genome-wide significant loci compared with the European-only ancestry studies analysis. Using conditional-and-joint GCTA-COJO12 analysis with threshold p ≤ 5 × 10−8 within 10 Mb windows for the combined meta-analysis, we identified 697 significant independent single-nucleotide polymorphisms (SNPs) in 635 genomic regions. About half (293/635; 46%) of the discovered loci were novel MD associations (Figure 2; see key resources table) of which 100 were identified due to the inclusion of cohorts with ancestrally diverse samples. The European-only analysis identified 622 SNPs in 570 regions with a net change in the full meta-analysis of 65 (142 regions gained, 77 regions became non-significant).
