Chunk #36 — Results — KLF12: Regulation of acute functional tolerance to ethanol in C. elegans and gene expression correlation with locomotor activity in mice
There is significant prior evidence for a role of KLF12 in ethanol response behaviors across species. In BXD mice, Klf12 is regulated by acute ethanol in PFC, NAc and VTA, and is a hub in a network of ethanol responsive genes (Wolen et al., 2012). In humans, KLF12 acts in combination with the co-repressor CTBP1 (Schuierer et al., 2001), and in C. elegans, the ctbp-1 gene is required for the development of AFT (Bettinger et al., 2012). The closest C. elegans ortholog to human KLF12 is klf-3, and this evidence collectively suggests KLF-3 is likely to act together with CTBP-1 to regulate AFT in worms.
