Unlike mice, heterogeneous stock rats generally do not show a robust stimulant response to alcohol, but a survey of the data from selectively bred high versus low alcohol-consuming rat lines revealed a consistent positive association between alcohol-induced motor stimulation and a propensity for high alcohol intake. In an early study, it was reported that adult P rats displayed alcohol-induced stimulation, whereas NP rats did not (Waller et al. 1986). A recent comprehensive study in both male and female adolescent P versus NP, HAD-1 versus LAD-1 and HAD-2 versus LAD-2 (Rodd et al. 2004) reported that all of the high alcohol-consuming lines displayed alcohol-induced stimulation at lower doses (0.25 to 0.75 g/kg), whereas the low alcohol-consuming lines did not. In addition, using an operant protocol Krimmer and Schechter (Krimmer, Schechter 1991) reported alcohol-induced motor stimulation in HAD-1, but not LAD-1, rats. The University of Chile lines also show the above differences, such that UChB rats displayed alcohol-induced motor stimulation at lower doses (0.25 and 0.50 g/kg), whereas UChA rats were unaffected (Quintanilla 1999). Similarly, sP rats display low dose alcohol-induced locomotor
