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Chunk #14 — Methods — Data analyses

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Linkage analyses of cannabis dependence, craving, and withdrawal in the San Francisco family study.
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Both genotype and phenotype data were available for 1647 individuals, and phenotype but not genotype data was available for an additional 720 individuals. Of these 720 individual 87 were relatives that could not b e contacted or did not provide DNA samples and 462 were probands that did not provide a sufficient number of genetically informative relatives for inclusion and the remaining 171 subjects were the relatives of these probands. Seven hundred and thirteen families were considered genetically informative for the heritability analyses. Families that contained sibling, half-sibling, avuncular or cousin pairs were included as being potentially genetically informative. These families ranged in size from 3 to 20 subjects (average 4.63 ± 2.13). The data includes: 563 parent-child, 1085 sibling, 40 half-sibling, 17 grandparent-grandchild, 238 avuncular, and 32 cousin relative pairs. An additional 177 families contained only a single individual with phenotype data. These individuals were included within some analyses to the extent that they contribute information about trait means and variance and the impact of covariates.