scores (Table 3) and the effective allele frequencies were higher in Africans than in non-Finnish Europeans for all of these variants, except rs79462764. This was consistent with the results of admixture mapping. All variants in Table 3 individually had conditional P-values <0.01, indicating that they did not individually explain the admixture mapping association signal. When conditioned collectively on rs76004436, rs3966916, rs11931595, and rs10018808 (four independent variants with the lowest P-values), the conditional analysis had P-value >0.01, demonstrating that these four variants (or variants in LD with them) were driving the admixture mapping association signal. Supplemental Figure 2 shows the regional association plots that those four variants were index variants. Variants that were in LD with those index variants were all located in a small region between 24.37 Mbp and 24.52 Mbp. Supplemental Figure 3 depicts the proportion of African ancestry on chromosome 4 for all cohorts. As can be seen, the proportion of African ancestry differed dramatically at different locations for all four cohorts.
