ASPD diagnosis is based on a relatively broad range of antisocial behavioral characteristics. To elucidate the origin of the strong association signal arising from rs4714329 to ASPD, we analyzed each 22 characterizing items of the SCID II questionnaire individually (Supplementary Information; page 1, Supplementary Tables 7 and 8 and Supplementary Figure 5). The odds ratios for all of the 22 questions were quite similar, ranging between 1.4 and 1.7. The most significant association was achieved for item (20), ‘Reckless disregard for safety of self or others' with the OR of 1.66 (1.41–1.94) and a P-value of 6.0 × 10−10 (heterogeneity index I2=0.44 (scale 0–1), indicating more variation than expected by chance) in the meta-analysis (N cases=477, N controls=9616). The most significant association with the heterogeneity index value of zero was observed for item (16), ‘Failure to conform to social norms with respect to lawful behaviors, as indicated by repeatedly performing acts that are ground for arrest' (OR=1.60 (1.37–1.87), P=1.7 × 10−9, N cases=529, N controls=9616). The most significant items typically included >400 individuals each, whereas some of the items, such
