The samples used for the development and validation of the Internalizing Scale were drawn from the Collaborative Study on the Genetics of Alcoholism, a prospective multi-site genetic study of families at high risk for alcohol use disorders (AUD).37,38 Institutional Review Boards at all six sites reviewed and approved the study. Parents provided consent for all offspring below 18; individuals 13 and older also provided consent, and children aged 12 provided assent.
