Dopamine beta-hydroxylase gene (DbetaH) -1021C-->T influences self-reported paranoia during cocaine self-administration.
paper
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- Authors
- Kalayasiri, Rasmon; Sughondhabirom, Atapol; Gueorguieva, Ralitza; Coric, Vladimir; Lynch, Wendy J; Lappalainen, Jaakko; Gelernter, Joel; Cubells, Joseph F; Malison, Robert T
- Year
- 2007
- Journal
- Biological psychiatry
- PMID
- 17157269
- DOI
- 10.1016/j.biopsych.2006.08.012
BACKGROUND: Variation in the gene for dopamine beta-hydroxylase (DbetaH) has been reported to associate with cocaine-induced paranoia as assessed by retrospective self-report. This association has yet to be tested prospectively. METHODS: Visual analog scale (VAS) ratings of paranoia were obtained in 31 cocaine users during three cocaine self-administration sessions (8, 16, and 32 mg/70 kg). Pharmacogenetic interactions between cocaine and a putative functional polymorphism in DbetaH (-1021C-->T) were assessed. RESULTS: VAS self-ratings showed significant or trend-level interactions of genotype and time during each session (p = .004, .09 and .003, respectively) with TT homozygotes endorsing greater paranoia over time than either CT or CC individuals. Interactions were significant at all doses in African Americans (n = 19; p = .02, .04 and .05). No other demographic or experimental variable distinguished genotypic groups. CONCLUSIONS: Results indicate that individuals homozygous for the 'very low-activity' T allele at DbetaH -1021C-->T show an increased propensity to paranoia over time during cocaine self-administration.
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| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | β | 2017 | β |
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| Risk factors for cocaine-induced psychosis in cocaine-dependent patients. | Roncero C et al. | β | 2013 | β |
| Serum brain-derived neurotrophic factor levels and cocaine-induced transient psychotic symptoms. | Corominas-Roso M et al. | β | 2013 | β |
| A single-day paradigm of self-regulated human cocaine administration. | Matuskey D et al. | β | 2012 | β |
| Association between dopamine beta hydroxylase gene polymorphism and age at onset in male schizophrenia. | Barlas IΓ et al. | β | 2012 | β |
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| The genetics of addiction-a translational perspective. | Agrawal A et al. | β | 2012 | β |
| Association between polymorphisms in catechol-O-methyltransferase (COMT) and cocaine-induced paranoia in European-American and African-American populations. | Ittiwut R et al. | β | 2011 | β |
| Linkage analysis of plasma dopamine Ξ²-hydroxylase activity in families of patients with schizophrenia. | Cubells JF et al. | β | 2011 | β |
| Adolescent cannabis use increases risk for cocaine-induced paranoia. | Kalayasiri R et al. | β | 2010 | β |
| Association study between the DAT1, DBH and DRD2 genes and cocaine dependence in a Spanish sample. | FernΓ ndez-Castillo N et al. | β | 2010 | β |
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| Norepinephrine signaling through beta-adrenergic receptors is critical for expression of cocaine-induced anxiety. | Schank JR et al. | β | 2008 | β |
| Physiogenomic analysis of localized FMRI brain activity in schizophrenia. | Windemuth A et al. | β | 2008 | β |