The University of Chile lines also show the above differences, such that UChB rats displayed alcohol-induced motor stimulation at lower doses (0.25 and 0.50 g/kg), whereas UChA rats were unaffected (Quintanilla 1999). Similarly, sP rats display low dose alcohol-induced locomotor activation, whereas sNP rats do not (Agabio et al. 2001). While direct comparisons with low alcohol-consuming rats cannot be made with alcohol self-administration procedures, it is noteworthy that AA (Paivarinta, Korpi 1993), P (Bell et al. 2002;Melendez et al. 2002), and sP (Colombo et al. 1998) rats display alcohol-induced locomotor activation during self-administration. Finally, HAP and LAP mice do not differ in sensitivity to alcohol-induced locomotor activation, but HAP mice display dose-dependent sensitization whereas LAP mice do not (Grahame et al. 2000).
