The present study examined whether severe AUD diagnosis was associated with any changes in PAC strength in the midline prefrontal region as measured from channel FZ during EEG resting state eyes closed condition when compared to unaffected controls. Findings revealed significant AUD-associated changes to PAC strength in the alpha-gamma, theta-gamma, alpha-beta, and theta-beta frequency pair domains. Both men and women with severe AUD were found to have significantly increased alpha-gamma PAC, though the elevated PAC strength in AUD men was shifted to slower alpha rhythms than in AUD women. Increased alpha-beta PAC was also seen in severe AUD regardless of sex. In AUD women, the range of amplitude frequency in the alpha-beta domain was in low beta (14-17 Hz) while in AUD men it was in mid-beta band (18-22 Hz). Both men and women with severe AUD exhibited increased theta-alpha PAC than unaffected members of both sexes though with sex-specific differences in how wide the amplitude frequency range where significant PAC was seen. Theta phase modulation of alpha band amplitudes in AUD women encompassed the entire alpha frequency band (8-12
