According to the specific structure of complement molecules, complement mutants and complement peptides can also be used to regulate complement activity [58,59]. Moreover, the crosstalk between the complement, coagulation, and fibrinolysis systems also plays an important role in complement regulation. As an example, thrombomodulin participates in complement regulation through two mechanisms. Thrombomodulin can enhance factor I-mediated inactivation of C3b on the cell surface. Moreover, thrombomodulin also accelerates the inactivation of anaphylatoxins C3a and C5a by regulating the activation of procarboxypeptidase B [60,61]. These strategies may be also applicable to the treatment of ALD.
