Among EAs, main effects of the PRS were observed for cannabis ever use and for DSM-5 CUDsx (Table 2; Fig. 1): PRS with p < 0.05, p < 0.10, p < 0.20, p < 0.30, p < 0.40, and p < 0.50 thresholds were nominally associated with ever cannabis use (p ranging from 0.009 to 0.001) and PRS with p < 0.001, p < 0.01, p < 0.05, p < 0.10, p < 0.20, p < 0.30, p < 0.40, and p < 0.50 thresholds were associated with DSM-5 CUDsx (p ranging from 0.036 to 0.001), but only nominally in ever users (p ranging from 0.043 to 0.005). Associations of PRS (p < 0.05 threshold) with ever cannabis use and PRS (p < 0.10 threshold) with DSM-5 CUDsx withstood a Bonferonni correction for multiple testing. Above and beyond the aggregate effects of the sex, birth cohort, genotype array, and ancestral PCs, the PRS with p < 0.05 accounted for 0.2% of the variance in ever cannabis use (area under the curve (AUC): 0.53 (0.52, 0.54)) and 0.2% of the variance
