Adults living in the Croatian villages of Komiza and Vis (island of Vis) and from Korcula (island of Korcula) were recruited within a larger epidemiological study of genetically isolated populations (Rudan et al. 1999). The CROATIA-Vis study comprised 536 women and 388 men aged 18–93 years (mean=56.4±15.5). The CROATIA-Korcula study comprised 573 women and 325 men aged 18–98 years (mean=56.3±13.9).