An association of rs12954372 with posterior corpus callosum volume measured via MRI was found in the UK Biobank sample (N = 3,722, B: 0.03; p: 0.042); the same association was found in a subset of young adult offspring from COGA families in COGA’s prospective study on whom MRI data was available (N = 60, B: 0.34; p: 0.038, Figure 2). In the MRI subsample of COGA’s prospective study, posterior interhemispheric low theta coherence was associated with increased maxdrinks (N:50, B:0.51, p<0.0001), but not DSM-IV AD (N= 49, B: 0.12, p: 0.415) or posterior corpus callosum volume (N: 49, B: 0.18, p: 0.230).
