Chunk #115 — 9.0 Selective Review of Electrophysiological Biomarkers as Candidate Endophenotypes — 9.1 A review of how well candidate endophenotypes satisfy threshold criteria
measures that are more recently available to endophenotype researchers. In other cases, such as the oddball N2 amplitude, interest seems to have faded. There have been a number of twin studies, which establish broadly that heritable individual differences are evident for the majority of putative endophenotypes. Many studies have also been conducted of healthy first-degree relatives of probands with a clinical disorder, who presumably share the genetic liability for the disorder despite not having manifested it. Somewhat fewer studies have been conducted with children or youth at high risk for a disorder by virtue of a positive family history.
