A genome-wide search for quantitative trait Loci that influence antisocial drug dependence in adolescence.
paper
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- Authors
- Stallings, Michael C; Corley, Robin P; Dennehey, Briana; Hewitt, John K; Krauter, Kenneth S; Lessem, Jeffrey M; Mikulich-Gilbertson, Susan K; Rhee, Soo Hyun; Smolen, Andrew; Young, Susan E; Crowley, Thomas J
- Year
- 2005
- Journal
- Archives of general psychiatry
- PMID
- 16143736
- DOI
- 10.1001/archpsyc.62.9.1042
BACKGROUND: Among adolescents, externalizing problem behavior and substance use disorders are often comorbid. Familial influences, including shared genetic risk factors, may account for part of this comorbidity. Previously we reported 2 chromosomal regions (3q24-3q25 and 9q34) likely to contain genes that influence substance dependence vulnerability (DV) in adolescence. OBJECTIVES: To identify quantitative trait loci (QTLs) that influence externalizing problem behavior in adolescence and to determine whether any identified QTL overlap chromosomal regions that influence DV. DESIGN: Regression-based QTL mapping procedures designed for selected sibling pair samples. SETTING: Patient probands were drawn from consecutive admissions to residential and outpatient (milieu-type) treatment facilities for substance abuse and delinquency operated by the University of Colorado; most of these patients were referred for treatment by juvenile justice or social service agencies. PATIENTS: A total of 249 proband-sibling pairs from 191 families were selected for the study. Patient probands were 13 to 19 years of age; siblings of the probands ranged in age from 12 to 25 years. MAIN OUTCOME MEASURES: A community-based sample of 4493 adolescents and young adults was used to define clinically significant, heritable, age- and sex-normed indexes of DV, conduct disorder symptoms (CDS), and a composite index of antisocial substance dependence (DV + CDS). Siblings and parents were genotyped for 374 microsatellite markers distributed across the 22 autosomes (mean intermarker distance, 9.2 centimorgans). RESULTS: For both DV and CDS, there was evidence of linkage to the same region on chromosome 9q34, as well as to 3q24-3q25 for DV, and a novel region on chromosome 17q12 for CDS. Our composite index (DV + CDS) yielded the strongest evidence for linkage (logarithm of odds = 2.65) to the chromosome 9q34 region. CONCLUSION: These results provide the first evidence of a potential molecular genetic basis for the comorbidity between DV and antisocial behavior.
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| The Relationship Between Tobacco and Cannabis Use: A Review. | Lemyre A et al. | — | 2019 | → |
| Conduct disorder in adolescent females: current state of research and study design of the FemNAT-CD consortium. | Freitag CM et al. | — | 2018 | → |
| Genetic influences on conduct disorder. | Salvatore JE et al. | — | 2018 | → |
| Positive expectancies mediate the association between sensation seeking and marijuana outcomes in at-risk young adults: A test of the acquired preparedness model. | Curry I et al. | — | 2018 | → |
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| Test for association of common variants in GRM7 with alcohol consumption. | Melroy-Greif WE et al. | — | 2016 | → |
| Brain cortical thickness in male adolescents with serious substance use and conduct problems. | Chumachenko SY et al. | — | 2015 | → |
| Genome-Wide Association Study of Behavioral Disinhibition in a Selected Adolescent Sample. | Derringer J et al. | — | 2015 | → |
| Examination of genetic variation in GABRA2 with conduct disorder and alcohol abuse and dependence in a longitudinal study. | Melroy WE et al. | — | 2014 | → |
| Genetic influences on alcohol use behaviors have diverging developmental trajectories: a prospective study among male and female twins. | Meyers JL et al. | — | 2014 | → |
| Reassessing the Effects of Early Adolescent Alcohol Use on Later Antisocial Behavior: A Longitudinal Study of Students in Victoria, Australia and Washington State, United States. | Hemphill SA et al. | — | 2014 | → |
| Behavioral disinhibition and sexual risk behavior among adolescents and young adults in Malawi. | Muchimba M et al. | — | 2013 | → |
| Frequency of alcohol use in adolescence as a marker for subsequent sexual risk behavior in adulthood. | Muchimba M et al. | — | 2013 | → |
| Nominal association with CHRNA4 variants and nicotine dependence. | Kamens HM et al. | — | 2013 | → |
| Externalizing behaviors are associated with SNPs in the CHRNA5/CHRNA3/CHRNB4 gene cluster. | Stephens SH et al. | — | 2012 | → |
| Genome-wide linkage scan of antisocial behavior, depression, and impulsive substance use in the UCSF family alcoholism study. | Gizer IR et al. | — | 2012 | → |
| Test of association between 10 single nucleotide polymorphisms in the oxytocin receptor gene and conduct disorder. | Sakai JT et al. | — | 2012 | → |
| Association of ADAM10 and CAMK2A polymorphisms with conduct disorder: evidence from family-based studies. | Jian XQ et al. | — | 2011 | → |
| Common and drug-specific genetic influences on subjective effects to alcohol, tobacco and marijuana use. | Haberstick BC et al. | — | 2011 | → |
| Family-based association analysis of alcohol dependence in the COGA sample and replication in the Australian twin-family study. | Wang KS et al. | — | 2011 | → |
| Genome-wide association study of conduct disorder symptomatology. | Dick DM et al. | — | 2011 | → |
| Psychometric and genetic architecture of substance use disorder and behavioral disinhibition measures for gene association studies. | Hicks BM et al. | — | 2011 | → |
| Behavioral genetics in antisocial spectrum disorders and psychopathy: a review of the recent literature. | Gunter TD et al. | — | 2010 | → |
| Genetic and environmental influences on psychiatric comorbidity: a systematic review. | Cerdá M et al. | — | 2010 | → |
| Linkage analyses of cannabis dependence, craving, and withdrawal in the San Francisco family study. | Ehlers CL et al. | — | 2010 | → |
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| Posttraumatic stress disorder and the genetic structure of comorbidity. | Wolf EJ et al. | — | 2010 | → |
| Test of association between GABRA2 (SNP rs279871) and adolescent conduct/alcohol use disorders utilizing a sample of clinic referred youth with serious substance and conduct problems, controls and available first degree relatives. | Sakai JT et al. | — | 2010 | → |
| The 'antisocial' person: an insight in to biology, classification and current evidence on treatment. | Rodrigo C et al. | — | 2010 | → |
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| Approaching the genomics of risk-taking behavior. | Bell AM | — | 2009 | → |
| Continuity of aggressive antisocial behavior from childhood to adulthood: The question of phenotype definition. | Hofvander B et al. | — | 2009 | → |
| Incorporating the family as a critical context in genetic studies of children: implications for understanding pathways to risky behavior and substance use. | Rende R et al. | — | 2009 | → |
| Perceived peer delinquency and the genetic predisposition for substance dependence vulnerability. | Button TM et al. | — | 2009 | → |
| Substance use and behaviour disorders in Puerto Rican youth: a migrant family study. | Merikangas KR et al. | — | 2009 | → |
| The relation of ADHD and violent aggression: What can we learn from epidemiological and genetic studies? | Retz W et al. | — | 2009 | → |
| A longitudinal study of alcohol use and antisocial behaviour in young people. | Young R et al. | — | 2008 | → |
| Association of candidate genes with antisocial drug dependence in adolescents. | Corley RP et al. | — | 2008 | → |
| Autosomal linkage analysis for cannabis use behaviors in Australian adults. | Agrawal A et al. | — | 2008 | → |
| Behavioral disinhibition and the development of early-onset addiction: common and specific influences. | Iacono WG et al. | — | 2008 | → |
| Externalizing disorders in American Indians: comorbidity and a genome wide linkage analysis. | Ehlers CL et al. | — | 2008 | → |
| Ordered subsets linkage analysis of antisocial behavior in substance use disorder among participants in the Collaborative Study on the Genetics of Alcoholism. | Jacobson KC et al. | — | 2008 | → |
| Phenomic, convergent functional genomic, and biomarker studies in a stress-reactive genetic animal model of bipolar disorder and co-morbid alcoholism. | Le-Niculescu H et al. | — | 2008 | → |
| Research review: DSM-V conduct disorder: research needs for an evidence base. | Moffitt TE et al. | — | 2008 | → |
| The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults. | Schlaepfer IR et al. | — | 2008 | → |
| A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: evidence for linkage on chromosomes 3 and 9. | Hopfer CJ et al. | — | 2007 | → |
| Fine mapping of a linkage region on chromosome 17p13 reveals that GABARAP and DLG4 are associated with vulnerability to nicotine dependence in European-Americans. | Lou XY et al. | — | 2007 | → |
| Mendelian randomization: a novel test of the gateway hypothesis and models of gene-environment interplay. | Irons DE et al. | — | 2007 | → |
| The human protein kinase C gamma gene (PRKCG) as a susceptibility locus for behavioral disinhibition. | Schlaepfer IR et al. | — | 2007 | → |
| The role of conduct disorder in explaining the comorbidity between alcohol and illicit drug dependence in adolescence. | Button TM et al. | — | 2007 | → |
| Adolescents and substance-related disorders: research agenda to guide decisions on Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-V). | Crowley TJ | — | 2006 | → |
| A joint genomewide linkage analysis of symptoms of alcohol dependence and conduct disorder. | Kendler KS et al. | — | 2006 | → |
| A risk-taking "set" in a novel task among adolescents with serious conduct and substance problems. | Crowley TJ et al. | — | 2006 | → |
| Case-control and within-family tests for an association between conduct disorder and 5HTTLPR. | Sakai JT et al. | — | 2006 | → |
| Challenges in genetic studies of the etiology of substance use and substance use disorders: introduction to the special issue. | Prescott CA et al. | — | 2006 | → |
| Examination of the causes of covariation between conduct disorder symptoms and vulnerability to drug dependence. | Button TM et al. | — | 2006 | → |
| Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence. | Lou XY et al. | — | 2006 | → |
| Genomewide linkage scan for opioid dependence and related traits. | Gelernter J et al. | — | 2006 | → |
| Interaction between MAO-A genotype and maltreatment in the risk for conduct disorder: failure to confirm in adolescent patients. | Young SE et al. | — | 2006 | → |
| Psychiatric comorbidity and progression in drug use in adult male twins: implications for the design of genetic association studies. | Todorov AA et al. | — | 2006 | → |
| Substance use disorder trajectory classes: diachronic integration of onset age, severity, and course. | Clark DB et al. | — | 2006 | → |
| The genetic epidemiology of cannabis use, abuse and dependence. | Agrawal A et al. | — | 2006 | → |
| The molecular genetic architecture of human personality: beyond self-report questionnaires. | Ebstein RP | — | 2006 | → |
| Understanding Psychopathology: Melding Behavior Genetics, Personality, and Quantitative Psychology to Develop an Empirically Based Model. | Krueger RF et al. | — | 2006 | → |