Genetic and environmental influences on substance initiation, use, and problem use in adolescents.
paper
Cited
Public
Unavailable
- Authors
- Rhee, Soo Hyun; Hewitt, John K; Young, Susan E; Corley, Robin P; Crowley, Thomas J; Stallings, Michael C
- Year
- 2003
- Journal
- Archives of general psychiatry
- PMID
- 14662558
- DOI
- 10.1001/archpsyc.60.12.1256
BACKGROUND: We conducted a sibling/twin/adoption study of substance initiation, use, and problem use, estimating the relative contribution of genetic and environmental influences on these phenotypes in adolescents. METHODS: The participants were 345 monozygotic twin pairs, 337 dizygotic twin pairs, 306 biological sibling pairs, and 74 adoptive sibling pairs assessed by the Colorado Center for the Genetics and Treatment of Antisocial Drug Dependence, Denver and Boulder. The initiation, use, and problem use of tobacco, alcohol, marijuana, and other illicit drugs were assessed. Tetrachoric correlations were computed for each group, and univariate model-fitting analyses were conducted. RESULTS: There were moderate to substantial genetic influences, with the exception of alcohol use and any drug use, and modest to moderate shared environmental influences on substance initiation, use, and problem use. For alcohol and any drug, heritability was higher and the magnitude of shared environmental influences was lower for problem use than for initiation or use. Environmental influences shared only by twin pairs had a significant effect on tobacco initiation, alcohol use, and any drug use. For tobacco use, tobacco problem use, and marijuana initiation, heritability was higher and the magnitude of shared environmental influences was lower in female than in male adolescents. There was no evidence for sex-specific genetic or shared environmental influences on any variable. CONCLUSIONS: The moderate to substantial heritabilities found for adolescents in the present study are comparable to those found in twin studies of adult substance use and substance use disorders. The finding that problem use is more heritable than initiation and use is also consistent with the results of adult twin studies. The significance of environmental influences shared only by twin pairs on tobacco initiation, alcohol use, and any drug use suggests the influences of peers, accessibility of substances, and sibling interaction.
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| Genetic and environmental contributions to the diversity of substances used in adolescent twins: a longitudinal study of age and sex effects. | Derringer J et al. | β | 2008 | β |
| Genetic and environmental influences on the rate of progression to alcohol dependence in young women. | Sartor CE et al. | β | 2008 | β |
| Measured environmental contributions to cannabis abuse/dependence in an offspring of twins design. | Scherrer JF et al. | β | 2008 | β |
| Review. Genetics of addictions: strategies for addressing heterogeneity and polygenicity of substance use disorders. | Wong CC et al. | β | 2008 | β |
| Role of the dopamine transporter in the action of psychostimulants, nicotine, and other drugs of abuse. | Zhu J et al. | β | 2008 | β |
| The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults. | Schlaepfer IR et al. | β | 2008 | β |
| The relative contribution of genes and environment to alcohol use in early adolescents: are similar factors related to initiation of alcohol use and frequency of drinking? | Poelen EA et al. | β | 2008 | β |
| What predicts illicit drug use versus police-registered drug offending? Findings from the Finnish "From a Boy to a Man" birth cohort study. | NiemelΓ€ S et al. | β | 2008 | β |
| A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: evidence for linkage on chromosomes 3 and 9. | Hopfer CJ et al. | β | 2007 | β |
| Age of first marijuana use and the occurrence of marijuana use disorders in Southwest California Indians. | Ehlers CL et al. | β | 2007 | β |
| Ethnic differences in the predictors of drug and alcohol abuse in hospitalized adolescents. | Becker DF et al. | β | 2007 | β |
| Exploring the inter-relationship of smoking age-at-onset, cigarette consumption and smoking persistence: genes or environment? | Morley KI et al. | β | 2007 | β |
| Exploring the relationship between genetic and environmental influences on initiation and progression of substance use. | Fowler T et al. | β | 2007 | β |
| Heritability of illicit drug use and transition to dependence in Southwest California Indians. | Ehlers CL et al. | β | 2007 | β |
| Historical and cultural aspects of man's relationship with addictive drugs. | Crocq MA | β | 2007 | β |
| Individual differences in response to novelty predict prefrontal cortex dopamine transporter function and cell surface expression. | Zhu J et al. | β | 2007 | β |
| Longitudinal modeling of genetic and environmental influences on self-reported availability of psychoactive substances: alcohol, cigarettes, marijuana, cocaine and stimulants. | Gillespie NA et al. | β | 2007 | β |
| Okey Lecture 2006: identifying the neurobiological mechanisms of addictive behaviour. | Schumann G | β | 2007 | β |
| Personality differences in monozygotic twins discordant for cannabis use. | Vink JM et al. | β | 2007 | β |
| Reasons for increased substance use in psychosis. | Gregg L et al. | β | 2007 | β |
| The association between conduct problems and the initiation and progression of marijuana use during adolescence: a genetic analysis across time. | Shelton K et al. | β | 2007 | β |
| The role of conduct disorder in explaining the comorbidity between alcohol and illicit drug dependence in adolescence. | Button TM et al. | β | 2007 | β |
| Age at first intoxication and alcohol use disorders in Southwest California Indians. | Ehlers CL et al. | β | 2006 | β |
| A risk-taking "set" in a novel task among adolescents with serious conduct and substance problems. | Crowley TJ et al. | β | 2006 | β |
| Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. | Agrawal A et al. | β | 2006 | β |
| Assortative mating for cigarette smoking and for alcohol consumption in female Australian twins and their spouses. | Agrawal A et al. | β | 2006 | β |
| Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescents. | Hopfer CJ et al. | β | 2006 | β |
| Challenges in genetic studies of the etiology of substance use and substance use disorders: introduction to the special issue. | Prescott CA et al. | β | 2006 | β |
| Colorado Twin Registry. | Rhea SA et al. | β | 2006 | β |
| Commentary: understanding pathways to cannabis use and from use to harm. | Macleod J et al. | β | 2006 | β |
| Continuities and discontinuities in psychopathology between childhood and adult life. | Rutter M et al. | β | 2006 | β |
| Duration of cannabis use--a novel phenotype? | Lynskey MT et al. | β | 2006 | β |
| Genetic and environmental contributions to common psychopathologies of childhood and adolescence: a study of twins and their siblings. | Ehringer MA et al. | β | 2006 | β |
| Genetic and environmental vulnerabilities underlying adolescent substance use and problem use: general or specific? | Young SE et al. | β | 2006 | β |
| New findings on the genetic influences on alcohol use and dependence. | Higuchi S et al. | β | 2006 | β |
| Prediction of drug and alcohol abuse in hospitalized adolescents: comparisons by gender and substance type. | Becker DF et al. | β | 2006 | β |
| Psychiatric comorbidity and progression in drug use in adult male twins: implications for the design of genetic association studies. | Todorov AA et al. | β | 2006 | β |
| Reward and punishment sensitivity in dysfunctional eating and hazardous drinking women: associations with family risk. | Loxton NJ et al. | β | 2006 | β |
| The genetic epidemiology of cannabis use, abuse and dependence. | Agrawal A et al. | β | 2006 | β |
| The moderating effects of religiosity on the genetic and environmental determinants of smoking initiation. | Timberlake DS et al. | β | 2006 | β |
| The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages. | Dick DM et al. | β | 2006 | β |
| Translating genetics, cognitive science, and other basic science research findings into applications for prevention. | Ames SL et al. | β | 2006 | β |
| Trends in initiation of alcohol use in the United States 1975 to 2003. | Faden VB | β | 2006 | β |
| Addiction: a disease of learning and memory. | Hyman SE | β | 2005 | β |
| A family smoking index to capture genetic influence in smoking: rationale and two validation studies. | Drobes DJ et al. | β | 2005 | β |
| An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. | Hu X et al. | β | 2005 | β |
| Contrasting predictors of readiness for substance abuse treatment in adults and adolescents: a latent variable analysis of DATOS and DATOS-A participants. | Handelsman L et al. | β | 2005 | β |
| Co-twin dependence modifies heritability of abstinence and alcohol use: a population-based study of Finnish twins. | Penninkilampi-Kerola V et al. | β | 2005 | β |
| Genetic influences on quantity of alcohol consumed by adolescents and young adults. | Hopfer CJ et al. | β | 2005 | β |
| Impact of substance use on the onset and course of early psychosis. | Verdoux H et al. | β | 2005 | β |
| Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction. | Caspi A et al. | β | 2005 | β |
| Relationship of age of first drink to child behavioral problems and family psychopathology. | Kuperman S et al. | β | 2005 | β |
| Genetics, pharmacokinetics, and neurobiology of adolescent alcohol use. | β | β | 2004 | β |
| Is the party over? Cannabis and juvenile psychiatric disorder: the past 10 years. | Rey JM et al. | β | 2004 | β |