Of the primary analytic sample (i.e., EA participants with GWAS data, n = 7591), 66.3% had ever used cannabis in their lifetime, and 28.2% met criteria for lifetime DSM-5 CUD [mild (2–3 criteria; 8.8%), moderate (4–5 criteria; 6.9%), severe (6+ criteria; 12.4%)]. Among those who had ever used cannabis in their lifetime, 42.6% met criteria for lifetime DSM-5 CUD [mild (13.6%), moderate (10.6%), severe (18.4%)]. Among cannabis users, mean number of CUD symptoms was 2.39 (Range: 0–11, SD: 3.14). A greater number of symptoms were observed among men and younger individuals.
