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Chunk #19 — RESULTS

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Alcohol use disorder is associated with increases in frontocentral phase-amplitude coupling strength during resting state.
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Men with severe AUD exhibited significantly elevated PAC strength compared to unaffected men at all cluster-bounding PAC domains. PAC strength for the AUD group was greater in the theta-gamma (PAC domain A, p=0.006), alpha-gamma (PAC domain B, p=0.014), theta-alpha (PAC domain C, p=0.032), and alpha-beta (PAC domain D, p=0.038) domains. Women with severe AUD exhibited, like the men with AUD, had significantly elevated PAC strength in alpha-gamma (PAC domain B, p=0.019), theta-alpha (PAC domain C, p=0.002), and alpha-beta (PAC domain D, p=0.044) domains, though unlike men, women with AUD exhibited significant decreases in PAC strength in the theta-gamma domain (PAC domain B, p=0.036).