In light of the fact that Type I error was not adequately controlled, whether within a study or across studies within the same research group, it cannot be surprising that several of the findings listed in Table 6 have not replicated. Roussos and colleagues divided the LOGOS sample into a discovery and replication sample and conducted a GWAS of PPI and startle reactivity (Roussos et al., 2015). Although they did obtain unreplicated novel genome-wide significant hits for two, they did not obtain significant associations between any candidate genes previously found to be associated with PPI, including those listed in Table 6 which they themselves had previously obtained.
