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Chunk #5 — Materials and Methods — Sample — Lothian Birth Cohorts 1921 (LBC1921) and 1936 (LBC1936)

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Genome-wide association uncovers shared genetic effects among personality traits and mood states.
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These relatively healthy older individuals, living in the Lothian region of Scotland, were born in 1921 or 1936 and assessed on psychological and medical traits from the age of 79 (LBC1921) or 70 (LBC1936) years (Luciano et al. 2010). In the LBC1921, genotype and phenotype data were available for 426 (personality) and 517 (depression, anxiety) participants (58% female); mean age of ~81 years (range=80–82) when personality was assessed and 79±0.6 years (range=77–81) when depression and anxiety symptoms were measured. In the LBC1936, 880 (personality) and 1 003 (depression, anxiety) individuals (50% female) had genotype and phenotype data; mean age of 69.5±0.8 years (range=67–71).