Recent advances in complement research have shown that the complement system acts an important regulator for each stage of ALD. The precise regulatory mechanisms of the complement system in the occurrence and development of ALD need to be further explored. A better understanding of the mechanisms by which the complement system affects ALD may help us identify novel therapeutic targets and provide a potential therapeutic approach to inhibit or reverse the progression of ALD. Based on the advances of the present research, targeted complement inhibitors and antisense inhibition of Gly-tRF may provide a therapeutic strategy for treating human ALD.
