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Chunk #19 — Results — Linkage analyses

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Linkage analyses of cannabis dependence, craving, and withdrawal in the San Francisco family study.
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Analyses of multipoint variance component LOD scores for the dichotomous DSM-IV cannabis dependence phenotype did not yield any peaks that achieved genome-wide significance. However, two sites were identified with LOD scores over 2.0, a site on chromosome 1 between 142 and 159 cM with a peak at 154 cM (LOD = 2.1), and a site on chromosome 2 between 194 and 216 cM with a peak at 211 cM (LOD = 2.6). These findings are presented in Figure 1 and Table 2.