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Chunk #123 — 9.0 Selective Review of Electrophysiological Biomarkers as Candidate Endophenotypes — 9.2 Selective review of molecular genetic studies of endophenotypes

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Endophenotype best practices.
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The GWAS by Roussos and colleagues is listed in Table 7, along with GWAS or studies similarly using a genome-wide scan, representing seven electrophysiological endophenotypes in all. To avoid redundancy, we did not add to this table the GWAS results from the 17 endophenotypes examined in our special issue of Psychophysiology that are included in Table 2, none of which are covered in Table 7, or the results we obtained for event-related theta power described in section 5.2, a measure that is included in Table 7. Examples of the challenges that we faced and discussed in section 5.0 are also apparent in several of these studies. Zlojutro and colleagues with the Consortium on the Genetics of Alcoholism (COGA) conducted a GWAS of event-related EEG theta activity in a discovery sample of 1,064 subjects, from which 42 SNPs were prioritized for replication in a second, family-based sample of 1,095 subjects from 242 families with many alcohol-dependent individuals (Zlojutro et al., 2011). None of the variants were genome-wide significant. Table 7 lists a second GWAS of event-related theta activity conducted by COGA,