transpopulation meta-analysis showed that statistical significance increased by over an order of magnitude (to 1.02×10−13) with improved evidence for localization of the lead SNP at CHRH1 (Figure 2c). A similar phenomenon has been observed in narrowing associated regions for schizophrenia when meta-analyzing EUR and Asian GWAS results (48). Gene-based analyses and the replication in the UK Biobank provided additional evidence supporting CRHR1 as a risk locus.
