Although previous studies have reported differences in EEG coherence among individuals diagnosed with AD and related neuropsychiatric conditions, no comprehensive genomic studies have been published prior to this first GWAS of EEG connectivity. We report a genome-wide significant signal in a 5.4 kb intergenic region on chromosome 18q23. The most significant SNP, rs12954372, located in a brain-expressed lincRNA AC107892 was positively associated with not only low theta (3-5 Hz) EEG coherence, but also with alcohol use behaviors (e.g., maxdrinks), and corpus callosum volume in the COGA sample, and with alcohol intake frequency and corpus callosum volume in an independent sample.
