The present study was carried out to further elucidate the relationship between ethanol and fat and determine whether TG and OX mediate this connection. Specifically, this investigation sought to determine whether: 1) ethanol intake increases preference for dietary fat, just as fat increases ethanol intake; 2) ethanol and fat synergize in their stimulatory effect on TG levels; 3) lowering TG levels with gemfibrozil reduces ethanol intake; and 4) lowering TG suppresses the orexigenic peptide, OX, which stimulates ethanol as well as fat intake.