Comparisons of resting state PAC comodulograms from those with severe AUD and unaffected controls revealed patterns of increased PAC strength in the AUD group across different phase-amplitude frequency pair domains (Figure 1A) within which an initial set of significant clusters were found (Figure 1B). In AUD men, significant clusters of stronger PAC were found in the delta-gamma, theta-gamma, and alpha-gamma frequency pair domains (Figure 1B, men) that aligned with PAC “hotspots” in effect size comodulograms. Similar PAC hotspots can be found in gamma amplitude frequencies in women (Figure 1A, women) though to less a degree in the delta-gamma and theta-gamma domains and were small compared to the alpha-gamma cluster.
