Ankyrin repeat: a unique motif mediating protein-protein interactions.
paper
Cited
Public
Unavailable
- Authors
- Li, Junan; Mahajan, Anjali; Tsai, Ming-Daw
- Year
- 2006
- Journal
- Biochemistry
- PMID
- 17176038
- DOI
- 10.1021/bi062188q
Ankyrin repeat, one of the most widely existing protein motifs in nature, consists of 30-34 amino acid residues and exclusively functions to mediate protein-protein interactions, some of which are directly involved in the development of human cancer and other diseases. Each ankyrin repeat exhibits a helix-turn-helix conformation, and strings of such tandem repeats are packed in a nearly linear array to form helix-turn-helix bundles with relatively flexible loops. The global structure of an ankyrin repeat protein is mainly stabilized by intra- and inter-repeat hydrophobic and hydrogen bonding interactions. The repetitive and elongated nature of ankyrin repeat proteins provides the molecular bases of the unique characteristics of ankyrin repeat proteins in protein stability, folding and unfolding, and binding specificity. Recent studies have demonstrated that ankyrin repeat proteins do not recognize specific sequences, and interacting residues are discontinuously dispersed into the whole molecules of both the ankyrin repeat protein and its partner. In addition, the availability of thousands of ankyrin repeat sequences has made it feasible to use rational design to modify the specificity and stability of physiologically important ankyrin repeat proteins and even to generate ankyrin repeat proteins with novel functions through combinatorial chemistry approaches.
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| Multispecies genome-wide analysis defines the MAP3K gene family in Gossypium hirsutum and reveals conserved family expansions. | Bokros N et al. | β | 2019 | β |
| Preliminary results from structural systems biology approach in Tetrahymena thermophila reveal novel perspectives for this toxicological model. | Chasapis CT | β | 2019 | β |
| REC114 Partner ANKRD31 Controls Number, Timing, and Location of Meiotic DNA Breaks. | Boekhout M et al. | β | 2019 | β |
| RNA Expression Profile and Alternative Splicing Signatures of Genistein-Treated Breeder Hens Revealed by Hepatic Transcriptomic Analysis. | Lv Z et al. | β | 2019 | β |
| Role of a 19S Proteasome Subunit- PSMD10<sup>Gankyrin</sup> in Neurogenesis of Human Neural Progenitor Cells. | Sahu I et al. | β | 2019 | β |
| SANS (USH1G) Molecularly Links the Human Usher Syndrome Protein Network to the Intraflagellar Transport Module by Direct Binding to IFT-B Proteins. | Sorusch N et al. | β | 2019 | β |
| Size and structure of the sequence space of repeat proteins. | Marchi J et al. | β | 2019 | β |
| Small Fluorescein Arsenical Hairpin-Based FΓΆrster Resonance Energy Transfer Analysis Reveals Changes in Amino- to Carboxyl-Terminal Interactions upon OAG Activation of Classical Transient Receptor Potential 6. | Fiedler S et al. | β | 2019 | β |
| Spatiotemporal expression profile of embryonic and adult ankyrin repeat and EF-hand domain containing protein 1-encoding genes ankef1a and ankef1b in zebrafish. | Daniel JG et al. | β | 2019 | β |
| The Ankyrin Repeat Domain Controls Presynaptic Localization of Drosophila Ankyrin2 and Is Essential for Synaptic Stability. | Weber T et al. | β | 2019 | β |
| The Cancer Genome Atlas dataset-based analysis of aberrantly expressed genes by GeneAnalytics in thymoma associated myasthenia gravis: focusing on T cells. | Xi J et al. | β | 2019 | β |
| The difference in serum proteomes in schizophrenia and bipolar disorder. | Smirnova L et al. | β | 2019 | β |
| The first draft genomes of the ant Formica exsecta, and its Wolbachia endosymbiont reveal extensive gene transfer from endosymbiont to host. | Dhaygude K et al. | β | 2019 | β |
| The Germline Variants rs61757955 and rs34988193 Are Predictive of Survival in Lower Grade Glioma Patients. | Chatrath A et al. | β | 2019 | β |
| The NONEXPRESSOR OF PATHOGENESIS-RELATED GENES 1 (NPR1) and Related Family: Mechanistic Insights in Plant Disease Resistance. | Backer R et al. | β | 2019 | β |
| Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. | Mohan K et al. | β | 2019 | β |
| Advances in the Application of Designed Ankyrin Repeat Proteins (DARPins) as Research Tools and Protein Therapeutics. | Boersma YL | β | 2018 | β |
| Adventures in Defining Roles of Oxygenases in the Regulation of Protein Biosynthesis. | Walport LJ et al. | β | 2018 | β |
| ANKRD9 is associated with tumor suppression as a substrate receptor subunit of ubiquitin ligase. | Lee Y et al. | β | 2018 | β |
| Ankyrin-Like Protein AnkB Interacts with CatB, Affects Catalase Activity, and Enhances Resistance of Xanthomonas oryzae pv. oryzae and Xanthomonas oryzae pv. oryzicola to Phenazine-1-Carboxylic Acid. | Pan X et al. | β | 2018 | β |
| Ankyrin repeats as a dimerization module. | Kozlov G et al. | β | 2018 | β |
| 'Disc-o-Fever': Getting Down with Giardia's Groovy Microtubule Organelle. | Nosala C et al. | β | 2018 | β |
| Gankyrin: a novel promising therapeutic target for hepatocellular carcinoma. | Zamani P et al. | β | 2018 | β |
| Genome Sequencing and analyses of Two Marine Fungi from the North Sea Unraveled a Plethora of Novel Biosynthetic Gene Clusters. | Kumar A et al. | β | 2018 | β |
| Genome-wide identification and characterization of the SBP-box gene family in Petunia. | Zhou Q et al. | β | 2018 | β |
| <i>ketu</i> mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2. | Jain D et al. | β | 2018 | β |
| Legionella effector AnkX interacts with host nuclear protein PLEKHN1. | Yu X et al. | β | 2018 | β |
| MIB-1 Is Required for Spermatogenesis and Facilitates LIN-12 and GLP-1 Activity in <i>Caenorhabditis elegans</i>. | Ratliff M et al. | β | 2018 | β |
| Nanobodies: Chemical Functionalization Strategies and Intracellular Applications. | Schumacher D et al. | β | 2018 | β |
| New paradigm in ankyrin repeats: Beyond protein-protein interaction module. | Islam Z et al. | β | 2018 | β |
| PRMT1 Deficiency in Mouse Juvenile Heart Induces Dilated Cardiomyopathy and Reveals Cryptic Alternative Splicing Products. | Murata K et al. | β | 2018 | β |
| Structural basis for the recognition of kinesin family member 21A (KIF21A) by the ankyrin domains of KANK1 and KANK2 proteins. | Guo Q et al. | β | 2018 | β |
| Structural insights into the molecular mechanism of mouse TRPA1 activation and inhibition. | Samanta A et al. | β | 2018 | β |
| T-cell transcriptomics from peripheral blood highlights differences between polymyositis and dermatomyositis patients. | Houtman M et al. | β | 2018 | β |
| The role of TRPV4 in fibrosis. | Zhan L et al. | β | 2018 | β |
| The structure of iPLA<sub>2</sub>Ξ² reveals dimeric active sites and suggests mechanisms of regulation and localization. | Malley KR et al. | β | 2018 | β |
| ANK1 and DnaK-TPR, Two Tetratricopeptide Repeat-Containing Proteins Primarily Expressed in <i>Toxoplasma</i> Bradyzoites, Do Not Contribute to Bradyzoite Differentiation. | Yang J et al. | β | 2017 | β |
| ANKRD22 promotes progression of non-small cell lung cancer through transcriptional up-regulation of E2F1. | Yin J et al. | β | 2017 | β |
| Block V RTX Domain of Adenylate Cyclase from Bordetella pertussis: A Conformationally Dynamic Scaffold for Protein Engineering Applications. | Bulutoglu B et al. | β | 2017 | β |
| Deletion of RD<sup>INK4/ARF</sup> enhancer: A novel mutation to "inactivate" the INK4-ARF locus. | Poi MJ et al. | β | 2017 | β |
| Dysbiosis in chronic periodontitis: Key microbial players and interactions with the human host. | Deng ZL et al. | β | 2017 | β |
| Evolutionary diversification of protein-protein interactions by interface add-ons. | Plach MG et al. | β | 2017 | β |
| Genomics Reveals a Unique Clone of <i>Burkholderia cenocepacia</i> Harboring an Actively Excising Novel Genomic Island. | Patil PP et al. | β | 2017 | β |
| Growth on Chitin Impacts the Transcriptome and Metabolite Profiles of Antibiotic-Producing <i>Vibrio coralliilyticus</i> S2052 and <i>Photobacterium galatheae</i> S2753. | Giubergia S et al. | β | 2017 | β |
| <i>ketu</i>mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2 | Jain D et al. | β | 2017 | β |
| <i>Legionella</i> Effector AnkX Disrupts Host Cell Endocytic Recycling in a Phosphocholination-Dependent Manner. | Allgood SC et al. | β | 2017 | β |
| Insights from molecular dynamics simulations for computational protein design. | Childers MC et al. | β | 2017 | β |
| Intensification: A Resource for Amplifying Population-Genetic Signals with Protein Repeats. | Chen J et al. | β | 2017 | β |
| Molecular architecture of an N-formyltransferase from Salmonella enterica O60. | Woodford CR et al. | β | 2017 | β |
| Oncodomains: A protein domain-centric framework for analyzing rare variants in tumor samples. | Peterson TA et al. | β | 2017 | β |
| Protein palmitoylation: Palmitoyltransferases and their specificity. | Tabaczar S et al. | β | 2017 | β |
| QuaDMutEx: quadratic driver mutation explorer. | Bokhari Y et al. | β | 2017 | β |
| Recent advances in the development of novel protein scaffolds based therapeutics. | Azhar A et al. | β | 2017 | β |
| Structural Mimicry by a Bacterial F Box Effector Hijacks the Host Ubiquitin-Proteasome System. | Wong K et al. | β | 2017 | β |
| SVMRFE based approach for prediction of most discriminatory gene target for type II diabetes. | Kumar A et al. | β | 2017 | β |
| Transcriptome Sequencing Reveals Novel Candidate Genes for <i>Cardinium hertigii</i>-Caused Cytoplasmic Incompatibility and Host-Cell Interaction. | Mann E et al. | β | 2017 | β |
| Up-regulation of ANKDR49, a poor prognostic factor, regulates cell proliferation of gliomas. | Hao C et al. | β | 2017 | β |
| Vaccinia Virus Encodes a Novel Inhibitor of Apoptosis That Associates with the Apoptosome. | Ryerson MR et al. | β | 2017 | β |
| An Adaptable Spectrin/Ankyrin-Based Mechanism for Long-Range Organization of Plasma Membranes in Vertebrate Tissues. | Bennett V et al. | β | 2016 | β |
| Analyses of Physcomitrella patens Ankyrin Repeat Proteins by Computational Approach. | Mahmood N et al. | β | 2016 | β |
| Anks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis. | Lee H et al. | β | 2016 | β |
| Bacteriophage WO Can Mediate Horizontal Gene Transfer in Endosymbiotic <i>Wolbachia</i> Genomes. | Wang GH et al. | β | 2016 | β |
| Development and Application of Functionalized Protein Binders in Multicellular Organisms. | Bieli D et al. | β | 2016 | β |
| IBTK Differently Modulates Gene Expression and RNA Splicing in HeLa and K562 Cells. | Fiume G et al. | β | 2016 | β |
| In silico SNP analysis of the breast cancer antigen NY-BR-1. | Kosaloglu Z et al. | β | 2016 | β |
| Novel Insights into the Multiple Sclerosis Risk Gene ANKRD55. | Lopez de Lapuente A et al. | β | 2016 | β |
| N-terminal tetrapeptide T/SPLH motifs contribute to multimodal activation of human TRPA1 channel. | Hynkova A et al. | β | 2016 | β |
| Phytochrome-interacting ankyrin repeat protein 2 modulates phytochrome A-mediated PIF3 phosphorylation in light signal transduction. | Yoo J et al. | β | 2016 | β |
| Positive and strongly relaxed purifying selection drive the evolution of repeats in proteins. | Persi E et al. | β | 2016 | β |
| Retracing the path of planar cell polarity. | Schenkelaars Q et al. | β | 2016 | β |
| Revealing aperiodic aspects of solenoid proteins from sequence information. | Hrabe T et al. | β | 2016 | β |
| Scratching the Surface: Resurfacing Proteins to Endow New Properties and Function. | Chapman AM et al. | β | 2016 | β |
| Structural insights into nonvesicular lipid transport by the oxysterol binding protein homologue family. | Tong J et al. | β | 2016 | β |
| Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification. | Eisemann T et al. | β | 2016 | β |
| The GIY-YIG Type Endonuclease Ankyrin Repeat and LEM Domain-Containing Protein 1 (ANKLE1) Is Dispensable for Mouse Hematopoiesis. | Braun J et al. | β | 2016 | β |
| The Nuclear Protein IΞΊBΞΆ Forms a Transcriptionally Active Complex with Nuclear Factor-ΞΊB (NF-ΞΊB) p50 and the Lcn2 Promoter via the N- and C-terminal Ankyrin Repeat Motifs. | Kohda A et al. | β | 2016 | β |
| Vaccinia virus K1 ankyrin repeat protein inhibits NF-ΞΊB activation by preventing RelA acetylation. | Bravo Cruz AG et al. | β | 2016 | β |
| A FYVE zinc finger domain protein specifically links mRNA transport to endosome trafficking. | Pohlmann T et al. | β | 2015 | β |
| An Ankyrin-G N-terminal Gate and Protein Kinase CK2 Dually Regulate Binding of Voltage-gated Sodium and KCNQ2/3 Potassium Channels. | Xu M et al. | β | 2015 | β |
| ANKHD1 silencing inhibits Stathmin 1 activity, cell proliferation and migration of leukemia cells. | Machado-Neto JA et al. | β | 2015 | β |
| ANKS3 Co-Localises with ANKS6 in Mouse Renal Cilia and Is Associated with Vasopressin Signaling and Apoptosis In Vivo in Mice. | DelestrΓ© L et al. | β | 2015 | β |
| Ankyrin domain of myosin 16 influences motor function and decreases protein phosphatase catalytic activity. | Kengyel A et al. | β | 2015 | β |
| A Regulated, Ubiquitin-Independent Degron in IΞΊBΞ±. | Fortmann KT et al. | β | 2015 | β |
| Artificial affinity proteins as ligands of immunoglobulins. | Mouratou B et al. | β | 2015 | β |
| A transcription blocker isolated from a designed repeat protein combinatorial library by in vivo functional screen. | Tikhonova EB et al. | β | 2015 | β |
| Cancer predisposing BARD1 mutations affect exon skipping and are associated with overexpression of specific BARD1 isoforms. | Ratajska M et al. | β | 2015 | β |
| Clinicopathologic features and prognostic implications of Gankyrin protein expression in non-small cell lung cancer. | Wang WP et al. | β | 2015 | β |
| CLPB mutations cause 3-methylglutaconic aciduria, progressive brain atrophy, intellectual disability, congenital neutropenia, cataracts, movement disorder. | Wortmann SB et al. | β | 2015 | β |
| Designed ankyrin repeat proteins are effective targeting elements for chimeric antigen receptors. | Hammill JA et al. | β | 2015 | β |
| Designed ankyrin repeat proteins (DARPins): binding proteins for research, diagnostics, and therapy. | PlΓΌckthun A | β | 2015 | β |
| Identification of a Novel Sequence Motif Recognized by the Ankyrin Repeat Domain of zDHHC17/13 S-Acyltransferases. | Lemonidis K et al. | β | 2015 | β |
| Leucine-Rich Repeat Kinase 1 Regulates Autophagy through Turning On TBC1D2-Dependent Rab7 Inactivation. | Toyofuku T et al. | β | 2015 | β |
| Mapping the Interaction of B Cell Leukemia 3 (BCL-3) and Nuclear Factor ΞΊB (NF-ΞΊB) p50 Identifies a BCL-3-mimetic Anti-inflammatory Peptide. | Collins PE et al. | β | 2015 | β |
| Mesocorticolimbic dopamine functioning in primary psychopathy:Β A source of within-group heterogeneity. | Yildirim BO et al. | β | 2015 | β |
| MicroRNA-451 plays a role in murine embryo implantation through targeting Ankrd46, as implicated by a microarray-based analysis. | Li Z et al. | β | 2015 | β |
| Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2. | Xiao D et al. | β | 2015 | β |
| Nanobodies and recombinant binders in cell biology. | Helma J et al. | β | 2015 | β |
| Nasal immunization with M cell-targeting ligand-conjugated ApxIIA toxin fragment induces protective immunity against Actinobacillus pleuropneumoniae infection in a murine model. | Park J et al. | β | 2015 | β |
| New role for the ankyrin repeat revealed by a study of the N-formyltransferase from Providencia alcalifaciens. | Woodford CR et al. | β | 2015 | β |
| Novel p16 binding peptide development for p16-overexpressing cancer cell detection using phage display. | Khemthongcharoen N et al. | β | 2015 | β |
| Novel PLA2G6 mutations associated with an exonic deletion due to non-allelic homologous recombination in a patient with infantile neuroaxonal dystrophy. | Yamamoto T et al. | β | 2015 | β |
| Poxviral ankyrin proteins. | Herbert MH et al. | β | 2015 | β |
| Rab40C is a novel Varp-binding protein that promotes proteasomal degradation of Varp in melanocytes. | Yatsu A et al. | β | 2015 | β |
| Sensory TRP channels: the key transducers of nociception and pain. | Mickle AD et al. | β | 2015 | β |
| Synthetic Proteins Potently and Selectively Bind the Oncoprotein Gankyrin, Modulate Its Interaction with S6 ATPase, and Suppress Gankyrin/MDM2-Dependent Ubiquitination of p53. | Chapman AM et al. | β | 2015 | β |
| The Ankyrin Repeat Domain 49 (ANKRD49) Augments Autophagy of Serum-Starved GC-1 Cells through the NF-ΞΊB Pathway. | Wang HL et al. | β | 2015 | β |
| Transcriptome profiling during a natural host-parasite interaction. | McTaggart SJ et al. | β | 2015 | β |
| VdNUC-2, the Key Regulator of Phosphate Responsive Signaling Pathway, Is Required for Verticillium dahliae Infection. | Deng S et al. | β | 2015 | β |
| An ankyrin repeat domain of AKR2 drives chloroplast targeting through coincident binding of two chloroplast lipids. | Kim DH et al. | β | 2014 | β |
| Ankyrin domains across the Tree of Life. | Jernigan KK et al. | β | 2014 | β |
| Ankyrin-repeat proteins from sponge symbionts modulate amoebal phagocytosis. | Nguyen MTHD et al. | β | 2014 | β |
| A novel method for identification and quantification of consistently differentially methylated regions. | Hsiao CL et al. | β | 2014 | β |
| A virulence factor encoded by a polydnavirus confers tolerance to transgenic tobacco plants against lepidopteran larvae, by impairing nutrient absorption. | Di Lelio I et al. | β | 2014 | β |
| Computational design of a leucine-rich repeat protein with a predefined geometry. | RΓ€misch S et al. | β | 2014 | β |
| Crystal structure of an antiviral ankyrin targeting the HIV-1 capsid and molecular modeling of the ankyrin-capsid complex. | Praditwongwan W et al. | β | 2014 | β |
| Dramatic expansion of the black widow toxin arsenal uncovered by multi-tissue transcriptomics and venom proteomics. | Haney RA et al. | β | 2014 | β |
| Ectromelia virus encodes a family of Ankyrin/F-box proteins that regulate NFΞΊB. | Burles K et al. | β | 2014 | β |
| From DARPins to LoopDARPins: novel LoopDARPin design allows the selection of low picomolar binders in a single round of ribosome display. | Schilling J et al. | β | 2014 | β |
| From fluorescence polarization to Quenchbody: Recent progress in fluorescent reagentless biosensors based on antibody and other binding proteins. | Ueda H et al. | β | 2014 | β |
| Human 60-kDa lysophospholipase contains an N-terminal L-asparaginase domain that is allosterically regulated by L-asparagine. | Karamitros CS et al. | β | 2014 | β |
| Identifying tandem Ankyrin repeats in protein structures. | Chakrabarty B et al. | β | 2014 | β |
| Initial characterization of vaccinia virus B4 suggests a role in virus spread. | Burles K et al. | β | 2014 | β |
| Large proportion of genes in one cryptic WO prophage genome are actively and sex-specifically transcribed in a fig wasp species. | Wang GH et al. | β | 2014 | β |
| Prediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of leucine-rich repeat kinase 2 (LRRK2). | Mills RD et al. | β | 2014 | β |
| Recombinant myxoma virus lacking all poxvirus ankyrin-repeat proteins stimulates multiple cellular anti-viral pathways and exhibits a severe decrease in virulence. | Lamb SA et al. | β | 2014 | β |
| Regulation of nuclear translocation of the Myb1 transcription factor by TvCyclophilin 1 in the protozoan parasite Trichomonas vaginalis. | Hsu HM et al. | β | 2014 | β |
| Regulation of plant immunity through ubiquitin-mediated modulation of Ca(2+) -calmodulin-AtSR1/CAMTA3 signaling. | Zhang L et al. | β | 2014 | β |
| Resurfaced shape complementary proteins that selectively bind the oncoprotein gankyrin. | Chapman AM et al. | β | 2014 | β |
| Structural basis of diverse membrane target recognitions by ankyrins. | Wang C et al. | β | 2014 | β |
| Structural insight into the assembly of TRPV channels. | Huynh KW et al. | β | 2014 | β |
| Structure of thermally activated TRP channels. | Cohen MR et al. | β | 2014 | β |
| Tankyrases: structure, function and therapeutic implications in cancer. | Haikarainen T et al. | β | 2014 | β |
| The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity. | Lemonidis K et al. | β | 2014 | β |
| Understanding and identifying amino acid repeats. | Luo H et al. | β | 2014 | β |
| A NOMPC-dependent membrane-microtubule connector is a candidate for the gating spring in fly mechanoreceptors. | Liang X et al. | β | 2013 | β |
| CACTIN is an essential nuclear protein in Arabidopsis and may be associated with the eukaryotic spliceosome. | Baldwin KL et al. | β | 2013 | β |
| Cell- and subunit-specific mechanisms of CNG channel ciliary trafficking and localization in C. elegans. | Wojtyniak M et al. | β | 2013 | β |
| Crystal structure of the yeast ribosomal protein rpS3 in complex with its chaperone Yar1. | Holzer S et al. | β | 2013 | β |
| Cytosolic events involved in chloroplast protein targeting. | Lee DW et al. | β | 2013 | β |
| Evidence that P12, a specific variant of P16(INK4A), plays a suppressive role in human pancreatic carcinogenesis. | Poi MJ et al. | β | 2013 | β |
| Evolutionary, structural and functional interplay of the IΞΊB family members. | Basith S et al. | β | 2013 | β |
| Familial melanoma-associated mutations in p16 uncouple its tumor-suppressor functions. | Jenkins NC et al. | β | 2013 | β |
| Functional environmental screening of a metagenomic library identifies stlA; a unique salt tolerance locus from the human gut microbiome. | Culligan EP et al. | β | 2013 | β |
| Genetic basis for phenotypic differences between different Toxoplasma gondii type I strains. | Yang N et al. | β | 2013 | β |
| Genome-wide identification and expression profiling of ankyrin-repeat gene family in maize. | Jiang H et al. | β | 2013 | β |
| Holocarboxylase synthetase interacts physically with euchromatic histone-lysine N-methyltransferase, linking histone biotinylation with methylation events. | Li Y et al. | β | 2013 | β |
| In silico ionomics segregates parasitic from free-living eukaryotes. | Greganova E et al. | β | 2013 | β |
| Interactions between Arabidopsis acyl-CoA-binding proteins and their protein partners. | Du ZY et al. | β | 2013 | β |
| Mutations in CDKN2C (p18) and CDKN2D (p19) may cause sporadic parathyroid adenoma. | Gluick T et al. | β | 2013 | β |
| New quantitative trait loci for carotid atherosclerosis identified in an intercross derived from apolipoprotein E-deficient mouse strains. | Rowlan JS et al. | β | 2013 | β |
| Proteomic analysis of clathrin interactions in trypanosomes reveals dynamic evolution of endocytosis. | Adung'a VO et al. | β | 2013 | β |
| Single-molecule FRET reveals the native-state dynamics of the IΞΊBΞ± ankyrin repeat domain. | Lamboy JA et al. | β | 2013 | β |
| Structure of the Legionella effector AnkX reveals the mechanism of phosphocholine transfer by the FIC domain. | Campanacci V et al. | β | 2013 | β |
| Superfamily of ankyrin repeat proteins in tomato. | Yuan X et al. | β | 2013 | β |
| TcNPR3 from Theobroma cacao functions as a repressor of the pathogen defense response. | Shi Z et al. | β | 2013 | β |
| The role of gingival melanin pigmentation in inflammation of gingiva, based on genetic analysis. | Eid HA et al. | β | 2013 | β |
| The Shigella OspC3 effector inhibits caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection. | Kobayashi T et al. | β | 2013 | β |
| The study of pH-dependent stability shows that the TPLH-mediated hydrogen-bonding network is important for the conformation and stability of human gankyrin. | Yuan C et al. | β | 2013 | β |
| Transcriptional profiling of Neurospora crassa Ξmak-2 reveals that mitogen-activated protein kinase MAK-2 participates in the phosphate signaling pathway. | Gras DE et al. | β | 2013 | β |
| Ankrd17 positively regulates RIG-I-like receptor (RLR)-mediated immune signaling. | Wang Y et al. | β | 2012 | β |
| ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells. | Liu XF et al. | β | 2012 | β |
| Antiviral activity of recombinant ankyrin targeted to the capsid domain of HIV-1 Gag polyprotein. | Nangola S et al. | β | 2012 | β |
| Bare lymphocyte syndrome: an opportunity to discover our immune system. | Shrestha D et al. | β | 2012 | β |
| Comparative genomics suggests an independent origin of cytoplasmic incompatibility in Cardinium hertigii. | Penz T et al. | β | 2012 | β |
| Designed ankyrin repeat proteins (DARPins) from research to therapy. | Tamaskovic R et al. | β | 2012 | β |
| Genomics and localization of the Arabidopsis DHHC-cysteine-rich domain S-acyltransferase protein family. | Batistic O | β | 2012 | β |
| Identification, characterization, and function analysis of the Cactus gene from Litopenaeus vannamei. | Li C et al. | β | 2012 | β |
| In silico analysis reveals the presence of a large number of Ankyrin repeat containing proteins in Ectocarpus siliculosus. | Mahmood N et al. | β | 2012 | β |
| It takes two to tango: IΞΊBs, the multifunctional partners of NF-ΞΊB. | Hinz M et al. | β | 2012 | β |
| Laboratory metabolic evolution improves acetate tolerance and growth on acetate of ethanologenic Escherichia coli under non-aerated conditions in glucose-mineral medium. | FernΓ‘ndez-Sandoval MT et al. | β | 2012 | β |
| Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism. | Cassago A et al. | β | 2012 | β |
| Next-generation sequencing identifies TGF-Ξ²1-associated gene expression profiles in renal epithelial cells reiterated in human diabetic nephropathy. | Brennan EP et al. | β | 2012 | β |
| NF-ΞΊB: where did it come from and why? | Gilmore TD et al. | β | 2012 | β |
| Putting proteins in their place: palmitoylation in Huntington disease and other neuropsychiatric diseases. | Young FB et al. | β | 2012 | β |
| Regulation of nucleocytoplasmic shuttling of Bruton's tyrosine kinase (Btk) through a novel SH3-dependent interaction with ankyrin repeat domain 54 (ANKRD54). | Gustafsson MO et al. | β | 2012 | β |
| Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock. | Xu C et al. | β | 2012 | β |
| Structures of usher syndrome 1 proteins and their complexes. | Pan L et al. | β | 2012 | β |
| Systematic evaluation of apoptotic pathway gene polymorphisms and lung cancer risk. | Lin J et al. | β | 2012 | β |
| The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane. | Tanno H et al. | β | 2012 | β |
| The expression of one ankyrin pk2 allele of the WO prophage is correlated with the Wolbachia feminizing effect in isopods. | Pichon S et al. | β | 2012 | β |
| TolC-dependent secretion of an ankyrin repeat-containing protein of Rickettsia typhi. | Kaur SJ et al. | β | 2012 | β |
| Tumor suppressor p16INK4a controls oncogenic K-Ras function in human pancreatic cancer cells. | Rabien A et al. | β | 2012 | β |
| Yar1 protects the ribosomal protein Rps3 from aggregation. | Koch B et al. | β | 2012 | β |
| A genome-wide association study of DSM-IV cannabis dependence. | Agrawal A et al. | β | 2011 | β |
| A member of the mitogen-activated protein 3-kinase family is involved in the regulation of plant vacuolar glucose uptake. | Wingenter K et al. | β | 2011 | β |
| An ankyrin repeat protein is involved in anthocyanin biosynthesis in Arabidopsis. | Yoo J et al. | β | 2011 | β |
| An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains. | Licchesi JD et al. | β | 2011 | β |
| Bringing host-cell takeover by pathogenic bacteria to center stage. | Dubreuil R et al. | β | 2011 | β |
| Cytoplasmic oxysterol-binding proteins: sterol sensors or transporters? | Vihervaara T et al. | β | 2011 | β |
| DARPins and other repeat protein scaffolds: advances in engineering and applications. | Boersma YL et al. | β | 2011 | β |
| Decoding bacteriophage P22 assembly: identification of two charged residues in scaffolding protein responsible for coat protein interaction. | Cortines JR et al. | β | 2011 | β |
| Diverse LEA (late embryogenesis abundant) and LEA-like genes and their responses to hypersaline stress in post-diapause embryonic development of Artemia franciscana. | Wu G et al. | β | 2011 | β |
| Functional regulation of transient receptor potential canonical 7 by cGMP-dependent protein kinase IΞ±. | Yuasa K et al. | β | 2011 | β |
| H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases. | Hansen KR et al. | β | 2011 | β |
| Identification of hypoxia-induced genes in human SGBS adipocytes by microarray analysis. | Geiger K et al. | β | 2011 | β |
| Mutations in TRPV4 cause an inherited arthropathy of hands and feet. | LamandΓ© SR et al. | β | 2011 | β |
| Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention. | Dennis EA et al. | β | 2011 | β |
| Phylogenetic analysis of the large family of poxvirus ankyrin-repeat proteins reveals orthologue groups within and across chordopoxvirus genera. | Sonnberg S et al. | β | 2011 | β |
| Quantitative mass spectrometry reveals dynamics of factor-inhibiting hypoxia-inducible factor-catalyzed hydroxylation. | Singleton RS et al. | β | 2011 | β |
| Reagentless fluorescent biosensors from artificial families of antigen binding proteins. | Miranda FF et al. | β | 2011 | β |
| Regulatory mechanisms of tumor suppressor P16(INK4A) and their relevance to cancer. | Li J et al. | β | 2011 | β |
| Rickettsial evolution in the light of comparative genomics. | Merhej V et al. | β | 2011 | β |
| Structural and functional insights into IΞΊB-Ξ±/HIV-1 Tat interaction. | Vitagliano L et al. | β | 2011 | β |
| Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease. | Guettler S et al. | β | 2011 | β |
| Structural biology of TRP channels. | Li M et al. | β | 2011 | β |
| ThANKs for the repeat: Intracellular pathogens exploit a common eukaryotic domain. | Voth DE | β | 2011 | β |
| The yeast kinase Yck2 has a tripartite palmitoylation signal. | Roth AF et al. | β | 2011 | β |
| Versatile TPR domains accommodate different modes of target protein recognition and function. | Allan RK et al. | β | 2011 | β |
| ANK6, a mitochondrial ankyrin repeat protein, is required for male-female gamete recognition in Arabidopsis thaliana. | Yu F et al. | β | 2010 | β |
| ANKRD13C acts as a molecular chaperone for G protein-coupled receptors. | Parent A et al. | β | 2010 | β |
| Contributions of conserved TPLH tetrapeptides to the conformational stability of ankyrin repeat proteins. | Guo Y et al. | β | 2010 | β |
| Effector prediction in host-pathogen interaction based on a Markov model of a ubiquitous EPIYA motif. | Xu S et al. | β | 2010 | β |
| Evolution of alternative splicing in primate brain transcriptomes. | Lin L et al. | β | 2010 | β |
| Functional analysis of the Theobroma cacao NPR1 gene in Arabidopsis. | Shi Z et al. | β | 2010 | β |
| Functional diversity of ankyrin repeats in microbial proteins. | Al-Khodor S et al. | β | 2010 | β |
| Gankyrin Oncoprotein: Structure, Function, and Involvement in Cancer. | Li J et al. | β | 2010 | β |
| Global transcriptomic response of Leptospira interrogans serovar Copenhageni upon exposure to serum. | Patarakul K et al. | β | 2010 | β |
| Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response--a predictive kinetic model. | Schmierer B et al. | β | 2010 | β |
| In silico structural and functional analysis of fragments of the ankyrin repeat protein p18(INK4c). | SklenovsΓ½ P et al. | β | 2010 | β |
| Knowledge-based design of reagentless fluorescent biosensors from a designed ankyrin repeat protein. | Brient-Litzler E et al. | β | 2010 | β |
| Mechanistic insights on spider neurotoxins. | Luch A | β | 2010 | β |
| Medicago truncatula Vapyrin is a novel protein required for arbuscular mycorrhizal symbiosis. | Pumplin N et al. | β | 2010 | β |
| Phage WO of Wolbachia: lambda of the endosymbiont world. | Kent BN et al. | β | 2010 | β |
| Structural basis for capping protein sequestration by myotrophin (V-1). | Zwolak A et al. | β | 2010 | β |
| Structure function studies of vaccinia virus host range protein k1 reveal a novel functional surface for ankyrin repeat proteins. | Li Y et al. | β | 2010 | β |
| The diverse functions of oxysterol-binding proteins. | Raychaudhuri S et al. | β | 2010 | β |
| The genome of the amoeba symbiont "Candidatus Amoebophilus asiaticus" reveals common mechanisms for host cell interaction among amoeba-associated bacteria. | Schmitz-Esser S et al. | β | 2010 | β |
| The muscle ankyrin repeat proteins are hypoxia-sensitive: in vivo mRNA expression in the hypoxia-tolerant blind subterranean mole rat, Spalax ehrenbergi. | Band M et al. | β | 2010 | β |
| The spectrin-ankyrin-4.1-adducin membrane skeleton: adapting eukaryotic cells to the demands of animal life. | Baines AJ | β | 2010 | β |
| Two distinct mechanisms for actin capping protein regulation--steric and allosteric inhibition. | Takeda S et al. | β | 2010 | β |
| A four-gene signature from NCI-60 cell line for survival prediction in non-small cell lung cancer. | Hsu YC et al. | β | 2009 | β |
| Analysis of the genome of the Escherichia coli O157:H7 2006 spinach-associated outbreak isolate indicates candidate genes that may enhance virulence. | Kulasekara BR et al. | β | 2009 | β |
| An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia. | Benita Y et al. | β | 2009 | β |
| A novel ankyrin-repeat protein interacts with the regulatory proteins of inner arm dynein f (I1) of Chlamydomonas reinhardtii. | Ikeda K et al. | β | 2009 | β |
| Asparaginyl beta-hydroxylation of proteins containing ankyrin repeat domains influences their stability and function. | Hardy AP et al. | β | 2009 | β |
| Differences in hydroxylation and binding of Notch and HIF-1alpha demonstrate substrate selectivity for factor inhibiting HIF-1 (FIH-1). | Wilkins SE et al. | β | 2009 | β |
| Disruption of chromosome 11 in canine fibrosarcomas highlights an unusual variability of CDKN2B in dogs. | Aguirre-HernΓ‘ndez J et al. | β | 2009 | β |
| Evolution of a subtilisin-like protease gene family in the grass endophytic fungus EpichloΓ« festucae. | Bryant MK et al. | β | 2009 | β |
| FIH-dependent asparaginyl hydroxylation of ankyrin repeat domain-containing proteins. | Cockman ME et al. | β | 2009 | β |
| Functional dynamics of the folded ankyrin repeats of I kappa B alpha revealed by nuclear magnetic resonance. | Cervantes CF et al. | β | 2009 | β |
| Genetic enhancement of thalamocortical network activity by elevating alpha 1g-mediated low-voltage-activated calcium current induces pure absence epilepsy. | Ernst WL et al. | β | 2009 | β |
| Genome comparison of a nonpathogenic myxoma virus field strain with its ancestor, the virulent Lausanne strain. | Morales M et al. | β | 2009 | β |
| Homology, paralogy and function of DGF-1, a highly dispersed Trypanosoma cruzi specific gene family and its implications for information entropy of its encoded proteins. | Kawashita SY et al. | β | 2009 | β |
| Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress. | Sun TP et al. | β | 2009 | β |
| Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17. | Deng M et al. | β | 2009 | β |
| Inhibitor of nuclear factor-kappaB alpha derepresses hypoxia-inducible factor-1 during moderate hypoxia by sequestering factor inhibiting hypoxia-inducible factor from hypoxia-inducible factor 1alpha. | Shin DH et al. | β | 2009 | β |
| Interplay between poxviruses and the cellular ubiquitin/ubiquitin-like pathways. | Zhang L et al. | β | 2009 | β |
| Kank proteins: structure, functions and diseases. | Kakinuma N et al. | β | 2009 | β |
| Mapping of protein phosphatase-6 association with its SAPS domain regulatory subunit using a model of helical repeats. | Guergnon J et al. | β | 2009 | β |
| Molecular diversity of spider venom. | Vassilevski AA et al. | β | 2009 | β |
| Molecular mimicry: an important virulence strategy employed by Legionella pneumophila to subvert host functions. | Nora T et al. | β | 2009 | β |
| Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes. | Gazave E et al. | β | 2009 | β |
| Penelope's web: using alpha-latrotoxin to untangle the mysteries of exocytosis. | Silva JP et al. | β | 2009 | β |
| Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins. | Cockman ME et al. | β | 2009 | β |
| Selection and characterization of DARPins specific for the neurotensin receptor 1. | Milovnik P et al. | β | 2009 | β |
| Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase. | Yang Y et al. | β | 2009 | β |
| The alternative splice variant of DAPK-1, s-DAPK-1, induces proteasome-independent DAPK-1 destabilization. | Lin Y et al. | β | 2009 | β |
| The ankyrin repeat domain of Huntingtin interacting protein 14 contains a surface aromatic cage, a potential site for methyl-lysine binding. | Gao T et al. | β | 2009 | β |
| The BTB/POZ domain of the Arabidopsis disease resistance protein NPR1 interacts with the repression domain of TGA2 to negate its function. | Boyle P et al. | β | 2009 | β |
| The planar cell polarity (PCP) protein Diversin translocates to the nucleus to interact with the transcription factor AF9. | Haribaskar R et al. | β | 2009 | β |
| An alternative transcript from the death-associated protein kinase 1 locus encoding a small protein selectively mediates membrane blebbing. | Lin Y et al. | β | 2008 | β |
| A primer on ankyrin repeat function in TRP channels and beyond. | Gaudet R | β | 2008 | β |
| Co-operative versus independent transport of different cargoes by Kinesin-1. | Hammond JW et al. | β | 2008 | β |
| Crystal structure of the BARD1 ankyrin repeat domain and its functional consequences. | Fox D et al. | β | 2008 | β |
| De novo identification of highly diverged protein repeats by probabilistic consistency. | Biegert A et al. | β | 2008 | β |
| Identification of novel bradyzoite-specific Toxoplasma gondii genes with domains for protein-protein interactions by suppression subtractive hybridization. | Friesen J et al. | β | 2008 | β |
| Intragenic tandem repeat variation between Legionella pneumophila strains. | Coil DA et al. | β | 2008 | β |
| Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk. | Spatuzza C et al. | β | 2008 | β |
| Pre-folding IkappaBalpha alters control of NF-kappaB signaling. | Truhlar SM et al. | β | 2008 | β |
| Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation. | Minami M et al. | β | 2008 | β |
| The diversity of insect-bacteria interactions and its applications for disease control. | Shanchez-Contreras M et al. | β | 2008 | β |
| The IkappaBalpha/NF-kappaB complex has two hot spots, one at either end of the interface. | Bergqvist S et al. | β | 2008 | β |
| The Whole-genome sequencing of the obligate intracellular bacterium Orientia tsutsugamushi revealed massive gene amplification during reductive genome evolution. | Nakayama K et al. | β | 2008 | β |
| Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and P16. | Mahajan A et al. | β | 2007 | β |
| Gene expression profiling of MPP+-treated MN9D cells: a mechanism of toxicity study. | Wang J et al. | β | 2007 | β |
| Human p16gamma, a novel transcriptional variant of p16(INK4A), coexpresses with p16(INK4A) in cancer cells and inhibits cell-cycle progression. | Lin YC et al. | β | 2007 | β |
| Wolbachia-host interactions: connecting phenotype to genotype. | Iturbe-Ormaetxe I et al. | β | 2007 | β |