The UKB is a prospective study of approximately 500,000 participants 40–69 years of age at recruitment. Participants were recruited in the UK between 2006 and 2010 and are continuously followed47. The average age at recruitment for sequenced individuals was 56.5 years and 54% of the sequenced cohort comprises those of female sex. Participant data include health records that are periodically updated by the UKB, self-reported survey information, linkage to death and cancer registries, collection of urine and blood biomarkers, imaging data, accelerometer data and various other phenotypic end points1. All study participants provided informed consent.
