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Chunk #42 — Discussion — Choice of Reference and EEG Asymmetry

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Resting frontal EEG asymmetry as an endophenotype for depression risk: sex-specific patterns of frontal brain asymmetry.
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reference montage, and Henriques and Davidson (1990) found that previously depressed but euthymic individuals showed relatively less left frontal activity than never depressed controls using the LM reference montage. One key difference between these studies and the present study might be that the present study obtained a sample that spanned a wide range of depressive severity, such that the participants with no history of major depression in the present study did not have an absence of depressive symptoms. The lifetime MDD- participants in the present study had a mean BDI-II score of 6.2, whereas the never-depressed controls in the Henriques and Davidson (1990) study had comparatively little symptomatology (mean BDI of 1.4). Because lifetime MDD- participants in the current study had at least some level of symptomatology, the present study may have been at a disadvantage to find differences between lifetime MDD+ and lifetime MDD- if frontal EEG asymmetry under these montages tracks symptom severity to some extent.