the effect of ethanol on locomotion compared with the sodh-1(ok2799) mutation alone (Figure 3a). These results indicate that the difference in ethanol accumulation seen with sodh-1(ok2799) mutant animals is sufficient to alter the behavior of the animals when they are exposed to ethanol. Surprisingly, the measured internal ethanol concentration for animals with a loss of both sodh-1 and H24K24.3 was not different from wild-type animals (Figure 2c) and yet these animals show a significant increase in ethanol sensitivity compared with wild-type animals (Figure 3a).
