Other measures have been proposed to predict alcoholism risk. Possibly, the acute locomotor stimulation seen after low doses of alcohol, particularly in mice, may serve as a model of some of the activating effects in humans. However, correlations between acute stimulation in standard inbred mouse strains (Crabbe et al. 2003;Cunningham 1995) or in the BXD RI strains (Phillips et al. 1996) and drinking are not robust. Neither are the correlations substantial with withdrawal severity in either data set (Metten, Crabbe 2005;Crabbe 1998). Furthermore, WSP and WSR mice do not differ in acute stimulation after alcohol (Crabbe et al. 1988), nor do HAP and LAP mice (Grahame et al. 2000).
