Assessment of the initial set of significant clusters using phase-amplitude frequency pair domains framed around each of the clusters in the set revealed significant AUD-associated PAC differences in both men and women at four PAC domains (Figure 2). Each of the four PAC clusters identified in the initial comodulogram analysis were tested in men and women (Table 2). Even though men and women were analyzed separately, there was considerable overlap in the PAC domains where significant differences were found.
