On chromosome 8, rs7821592, the implicated locus is XPO7. Although this locus was identified as being of interest in a prior sparse “pooled GWAS” study of AD (49), and was identified in a study of AD comorbid with bipolar disorder (50), it has never previously been identified for these traits at anything approaching GWS. Finally, in EUR, rs1577857 (LOC105378478) on chromosome 10 has apparently not been reported previously. Although this variant is located in a non-coding RNA gene not previously associated with any human phenotype, the association in the MVP cohort was also replicated in PGC and UK Biobank cohorts. Additionally, the regulatory functional significance of this locus is supported by the fact that the variant is in a DNase I hypersensitivity site detected in twelve different cell types(51).
