Genetic influences on DSM-III-R drug abuse and dependence: a study of 3,372 twin pairs.
paper
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- Authors
- Tsuang, M T; Lyons, M J; Eisen, S A; Goldberg, J; True, W; Lin, N; Meyer, J M; Toomey, R; Faraone, S V; Eaves, L
- Year
- 1996
- Journal
- American journal of medical genetics
- PMID
- 8886164
- DOI
- 10.1002/(SICI)1096-8628(19960920)67:5<473::AID-AJMG6>3.0.CO;2-L
Research and clinical experience indicate that drug use disorders tend to run in families. The objective of this study was to distinguish between the family environment and genetic factors as the source of this observed family resemblance. Data were collected by telephone interview from members of the Vietnam Era Twin Registry, comprising male twin pairs who served in the U.S. military between 1965 and 1975. There were 3,372 pairs in which both twins participated. Drug use disorder was defined as receiving a diagnosis of drug abuse or dependence according to DSM-III-R; 10.1% of the sample had abused or been dependent on at least one illicit drug. A significant difference between concordance rates for monozygotic (26.2%) vs. dizygotic (16.5%) twins indicated a genetic influence on drug use disorder. Biometrical modeling indicated that genetic factors (34% of the variance), the environment shared by twins (28% of the variance), and the nonshared environment (38% of the variance) had significant influences of similar magnitudes on the individual's risk of developing a drug use disorder. These results support the application of molecular genetic approaches to elucidate the genetic influence on drug use disorder, as well as the potential efficacy of environmental intervention to reduce risk.
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| Examination of the causes of covariation between conduct disorder symptoms and vulnerability to drug dependence. | Button TM et al. | β | 2006 | β |
| Genetic and environmental vulnerabilities underlying adolescent substance use and problem use: general or specific? | Young SE et al. | β | 2006 | β |
| Genetic variant of prodynorphin gene is risk factor for methamphetamine dependence. | Nomura A et al. | β | 2006 | β |
| Genome-wide linkage analysis of heroin dependence in Han Chinese: results from wave one of a multi-stage study. | Glatt SJ et al. | β | 2006 | β |
| Genomewide linkage scan for opioid dependence and related traits. | Gelernter J et al. | β | 2006 | β |
| Illicit psychoactive substance use, abuse and dependence in a population-based sample of Norwegian twins. | Kendler KS et al. | β | 2006 | β |
| Is there heterogeneity among syndromes of substance use disorder for illicit drugs? | Beseler C et al. | β | 2006 | β |
| Molecular genetics of addiction vulnerability. | Uhl GR | β | 2006 | β |
| NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice. | Ishiguro H et al. | β | 2006 | β |
| Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism. | Johnson C et al. | β | 2006 | β |
| Risk factors for cocaine-induced paranoia in cocaine-dependent sibling pairs. | Kalayasiri R et al. | β | 2006 | β |
| Substance use disorders: Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) and International Classification of Diseases, tenth edition (ICD-10). | Hasin D et al. | β | 2006 | β |
| Symbiotic relationship of pharmacogenetics and drugs of abuse. | Rutter JL | β | 2006 | β |
| The association of early adolescent problem behavior and adult psychopathology: a multivariate behavioral genetic perspective. | McGue M et al. | β | 2006 | β |
| Using the brain P300 response to identify novel phenotypes reflecting genetic vulnerability for adolescent substance misuse. | Yoon HH et al. | β | 2006 | β |
| Anticraving medications for relapse prevention: a possible new class of psychoactive medications. | O'Brien CP | β | 2005 | β |
| CASASTART: a community-based, school-centered intervention for high-risk youth. | Murray LF et al. | β | 2005 | β |
| Correlates of initiation of injection drug use among young drug users in Baltimore, Maryland: the need for early intervention. | Sherman SG et al. | β | 2005 | β |
| Genetic studies of pathological gambling: a review of methodology and analyses of data from the Vietnam Era Twin Registry. | Shah KR et al. | β | 2005 | β |
| Genetic susceptibility to substance dependence. | Hiroi N et al. | β | 2005 | β |
| Genetic variation in heroin-induced changes in behaviour: effects of B6 strain dose on conditioned reward and locomotor sensitization in 129-B6 hybrid mice. | Szumlinski KK et al. | β | 2005 | β |
| Genomewide linkage scan for cocaine dependence and related traits: significant linkages for a cocaine-related trait and cocaine-induced paranoia. | Gelernter J et al. | β | 2005 | β |
| Ghrelin precursor gene polymorphism and methamphetamine dependence in the Korean population. | Yoon SJ et al. | β | 2005 | β |
| Haplotype association between GABAA receptor gamma2 subunit gene (GABRG2) and methamphetamine use disorder. | Nishiyama T et al. | β | 2005 | β |
| Heritability of substance dependence in a native American population. | Wilhelmsen KC et al. | β | 2005 | β |
| Paternal alcoholism and offspring conduct disorder: evidence for the 'common genes' hypothesis. | Haber JR et al. | β | 2005 | β |
| Pooled association genome scanning: validation and use to identify addiction vulnerability loci in two samples. | Liu QR et al. | β | 2005 | β |
| Predicting aberrant behaviors in opioid-treated patients: preliminary validation of the Opioid Risk Tool. | Webster LR et al. | β | 2005 | β |
| The genetics of addictions: uncovering the genes. | Goldman D et al. | β | 2005 | β |
| The X-box binding protein 1 (XBP1) gene is not associated with methamphetamine dependence. | Morita Y et al. | β | 2005 | β |
| Association analysis of the DRD4 and COMT genes in methamphetamine abuse. | Li T et al. | β | 2004 | β |
| Attention-deficit/hyperactivity disorder and the substance use disorders: the nature of the relationship, subtypes at risk, and treatment issues. | Wilens TE | β | 2004 | β |
| Molecular genetics of substance abuse vulnerability: remarkable recent convergence of genome scan results. | Uhl GR | β | 2004 | β |
| Molecular genetic underpinnings of human substance abuse vulnerability: likely contributions to understanding addiction as a mnemonic process. | Uhl GR | β | 2004 | β |
| No association found between the type 1 sigma receptor gene polymorphisms and methamphetamine abuse in the Japanese population: a collaborative study by the Japanese Genetics Initiative for Drug Abuse. | Inada T et al. | β | 2004 | β |
| Paternal alcohol dependence and offspring suicidal behaviors in a children-of-twins study. | Glowinski AL et al. | β | 2004 | β |
| The effect of parental alcohol and drug disorders on adolescent personality. | Elkins IJ et al. | β | 2004 | β |
| A genome-wide search for quantitative trait loci influencing substance dependence vulnerability in adolescence. | Stallings MC et al. | β | 2003 | β |
| Delivering more effective treatment to adolescents: Improving the juvenile drug court model. | Belenko S et al. | β | 2003 | β |
| Gender-specific contribution of the GABA(A) subunit genes on 5q33 in methamphetamine use disorder. | Lin SK et al. | β | 2003 | β |
| Nine- or fewer repeat alleles in VNTR polymorphism of the dopamine transporter gene is a strong risk factor for prolonged methamphetamine psychosis. | Ujike H et al. | β | 2003 | β |
| Substance use disorders, externalizing psychopathology, and P300 event-related potential amplitude. | Iacono WG et al. | β | 2003 | β |
| A family study of the high-risk children of opioid- and alcohol-dependent parents. | Wilens TE et al. | β | 2002 | β |
| Etiologic connections among substance dependence, antisocial behavior, and personality: modeling the externalizing spectrum. | Krueger RF et al. | β | 2002 | β |
| Gene-environment interaction effects on behavioral variation and risk of complex disorders: the example of alcoholism and other psychiatric disorders. | Heath AC et al. | β | 2002 | β |
| Genetic segregation analysis of alcohol and other substance-use disorders in families with recurrent, early-onset major depression. | Maher BS et al. | β | 2002 | β |
| Is addiction an illness--can it be treated? | McLellan AT | β | 2002 | β |
| Parental substance use disorder and the risk of adolescent drug abuse: an event history analysis. | Hoffmann JP et al. | β | 2002 | β |
| Potentially functional polymorphism in the promoter region of prodynorphin gene may be associated with protection against cocaine dependence or abuse. | Chen AC et al. | β | 2002 | β |
| Relationship of the delta-opioid receptor gene to heroin abuse in a large Chinese case/control sample. | Xu K et al. | β | 2002 | β |
| Sedative use and misuse in the United States. | Goodwin RD et al. | β | 2002 | β |
| Sex differences in shared genetic and environmental influences between conduct disorder symptoms and marijuana use in adolescents. | Miles DR et al. | β | 2002 | β |
| Substance abuse vulnerability loci: converging genome scanning data. | Uhl GR et al. | β | 2002 | β |
| Temporal association between childhood psychopathology and substance use disorders: findings from a sample of adults with opioid or alcohol dependency. | Hahesy AL et al. | β | 2002 | β |
| The genetics of substance abuse. | Hardie TL | β | 2002 | β |
| Toward a comprehensive developmental model for major depression in women. | Kendler KS et al. | β | 2002 | β |
| Addiction and the brain: the neurobiology of compulsion and its persistence. | Hyman SE et al. | β | 2001 | β |
| An integrative approach for studying the etiology of alcoholism and other addictions. | Jacob T et al. | β | 2001 | β |
| A twin study of the association between pathological gambling and antisocial personality disorder. | Slutske WS et al. | β | 2001 | β |
| A twin study on sensation seeking, risk taking behavior and marijuana use. | Miles DR et al. | β | 2001 | β |
| Family history influence on drug abuse severity and treatment outcome. | Pickens RW et al. | β | 2001 | β |
| Novel and previously reported single-nucleotide polymorphisms in the human 5-HT(1B) receptor gene: no association with cocaine or alcohol abuse or dependence. | Cigler T et al. | β | 2001 | β |
| Polysubstance abuse-vulnerability genes: genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms. | Uhl GR et al. | β | 2001 | β |
| Schizophrenia and the cannabinoid receptor type 1 (CB1): association study using a single-base polymorphism in coding exon 1. | Leroy S et al. | β | 2001 | β |
| Serotonin transporter (5-HTT) gene polymorphisms and susceptibility to cocaine dependence among African-American individuals. | Patkar AA et al. | β | 2001 | β |
| The biosocial female choice theory of social stratification. | Ellis L | β | 2001 | β |
| Confirmation of an excess of the high enzyme activity COMT val allele in heroin addicts in a family-based haplotype relative risk study. | Horowitz R et al. | β | 2000 | β |
| Detection of single nucleotide polymorphisms of the human mu opioid receptor gene by hybridization or single nucleotide extension on custom oligonucleotide gelpad microchips: potential in studies of addiction. | LaForge KS et al. | β | 2000 | β |
| Dopamine D4 receptor gene and severity of dependence. | Lusher J et al. | β | 2000 | β |
| DRD4 exon III VNTR polymorphism-susceptibility factor for heroin dependence? Results of a case-control and a family-based association approach. | Franke P et al. | β | 2000 | β |
| Environmental transmission of DSM-IV substance use disdorders in adoptive and step families. | Newlin DB et al. | β | 2000 | β |
| Genetic and environmental influences on adolescent substance use and abuse. | McGue M et al. | β | 2000 | β |
| Genetic and environmental influences on posttraumatic stress disorder, alcohol and drug dependence in twin pairs. | Xian H et al. | β | 2000 | β |
| Genetic studies of substance abuse. | Vanyukov MM et al. | β | 2000 | β |
| Implications of genetic epidemiology for the prevention of substance use disorders. | Merikangas KR et al. | β | 2000 | β |
| Multivariate assessment of factors influencing illicit substance use in twins from female-female pairs. | Karkowski LM et al. | β | 2000 | β |
| Patterns of alcohol and drug use in adolescents can be predicted by parental substance use disorders. | Biederman J et al. | β | 2000 | β |
| Pharmacogenomics and addiction to opiates. | Lichtermann D et al. | β | 2000 | β |
| Psychiatric disorders and impairment in the children of opiate addicts: prevalances and distribution by ethnicity. | Nunes EV et al. | β | 2000 | β |
| Reward deficiency syndrome: genetic aspects of behavioral disorders. | Comings DE et al. | β | 2000 | β |
| Self-Reported zygosity and the equal-environments assumption for psychiatric disorders in the Vietnam Era Twin Registry. | Xian H et al. | β | 2000 | β |
| Caffeine intake, tolerance, and withdrawal in women: a population-based twin study. | Kendler KS et al. | β | 1999 | β |
| Genetic and environmental influences on transitions in drug use. | Tsuang MT et al. | β | 1999 | β |
| Genetic and environmental risk factors in the aetiology of illicit drug initiation and subsequent misuse in women. | Kendler KS et al. | β | 1999 | β |
| Genetics of alcoholism and substance abuse. | Enoch MA et al. | β | 1999 | β |
| Hallucinogen, opiate, sedative and stimulant use and abuse in a population-based sample of female twins. | Kendler KS et al. | β | 1999 | β |
| Interrelationship of genetic and environmental influences on conduct disorder and alcohol and marijuana dependence symptoms. | True WR et al. | β | 1999 | β |
| Resiliency factors protecting against teenage alcohol use and smoking: influences of religion, religious involvement and values, and ethnicity in the Missouri Adolescent Female Twin Study. | Heath AC et al. | β | 1999 | β |
| Risk/protective factors among addicted mothers' offspring: a replication study. | Weissman MM et al. | β | 1999 | β |
| The heritability of alcoholism symptoms: "indicators of genetic and environmental influence in alcohol-dependent individuals" revisited. | Slutske WS et al. | β | 1999 | β |
| The relationship between parental history and substance use severity in drug treatment patients. | Boyd SJ et al. | β | 1999 | β |
| Additional evidence for an association between the dopamine D4 receptor (D4DR) exon III seven-repeat allele and substance abuse in opioid dependent subjects: relationship of treatment retention to genotype and personality. | Mel H et al. | β | 1998 | β |
| Cannabis use, abuse, and dependence in a population-based sample of female twins. | Kendler KS et al. | β | 1998 | β |
| Cocaine use, abuse and dependence in a population-based sample of female twins. | Kendler KS et al. | β | 1998 | β |
| Depression and stimulant dependence: neurobiology and pharmacotherapy. | Kosten TR et al. | β | 1998 | β |
| Genetic and environmental influences on drug use and abuse/dependence in male and female twins. | van den Bree MB et al. | β | 1998 | β |
| Genetic influences in antisocial personality and drug use disorders. | van den Bree MB et al. | β | 1998 | β |
| Long-term reliability and validity of alcoholism diagnoses and symptoms in a large national telephone interview survey. | Slutske WS et al. | β | 1998 | β |
| The ecogenetics of schizophrenia: a review. | van Os J et al. | β | 1998 | β |
| High-activity catechol-O-methyltransferase allele is more prevalent in polysubstance abusers. | Vandenbergh DJ et al. | β | 1997 | β |
| How do genes influence marijuana use? The role of subjective effects. | Lyons MJ et al. | β | 1997 | β |
| The influence of familial and non-familial factors on the association between major depression and substance abuse/dependence in 1874 monozygotic male twin pairs. | Lin N et al. | β | 1996 | β |