenuates acquisition and expression of cocaine-induced place preference conditioning in rats. | Gerrits MA et al. | β | 1995 | β |
| Opioid effects of psychotropic analgesic nitrous oxide on the dopaminergic system. | Gillman MA et al. | β | 1995 | β |
| Strain differences in the rewarding and dopamine-releasing effects of morphine in rats. | Shoaib M et al. | β | 1995 | β |
| The effect of prolonged treatment with imipramine and electroconvulsive shock on the levels of endogenous enkephalins in the nucleus accumbens and the ventral tegmentum of the rat. | Dziedzicka-Wasylewska M et al. | β | 1995 | β |
| The effects of morphine treatment and morphine withdrawal on the dynorphin and enkephalin systems in Sprague-Dawley rats. | Nylander I et al. | β | 1995 | β |
| The effects of the kappa agonist U-50,488 on cocaine-induced conditioned and unconditioned behaviors and Fos immunoreactivity. | Crawford CA et al. | β | 1995 | β |
| Acute and chronic cocaine administration differentially alters striatal opioid and nuclear transcription factor mRNAs. | Daunais JB et al. | β | 1994 | β |
| Central nervous system-immune system interactions: psychoneuroendocrinology of stress and its immune consequences. | Black PH | β | 1994 | β |
| Differences between alcohol-preferring (AA) and alcohol-avoiding (ANA) rats in the prodynorphin and proenkephalin systems. | Nylander I et al. | β | 1994 | β |
| Dynorphin-immunoreactive terminals in the rat nucleus accumbens: cellular sites for modulation of target neurons and interactions with catecholamine afferents. | Van Bockstaele EJ et al. | β | 1994 | β |
| Endogenous kappa-opioid systems in opiate withdrawal: role in aversion and accompanying changes in mesolimbic dopamine release. | Spanagel R et al. | β | 1994 | β |
| Genetics of alcoholism: role of the endogenous opioid system. | Gianoulakis C et al. | β | 1994 | β |
| Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: an in situ hybridization study. | Mansour A et al. | β | 1994 | β |
| NMDA receptors mediate amphetamine-induced upregulation of zif/268 and preprodynorphin mRNA expression in rat striatum. | Wang JQ et al. | β | 1994 | β |
| Reward and its control by dynorphin peptides. | Terenius L | β | 1994 | β |
| An ATP-sensitive potassium channel blocker abolishes the potentiating effect of morphine on the bicuculline-induced convulsion in mice. | Narita M et al. | β | 1993 | β |
| Antagonism of the morphine-induced Straub tail reaction by kappa-opioid receptor activation in mice. | Narita M et al. | β | 1993 | β |
| Differential down- and up-regulation of rat brain opioid receptor types and subtypes by buprenorphine. | Belcheva MM et al. | β | 1993 | β |
| Endogenous opioids and excessive alcohol consumption. | Gianoulakis C | β | 1993 | β |
| Interacting presynaptic kappa-opioid and GABAA receptors modulate dopamine release from rat striatal synaptosomes. | Ronken E et al. | β | 1993 | β |