PAC than unaffected members of both sexes though with sex-specific differences in how wide the amplitude frequency range where significant PAC was seen. Theta phase modulation of alpha band amplitudes in AUD women encompassed the entire alpha frequency band (8-12 Hz). In AUD men, the range of amplitude frequency included high alpha and low beta (11-14 Hz). Difference comodulograms for both men and women revealed increased PAC strength in overlapping theta-gamma domains (Figure 1A), though subsequent cluster analysis showed significant increases only in AUD men (Table 2). The only significant decrease in PAC was found among AUD women in a slow theta-gamma subdomain.
