Chunk #114 — 9.0 Selective Review of Electrophysiological Biomarkers as Candidate Endophenotypes — 9.1 A review of how well candidate endophenotypes satisfy threshold criteria
The sheer number of entries in Table 5 attests to the level of interest in endophenotypes and biomarkers. What is perhaps less apparent is that interest is increasing, judging from the number of papers published in recent years. The majority of work has focused on addressing the threshold criteria, which is clearly a desirable first step to establishing a given measure as a putative endophenotype. The viability of some measures as endophenotypes is stronger than for others in that it is supported by meta-analysis or at least the results of a narrative review, whereas one or two empirical reports is all that we could find for others. This may be because interest in a particular measure as an endophenotype is recent, as is the case with feedback-related negativity, reward positivity, measures of connectivity or phase synchrony, broadband noise, and other measures that are more recently available to endophenotype researchers. In other cases, such as the oddball N2 amplitude, interest seems to have faded. There have been a number of twin studies, which establish broadly that heritable individual differences are evident
