In this study, we performed admixture mapping of DSM-IV alcohol dependence diagnosis, DSM-IV alcohol dependence criterion count, and two SRE scores in four cohorts of AA. To our knowledge, this is the first genome-wide admixture mapping analysis of any of those four alcohol-related phenotypes in AA. One region on chromosome 4 was genome-wide significant (i.e., P-value <7.25E-05) for SRE-5.